Search
OriGene
IL34 Monoclonal Antibody (OTI5E1), TrueMAB™
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 9
IL34 Antibody (TA811737) in IHC (P)
Immunohistochemical staining of paraffin-embedded human appendix tissue within the normal limits using anti-IL34 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA811737)(1:1000).
Product Details
TA811737
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI5E1
Immunogen
Human recombinant protein fragment corresponding to amino acids 77-242 of human IL34 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: IL-34; ILN; Interleukin; Interleukin-34; Interleukin34; unnamed protein product
Gene Aliases: C16orf77; IL-34; IL34
UniProt ID: (Human) Q6ZMJ4
Entrez Gene ID: (Human) 146433
positive regulation of protein phosphorylation
immune system process
inflammatory response
positive regulation of cell proliferation
positive regulation of macromolecule metabolic process
positive regulation of gene expression
positive regulation of cell development
positive regulation of macrophage chemotaxis
positive regulation of MAPK cascade
innate immune response
positive regulation of macrophage differentiation
positive regulation of monocyte differentiation
positive regulation of oligodendrocyte differentiation
positive regulation of multicellular organismal process
interleukin-34-mediated signaling pathway
microglial cell proliferation
positive regulation of macrophage proliferation
regulation of multicellular organismal development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support