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Citations & References (4)
Invitrogen™
Leadmium™ Green AM dye
Leadmium™ Green AM dye
| Catalog Number | Quantity |
|---|---|
| A10024 | 5 x 50 μg |
Catalog number A10024
Price (USD)
266.00
Each
Quantity:
5 x 50 μg
Price (USD)
266.00
Each
The proprietary Leadmium™ Green AM dye from Molecular Probes™ provides researchers with a unique tool to specifically measure intracellular lead and cadmium levels with high sensitivity. While standards assays exist for measuring lead and cadmium in solution, the unique Leadmium™ Green AM indicator was specifically designed to detect these toxic environmental contaminants inside living cells.
- Highly specific indicator for intracellular measurements of lead and cadmium
- Flexible format allows use on multiple formats - flow cytometry, fluorescence microscopy imaging and plate readers
- Bright fluorescence and high discrimination from calcium allows detection of nanomolar levels of lead and micromolar levels of cadmium
- Convenient excitation with 488 nm laser line
- The Leadmium™ Green AM dye is readily loaded and is retained very well following esterase cleavage of the acetoxymethyl group
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Detection MethodFluorescence
Dye TypeLeadmium Green
Emission Wavelength520 nm
Excitation Wavelength490 nm
Quantity5 x 50 μg
Shipping ConditionRoom Temperature
For Use With (Application)Ion Indicator
For Use With (Equipment)Fluorescence Microscope, Flow Cytometer
Product LineLeadmium
Product TypeDye
Unit SizeEach
Contents & Storage
Store in freezer -5°C to -30°C and protect from light.
Citations & References (4)
Citations & References
Abstract
A new ABC half-transporter in Leishmania major is involved in resistance to antimony.
Journal:
PubMed ID:23716044
The characterization of ABCI4, a new intracellular ATP-binding cassette (ABC) half-transporter in Leishmania major, is described. We show that ABCI4 is involved in heavy metal export, thereby conferring resistance to Pentostam, to Sb(III), and to As(III) and Cd(II). Parasites overexpressing ABCI4 showed a lower mitochondrial toxic effect of antimony by
Increased nuclear thioredoxin-1 potentiates cadmium-induced cytotoxicity.
Journal:Toxicol Sci
PubMed ID:22961094
Cadmium (Cd) is a widely dispersed environmental agent that causes oxidative toxicity through mechanisms that are sensitive to thioredoxin-1 (Trx1). Trx1 is a cytoplasmic protein that translocates to nuclei during oxidative stress. Recent research shows that interaction of Trx1 with actin plays a critical role in cell survival and that
Cellular sequestration of cadmium in the hyperaccumulator plant species Sedum alfredii.
Journal:Plant Physiol
PubMed ID:22025609
Spatial imaging of cadmium (Cd) in the hyperaccumulator Sedum alfredii was investigated in vivo by laser ablation inductively coupled plasma mass spectrometry and x-ray microfluorescence imaging. Preferential Cd accumulation in the pith and cortex was observed in stems of the Cd hyperaccumulating ecotype (HE), whereas Cd was restricted to the
Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function.
Journal:PLoS Biol
PubMed ID:17298174
Identification of common mechanistic principles that shed light on the action of the many chemically diverse toxicants to which we are exposed is of central importance in understanding how toxicants disrupt normal cellular function and in developing more effective means of protecting against such effects. Of particular importance is identifying