For order quantities > 1, multiple lots may be used to fulfill the order. If you require a single lot, please email discoverysciences@lifetech.com to ensure your needs are accommodated

88 more kinases now available to order! See the complete list.

EGFR (ErbB1) [T790M] [L858R] Recombinant Human Protein

Catalog number:  PV4879

Related applications:

Pharma & Biopharma

| Protein Assays and Analysis

Back to top

Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_005219.2; T790M L858R
Assay Entry: Biochemical binding/kinetic
Kinase Group: Tyrosine Kinases
Shipping Condition: Dry Ice
System Compatibility: Z'-LYTE™
Target Entry: EGFR T790M L858R
Target Gene: Epidermal growth factor receptor
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Recombinant, Cytoplasmic
Protein Subtype: Receptor Tyrosine Kinases
Research Category: Oncology, Signal Transduction
Species: Human
Validated Application: Kinase Assay
Gene ID (Entrez): 1956
Molecular Weight: 90.6 kDa
Gene Alias: EGFR (ErbB1) T790M L858R
KinaseFamily: EGF Receptor (ErbB) Kinase Family
Protein Length: aa 668-1210; T790M, L858R
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.