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Invitrogen
Human STOML1 (aa 101-207) Control Fragment Recombinant Protein
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Product Details
RP-89968
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
GPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRA
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (95%), Rat (95%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-59953. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Stomatin-like protein 1 (STOML1) is encoded by the STOML1 gene located on chromosome 17 in humans. It is part of a family of five mammalian genes that encode peripheral membrane proteins involved in modulating ion channel functions. STOML1 is known to interact specifically with members of the acid-sensing ion channel (ASIC) family, influencing their proton sensitivity. These interactions help regulate ion transport and signaling pathways, which are critical for cellular homeostasis. In addition, STOML1 has been studied in the context of oral squamous cell carcinoma (OSCC), where it is often overexpressed along with STOML2, potentially affecting cancer progression. Structurally, STOML1 contains a stomatin domain which is crucial for its role in membrane association and ion channel modulation. Its expression in olfactory sensory neurons (OSNs) is comparatively lower than other family members, but it still contributes to the localization and functional integrity of related proteins in these cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EPB72-like 1; EPB72-like protein 1; protein unc-24 homolog; stomatin (EBP72)-like 1; stomatin (EPB72)-like 1; stomatin-related protein; STOML1; STORP; unnamed protein product
Gene Aliases: hUNC-24; SLP-1; STORP
UniProt ID: (Human) Q9UBI4
Entrez Gene ID: (Human) 9399
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