How straightforward is integration of the Vanquish Neo UHPLC System with our current mass spectrometers?
The Vanquish Neo UHPLC System is built for seamless LCMS integration with Thermo Scientific mass spectrometers with multiple ion source options and instrument control available using Thermo Scientific Chromeleon CDS or SII for Thermo Scientific Xcalibur Software.
We work with precious samples. How do Vanquish (U)HPLC systems minimize sample waste?
Vial-bottom detection supports precise injections from limited sample volumes while the split-loop autosampler limits sample waste during injections.
How does the Vanquish Neo UHPLC System ensure reproducible retention times across such a wide flow rate range?
ProFlow XR active flow control is available from 1 nL/min to 100 µL/min and provides accurate and precise gradient delivery for stable retention time across long and ultrashort runs.
Can one Vanquish Neo UHPLC System cover nano, capillary, and micro flows on the same system?
Yes. It’s designed for low-flow LCMS from 1 nL/min up to 100 µL/min and column inner diameters of 1 mm and below, so it can support applications from proteomics to small molecules without switching platforms.
What detectors can we use with a Vanquish Core HPLC System? Can we use universal detection?
The platform supports multiple detectors (including UV, fluorescence, refractive index, mass spectrometry) and pairs seamlessly with Thermo Scientific Vanquish Charged Aerosol Detectors for near-universal, structure-independent response.
We have legacy HPLC methods. What tools are available to simplify transferring our methods to Vanquish HPLC systems?
Thermo Scientific Vanquish HPLC systems include tools to replicate method behavior, such as tunable gradient delay volume and multiple column heating modes that match existing conditions. They are expressly designed to simplify method transfer from other instruments.
What are the main differences between the iCAP PRO, iCAP PRO X, iCAP PRO XP, and iCAP PRO XPS models?
The main differences among the Thermo Scientific iCAP PRO models are based on their specific features and intended applications:
- iCAP PRO: For routine laboratory analysis with fast start-up, easy-to-use software, and robust performance. It simplifies analysis in laboratories performing standardized analysis for a low number of samples.
- iCAP PRO X: For high-matrix trace elemental analysis with sensitive multi-element detection, ideal for challenging samples. It helps laboratories with moderate throughput and established methods to improve performance and reliability.
- iCAP PRO XP: Flexibility for method optimization and achieves advanced performance using an enhanced ultraviolet (eUV) analysis mode, which measures the UV region of the spectrum with greater sensitivity. Fast data acquisition times allow for high throughput labs to stay competitive.
- iCAP PRO XPS: Exceptional throughput and versatility, meeting specific regulatory requirements with high-speed analysis and excellent stability. With short integration times and high flexibility, this system is appropriate for testing labs that require the high throughput and performance.