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Invitrogen
Human LAR4B (aa 645-728) Control Fragment Recombinant Protein
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Product Details
RP-104757
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
LRKPSYAEICQRTSKEPPSSPLQPQKEQKPNTVGCGKEEKKLAEPAERYREPPALKSTPGAPRDQRRPAGGRPSPSAMGKRLSR
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (78%), Rat (78%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-65339. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The LAR4B gene, more accurately referred to as LARP4B (La Ribonucleoprotein Domain Family Member 4B), is associated with RNA-binding proteins that are crucial for various aspects of RNA metabolism, including RNA stabilization, translation, and cellular stress responses. LARP4B belongs to the La-related protein family, which plays significant roles in maintaining RNA stability and enhancing translation efficiency of certain mRNAs. It has been identified as a target in cancer research due to its involvement in tumor biology, particularly regulating tumor suppressive pathways and interacting with microRNA networks. Studies have shown that LARP4B expression is downregulated in prostate cancer tissues, indicating its potential role as a tumor suppressor. Moreover, it is linked with liver cancer and survival rates, reflecting its importance in cellular growth and proliferation. The regulation of LARP4B and its interactions with other cellular components underline its potential therapeutic implications for cancer treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KIAA0217; La ribonucleoprotein domain family member 4B; La ribonucleoprotein domain family member 5; La ribonucleoprotein domain family, member 5; La-related protein 4B; La-related protein 5
Gene Aliases: KIAA0217; LARP4B; LARP5
UniProt ID: (Human) Q92615
Entrez Gene ID: (Human) 23185
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