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LRRK2 [G2019S] Recombinant Human Protein

Catalog number:  PV4881

Related applications:

Protein Assays and Analysis

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Description

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease. The G2019S mutation of LRRK2 is associated with an increase in catalytic activity.

Related Links:
LRRK2 tools for advancing Parkinson's disease research
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LanthaScreen® Eu Kinase Binding Assay
LanthaScreen® Activity Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_940980.2, G2019S
Assay Entry: Biochemical ADP accumulation, Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group: Ser⁄Thr Kinases: TKL Group
Shipping Condition: Dry Ice
System Compatibility: LanthaScreen® Antibody, LanthaScreen® Substrate, Adapta™
Target Entry: LRRK2 G2019S
Target Gene: Leucine-rich repeat kinase 2
Expression System: Baculovirus
Protein Family: Kinases & Inhibitors
Protein Form: Recombinant, Catalytic
Protein Subtype: Serine⁄Threonine Kinases
Research Category: Signal Transduction, Neurobiology
Species: Human
Validated Application: Kinase Assay
Gene ID (Entrez): 120892
Molecular Weight: 204.9 kDa
Quantity: 10μg
Gene Alias: LRRK2 G2019S
KinaseFamily: LRRK Kinase Family
Protein Length: aa 970-2527; G2019S
Protein Tag: GST Tag

Contents & storage

Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.