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OriGene
MAP2K2 Monoclonal Antibody (OTI5B4), TrueMAB™
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Product Details
TA505762S
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5B4
Immunogen
Full length human recombinant protein of human MAP2K2 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
30 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MAP2K2 (MEK2) is a dual specificity serine/threonine kinase that is known to play a critical role in mitogen growth factor signal transduction. Mitogen activated protein kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; ERK kinase 2; FLJ26075; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP2K1; MAPK; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MEK 1; MEK 2; MEK-1; MEK-2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK1; OTTHUMP00000165827; PRKMK1; protein kinase, mitogen activated, kinase 2, p45; unnamed protein product
Gene Aliases: AA589381; CFC4; MAP2K2; MAPKK2; MEK2; MK2; MKK2; PRKMK2
UniProt ID: (Dog) Q1HG70, (Human) P36507, (Mouse) Q63932
Entrez Gene ID: (Dog) 611939, (Human) 5605, (Mouse) 26396
protein serine/threonine kinase activity
protein tyrosine kinase activity
ATP binding
metal ion binding
nucleotide binding
protein kinase activity
MAP kinase kinase activity
protein serine/threonine/tyrosine kinase activity
MAP-kinase scaffold activity
protein binding
kinase activity
transferase activity
PDZ domain binding
protein serine/threonine kinase activator activity
binding, bridging
scaffold protein binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
protein complex scaffold
non-receptor serine/threonine protein kinase
MAPK cascade
peptidyl-tyrosine phosphorylation
heart development
positive regulation of gene expression
Schwann cell development
thyroid gland development
regulation of stress-activated MAPK cascade
peptidyl-serine autophosphorylation
ERBB2-ERBB3 signaling pathway
myelination
positive regulation of transcription, DNA-templated
insulin-like growth factor receptor signaling pathway
thymus development
regulation of axon regeneration
positive regulation of axonogenesis
face development
lung morphogenesis
trachea formation
epithelial cell proliferation involved in lung morphogenesis
ERK1 and ERK2 cascade
positive regulation of protein serine/threonine kinase activity
regulation of Golgi inheritance
positive regulation of cell motility
regulation of early endosome to late endosome transport
activation of MAPK activity
regulation of protein phosphorylation
protein phosphorylation
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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