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AMPK A2/B1/G1 Recombinant Human Protein

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Description

AMP-activated protein kinase (AMPK) is a heterotrimeric complex that acts as a sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulating metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. An impairment in fuel metabolism that occurs in obesity is a factor leading to Type 2 diabetes. The insulin resistance associated with type 2 diabetes is most profound at the level of skeletal muscle, the primary site of glucose and fatty acid utilization. Activation of AMPK is of interest for the treatment of type 2 diabetes.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_0062243.2 I NP_006244.2 I NP_002724.1
Expression: Baculovirus
Gene Aliases: AMPK A2/B1/G1
Kinase Family: CAMKL Kinase Family
Kinase Group: Ser⁄Thr Kinases: CAMK Group
Molecular Weight: 91.4/ 57.8/ 41.7 kDa
Product Size: 10 µg
Protein Family: Kinases & Inhibitors
Protein Form: Full Length,Recombinant
Protein Subtype: Serine⁄Threonine Kinases
Protein Tag or Fusion: GST Tag,His Tag
Research Category: Signal Transduction
Shipping Condition: Dry Ice
Species: Human
System Compatibility: LanthaScreen® Antibody,LanthaScreen® Substrate,Omnia® Bulk Substrate,Z'-LYTE™
Tag Position: GST (N-Terminal)⁄GST (N-Terminal)⁄His (N-Terminal)
Validated Application: Kinase Assay

Contents & storage

Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.02% Triton X-100, 0.5 mM EDTA, 2 mM DTT, 50% Glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.