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Invitrogen
Human SLC26A3 (aa 617-733) Control Fragment Recombinant Protein
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Product Details
RP-89305
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
DQPINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (87%), Rat (87%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57508. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
SLC26A3 is a chloride/bicarbonate exchanger that is involved in absorption inside the colon. SLC26A3 helps mediate electrolyte and fluid absorption. The protein encoded by the SLC26A3 gene is a transmembrane glycoprotein that functions as a sulfate transporter, and it is localized to the mucosa. The chloride ions transported by SLC26A3 cross the cell membrane in exchange for biocarbonate ions. SLC26A3 is localized in the mucosa of the lower intestinal tract, specifically the apical membrane of the columnar epithelium and in some goblet cells. Diseases associated with SLC26A3 protein dysfunction include congenital chloride diarrhea and congenital secretory chloride diarrhea 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chloride anion exchanger; Down-regulated in adenoma; down-regulated in adenoma protein; Protein DRA; solute carrier family 26 (anion exchanger), member 3; Solute carrier family 26 member 3; solute carrier family 26, member 3
Gene Aliases: CLD; DRA; SLC26A3
UniProt ID: (Human) P40879
Entrez Gene ID: (Human) 1811
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