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Invitrogen
Human PGPEP1 (aa 113-186) Control Fragment Recombinant Protein
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Product Details
RP-95838
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
PESIDSIIDMDAVCKRVTTLGLDVSVTISQDAGRYLCDFTYYTSLYQSHGRSAFVHVPPLGKPYNADQLGRALR
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (97%), Rat (97%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57245. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Pyroglutamyl-peptidase I (PGPEP1) is a gene located on chromosome 19q13.33, encoding an enzyme involved in the removal of pyroglutamyl residues from the N-terminus of peptides and proteins. This enzymatic activity is fundamental in protein processing and metabolism, ensuring proper protein maturation and degradation. PGPEP1 is expressed in multiple tissues, including the liver and kidney, and plays a role in the regulation of biological processes by modulating the activity and stability of pyroglutamyl-containing bioactive peptides. The enzyme's function is crucial for maintaining cellular homeostasis and can influence physiological pathways such as hormone regulation and immune responses. Dysregulation or mutations in PGPEP1 may impact peptide function and have potential implications for various diseases, although the specific clinical significance is still being researched. Insights into PGPEP1's function are contributing to the understanding of protease-related disorders and therapeutic strategies targeting peptide metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-oxoprolyl-peptidase; PAP-I; pGlu-peptidase I; PGP-I; Pyroglutamyl aminopeptidase I; Pyroglutamyl-peptidase 1; Pyroglutamyl-peptidase I; Pyrrolidone-carboxylate peptidase; unnamed protein product
Gene Aliases: PAP-I; Pcp; PGI; PGP; PGP-I; PGPEP1; PGPI
UniProt ID: (Human) Q9NXJ5
Entrez Gene ID: (Human) 54858
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