Cleavage of von Willebrand Factor Requires the Spacer Domain of the Metalloprotease ADAMTS13.
AuthorsZheng X, Nishio K, Majerus EM, Sadler JE,
JournalJ Biol Chem
PubMed ID12791682
ADAMTS13 consists of a reprolysin-type metalloprotease domain followed by a disintegrin domain, a thrombospondin type 1 motif (TSP1), Cys-rich and spacer domains, seven more TSP1 motifs, and two CUB domains. ADAMTS13 limits platelet accumulation in microvascular thrombi by cleaving the Tyr1605-Met1606 bond in von Willebrand factor, and ADAMTS13 deficiency causes ... More