Functional assessment of peptide-modified PLGA nanoparticles against oral biofilms in a murine model of periodontitis.
AuthorsMahmoud MY, Steinbach-Rankins JM, Demuth DR
JournalJ Control Release
PubMed ID30690103
'The interaction of the periodontal pathogen Porphyromonas gingivalis (Pg) with commensal streptococci promotes Pg colonization of the oral cavity. Previously, we demonstrated that a peptide (BAR) derived from Streptococcus gordonii (Sg) potently inhibited adherence of Pg to streptococci and reduced Pg virulence in a mouse model of periodontitis. Thus, BAR ... More
Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy.
AuthorsWang W, Fan J, Zhu G, Wang J, Qian Y, Li H, Ju J, Shan L
JournalInt J Nanomedicine
PubMed ID32425524
Targeted prodrug has various applications as drug formulation for tumor therapy. Therefore, amphoteric small-molecule prodrug combined with nanoscale characteristics for the self-assembly of the nano-drug delivery system (DDS) is a highly interesting research topic. ... More