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Abnova
FOXP2 Monoclonal Antibody (1F8)
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Product Details
H00093986-M02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1F8
Immunogen
FOXP2 (NP_055306, 616 a.a. approximately 715 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: LAESSLPLLS NPGLINNASS GLLQAVHEDL NGSLDHIDSN GNSSPGCSPQ PHIHSIHVKE EPVIAEDEDC PMSLVTTANH SPELEDDREI EEEPLSEDLE
Target Information
FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; alternatively spliced; 3' end may have intronic sequence; CAG repeat protein 44; DKFZp686H1726; Forkhead box protein P2; forkhead/winged-helix transcription factor; FOXP2; FOXP2-S; alternatively spliced; OTTHUMP00000196932; trinucleotide repeat containing 10; Trinucleotide repeat-containing gene 10 protein; truncated splice variant; unnamed protein product
Gene Aliases: CAGH44; FOXP2; SPCH1; TNRC10
UniProt ID: (Human) O15409
Entrez Gene ID: (Human) 93986
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
positive regulation of mesenchymal cell proliferation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
skeletal muscle tissue development
post-embryonic development
gene expression
cerebellum development
cerebellar Purkinje cell differentiation
caudate nucleus development
putamen development
cerebral cortex development
lung development
vocal learning
camera-type eye development
negative regulation of transcription, DNA-templated
lung alveolus development
animal organ development
smooth muscle tissue development
positive regulation of epithelial cell proliferation
righting reflex
positive regulation of epithelial cell proliferation involved in lung morphogenesis
epithelial cell proliferation involved in lung morphogenesis
vocalization behavior
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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