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Invitrogen
Human CARD8 (aa 425-513) Control Fragment Recombinant Protein
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Product Details
RP-98957
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
TLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLA
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (27%), Rat (27%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-59852. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pesudo-ICE. Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappa-B activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptotic protein NDPP1; CARD 8; CARD inhibitor of NF-kappaB-activating ligands; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; CARDINAL; CARD family adaptor protein; Caspase recruitment domain-containing protein 8; DKFZp779L0366; KI; TUCAN; Tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine; unnamed protein product
Gene Aliases: CARD8; CARDINAL; DACAR; DAKAR; KIAA0955; NDPP; NDPP1; TUCAN
UniProt ID: (Human) Q9Y2G2
Entrez Gene ID: (Human) 22900
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