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EGFR (ErbB1) [T790M] [L858R] Recombinant Human Protein

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The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
For Research Use Only. Not for use in diagnostic procedures.


Gene ID: 1956
Species: Human
Target Gene: Epidermal growth factor receptor
Gene Aliases: EGFR (ErbB1) T790M L858R
Kinase Group: Tyrosine Kinases
Product Size: 10 µg
Protein Family: Kinases & Inhibitors
Protein Subtype: Receptor Tyrosine Kinases
Accession Number: NP_005219.2; T790M L858R
Molecular Weight: 90.6 kDa
Research Category: Signal Transduction, Oncology
System Compatibility: Z'-LYTE™
Protein Tag or Fusion: GST Tag
Validated Application: Kinase Assay
Protein Length or Portion (a.a.): aa 668-1210; T790M, L858R
Expression: Baculovirus
Kinase Family: EGF Receptor (ErbB) Kinase Family
Protein Form: Recombinant, Cytoplasmic
Shipping Condition: Dry Ice

Contents & storage

Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.


Manuals & protocols