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AMPK A2/B1/G1 Recombinant Human Protein

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AMP-activated protein kinase (AMPK) is a heterotrimeric complex that acts as a sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulating metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. An impairment in fuel metabolism that occurs in obesity is a factor leading to Type 2 diabetes. The insulin resistance associated with type 2 diabetes is most profound at the level of skeletal muscle, the primary site of glucose and fatty acid utilization. Activation of AMPK is of interest for the treatment of type 2 diabetes.
For Research Use Only. Not for use in diagnostic procedures.


Species: Human
Gene Aliases: AMPK A2/B1/G1
Kinase Group: Ser⁄Thr Kinases: CAMK Group
Product Size: 10 µg
Protein Family: Kinases & Inhibitors
Protein Subtype: Serine⁄Threonine Kinases
Accession Number: NP_0062243.2 I NP_006244.2 I NP_002724.1
Molecular Weight: 91.4/ 57.8/ 41.7 kDa
Research Category: Signal Transduction
System Compatibility: LanthaScreen® Substrate, Omnia® Bulk Substrate, Z'-LYTE™, LanthaScreen® Antibody
Validated Application: Kinase Assay
Protein Tag or Fusion: GST Tag, His Tag
Tag Position: GST (N-Terminal)⁄GST (N-Terminal)⁄His (N-Terminal)
Expression: Baculovirus
Kinase Family: CAMKL Kinase Family
Protein Form: Full Length, Recombinant
Shipping Condition: Dry Ice

Contents & storage

Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.02% Triton X-100, 0.5 mM EDTA, 2 mM DTT, 50% Glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.


Manuals & protocols