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OriGene
DDX39B Monoclonal Antibody (OTI2G7), TrueMAB™
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Product Details
TA812666S
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2G7
Immunogen
Human recombinant protein fragment corresponding to amino acids 319-428 of human DDX39B produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
30 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and also plays an important role in mRNA export from the nucleus to the cytoplasm. A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; DEAD box protein UAP56; DEAD-box helicase 39B; HLA-B associated transcript 1; HLA-B-associated transcript 1 protein; HLA-B-associated transcript 1A; nuclear RNA helicase (DEAD family); nuclear RNA helicase Bat1; spliceosome RNA helicase BAT1; Spliceosome RNA helicase DDX39B; unnamed protein product
Gene Aliases: 0610030D10Rik; AI428441; Bat-1; BAT1; Bat1a; D17H6S81E; D17H6S81E-1; D6S81E; D6S81Eh; DDX39B; UAP56
UniProt ID: (Human) Q13838, (Dog) Q5WR10, (Mouse) Q9Z1N5
Entrez Gene ID: (Human) 7919, (Dog) 474839, (Mouse) 53817
nucleotide binding
nucleic acid binding
RNA binding
RNA helicase activity
mRNA binding
helicase activity
protein binding
ATP binding
RNA-dependent ATPase activity
hydrolase activity
ATPase activity
U6 snRNA binding
U4 snRNA binding
identical protein binding
ATP-dependent protein binding
ATP-dependent RNA helicase activity
poly(A) RNA binding
spliceosomal complex assembly
mRNA splicing, via spliceosome
mRNA processing
RNA export from nucleus
mRNA export from nucleus
RNA splicing
mRNA transport
transport
cellular response to DNA damage stimulus
regulation of gene expression
RNA secondary structure unwinding
positive regulation of DNA-templated transcription, elongation
viral mRNA export from host cell nucleus
negative regulation of DNA damage checkpoint
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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