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Invitrogen
CD10 Monoclonal Antibody (MEM-78), Qdot™ 705
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FIGURE: 1 / 1
CD10 Antibody (Q22136) in Flow
Histogram overlay of human leukocytes labeled with CD10 Mouse Anti-Human (clone MEM-78) Qdot® 705 Conjugate. The black line represents cells from the granulocyte gate and the grey line represents cells from the lymphocyte gate. Sample was acquired and analyzed using 405 nm excitation and a 695/40 band pass emission filter using the Attune (R) Acoustic Cytometer Blue/Violet option.
Product Details
Q22136
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MEM-78
Immunogen
Human CD10.
Conjugate
Excitation/Emission Max
300/702 nm
View spectra
Form
Liquid
Purification
purified
Storage buffer
0.05M borate, pH 8.3, with 1M betaine
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CD10, also known as the Common Acute Lymphocytic Leukemia Antigen (CALLA) and neutral endopeptidase (NEP), is a Zn2+-dependent metallo-peptidase with neutral metalloendopeptidase activity. It is a 100 kDa type II transmembrane glycoprotein encoded by a gene that exists in a single copy of greater than 45 kb. The 5' untranslated region of the CD10 gene is alternatively spliced, resulting in four separate mRNA transcripts, although the coding region remains unaffected by alternative splicing. CD10 is involved in the regulation of chemotactic and inflammatory processes involving neutrophils and plays a role in stromal cell-dependent B lymphopoiesis. It is expressed on immature B cells in adult bone marrow, mature B cells in germinal centers, and cells from patients with chronic myelocytic leukemia (CML). Additionally, CD10 is present on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas. Beyond the hematopoietic compartment, CD10 is highly expressed on the brush border of enterocytes and renal tubules and glomeruli, as well as on breast myoepithelial cells, bile canaliculi, and fibroblasts. CD10 cleaves peptides at the amino side of hydrophobic residues, inactivating several biologically active peptides, including endothelin, glucagon, gastrin, neurotensin, bradykinin, enkephalins, substance P, oxytocin, and others. Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie Tooth Disease, highlighting its significance in both normal physiological processes and disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Atriopeptidase; CALLA; CD10; common acute lymphoblastic leukemia antigen precursor; Common acute lymphocytic leukemia antigen; Enkephalinase; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); NEP; NEP-390; NEP-411; Neprilysin; neprilysin-390; neprilysin-411; Neutral endopeptidase 24.11; SFE; Skin fibroblast elastase; unnamed protein product
Gene Aliases: CALLA; CD10; CMT2T; EPN; MME; NEP; SCA43; SFE
UniProt ID: (Human) P08473
Entrez Gene ID: (Human) 4311
phosphatidylserine binding
endopeptidase activity
metallocarboxypeptidase activity
metalloendopeptidase activity
protein binding
peptidase activity
metallopeptidase activity
exopeptidase activity
zinc ion binding
hydrolase activity
peptide binding
protein homodimerization activity
metal ion binding
oligopeptidase activity
cardiolipin binding
kidney development
placenta development
angiotensin maturation
proteolysis
peptide metabolic process
learning or memory
substance P catabolic process
bradykinin catabolic process
protein processing
sensory perception of pain
protein catabolic process
lung development
hormone catabolic process
response to estrogen
creatinine metabolic process
beta-amyloid metabolic process
positive regulation of neurogenesis
neuropeptide processing
cellular response to cytokine stimulus
cellular response to UV-A
cellular response to UV-B
replicative senescence
beta-amyloid clearance
amyloid-beta clearance by cellular catabolic process
positive regulation of long-term synaptic potentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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