Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • Antibodies
    • Cell Culture Media
    • Chemicals
    • Chromatography Columns and Cartridges
    • Lab Equipment
    • Lab Plasticware and Supplies
    • Microplates
    • Oligos, Primers, Probes and Genes
    • TaqMan Real-Time PCR Assays
    • Greener Products
    • See all product categories
  • Applications
    • Bioprocessing
    • Cell Culture and Transfection
    • Cell and Gene Therapy
    • Chromatography
    • Molecular Testing
    • Digital Solutions
    • DNA and RNA Extraction and Analysis
    • Spectroscopy, Elemental and Isotope Analysis
    • See all applications and techniques
  • Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Custom Services
    • Financial and Leasing Services
    • Instrument Services
    • Lab Informatics
    • OEM and Commercial Supply
    • Training Services
    • Unity Lab Services
    • See all services
  • Help and Support
    • How to Order
    • Instrument Support
    • Learning Centers
    • Register for an Account
    • Technical Support Centers
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Who We Serve
    • Biotech
    • Biopharma
    • CDMO
    • Lab Diagnostics
    • Industrial and Applied Sciences
  • Promotions
  • Contact Us
  • Quick Order
  • Order Status and Tracking
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search

Search All
Search button
          • Order Status
          • Quick Order
          • Promos
          • Sign in
            Sign in
            Don't have an account ? Create Account
            • Account
            • Check Order Status
            • Aspire Member Program
            • Connect: Lab, Data, Apps
            • Custom Products & Projects
            • Services Central
          • Primary Antibodies ›
          • TGF beta-1 Antibodies

          Invitrogen

          TGF beta-1 Polyclonal Antibody

          2 References
          View all (76) TGF beta-1 antibodies

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

          {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Datasheet
          Certificates
          Protocols
          Questions & Answers
          Datasheet
          Certificates
          Protocols
          Questions & Answers

          Cite TGF beta-1 Polyclonal Antibody

          Additional Information:
          {{banner.description}}
          {{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
          TGF beta-1 Polyclonal Antibody

          Product Details

          PA1-9574

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:2,000-1:5,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          -
          View 1 publication 1 publication

          ELISA (ELISA)

          1:2,000-1:5,000
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human, Mouse, Pig, Rat

          Published species

          Rat

          Host/Isotype

          Chicken / IgY

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Peptide based on mouse and human TGF beta-1 protein.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          PBS

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2201915

          Product Specific Information

          PA1-9574 detects TGFb1 in human, mouse and rat samples.

          PA1-9574 has been successfully used in Western blot, Immunohistochemistry, Immunocytochemistry, and ELISA procedures. By Western blot, PA1-9574 detects a 25 kDa protein representing TGFb1.

          PA1-9574 immunogen is a peptide based on mouse and human TGFb1 protein (RKPKVEQLSNMIVRS).

          Store 4c for 1 week and -20c for long term storage.

          Target Information

          TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: cytokine; latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; TGF beta-1; TGF beta-1 protein; tgf beta1; TGF β; TGF β 1; TGF β1; TGF-B1; TGF-beta 1; TGF-beta 1 protein; TGF-beta-1; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; Transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta1; transforming growth factor β1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; unnamed protein product

          View more View less

          Gene Aliases: CED; DPD1; IBDIMDE; LAP; TGF-BETA-1; TGF-beta1; TGFB; Tgfb-1; TGFB1; TGFbeta; TGFbeta1

          View more View less

          UniProt ID: (Human) P01137, (Pig) P07200, (Rat) P17246, (Mouse) P04202

          View more View less

          Entrez Gene ID: (Human) 7040, (Pig) 397078, (Rat) 59086, (Mouse) 21803

          View more View less

          Function(s)
          type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity enzyme binding type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding deubiquitinase activator activity identical protein binding protein serine/threonine kinase activator activity macromolecular complex binding antigen binding glycoprotein binding protein homodimerization activity protein heterodimerization activity protein N-terminus binding growth factor
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter cell morphogenesis vasculogenesis ureteric bud development response to hypoxia morphogenesis of a branching structure cell activation epithelial to mesenchymal transition neural tube closure regulation of sodium ion transport sprouting angiogenesis chondrocyte differentiation columnar/cuboidal epithelial cell maturation hematopoietic progenitor cell differentiation connective tissue replacement involved in inflammatory response wound healing adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains tolerance induction to self antigen negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target heart valve morphogenesis aortic valve morphogenesis protein export from nucleus ATP biosynthetic process phosphate-containing compound metabolic process cellular calcium ion homeostasis apoptotic process inflammatory response transforming growth factor beta receptor signaling pathway Notch signaling pathway negative regulation of neuroblast proliferation salivary gland morphogenesis endoderm development heart development female pregnancy cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation germ cell migration response to xenobiotic stimulus response to wounding response to glucose gene expression regulation of gene expression positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression negative regulation of extracellular matrix disassembly positive regulation of epithelial to mesenchymal transition macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of macrophage cytokine production oligodendrocyte development positive regulation of microglia differentiation regulation of striated muscle tissue development neural tube development hyaluronan catabolic process T cell differentiation negative regulation of ossification negative regulation of cell growth osteoclast differentiation regulation of cell migration positive regulation of cell migration mammary gland development organ regeneration membrane protein intracellular domain proteolysis positive regulation of protein complex assembly positive regulation of exit from mitosis response to estradiol response to progesterone regulation of interleukin-23 production negative regulation of interleukin-17 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production receptor catabolic process positive regulation of superoxide anion generation mononuclear cell proliferation regulation of actin cytoskeleton organization positive regulation of collagen biosynthetic process response to vitamin D response to laminar fluid shear stress response to immobilization stress myofibroblast differentiation T cell proliferation T cell activation regulation of cell proliferation negative regulation of T cell proliferation regulation of protein import into nucleus positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth positive regulation of odontogenesis myelination T cell homeostasis positive regulation of apoptotic process positive regulation of vascular permeability positive regulation of I-kappaB kinase/NF-kappaB signaling surfactant homeostasis proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration regulatory T cell differentiation cell-cell junction organization response to ethanol regulation of regulatory T cell differentiation positive regulation of regulatory T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of myoblast differentiation positive regulation of epidermal growth factor receptor signaling pathway negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter muscle cell cellular homeostasis positive regulation of fibroblast proliferation lung alveolus development positive regulation of isotype switching to IgA isotypes lymph node development digestive tract development negative regulation of skeletal muscle tissue development positive regulation of smooth muscle cell proliferation inner ear development epithelial cell proliferation positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of protein secretion positive regulation of inflammatory response negative regulation of phagocytosis defense response to fungus negative regulation of T cell activation positive regulation of chemotaxis positive regulation of cellular component organization positive regulation of smooth muscle cell differentiation positive regulation of multicellular organismal process positive regulation of protein metabolic process negative regulation of release of sequestered calcium ion into cytosol neuron apoptotic process regulation of cell cycle positive regulation of cell division positive regulation of protein kinase B signaling ventricular cardiac muscle tissue morphogenesis phospholipid homeostasis canonical Wnt signaling pathway regulation of blood vessel remodeling face morphogenesis frontal suture morphogenesis positive regulation of SMAD protein import into nucleus bronchiole development mammary gland branching involved in thelarche branch elongation involved in mammary gland duct branching regulation of branching involved in mammary gland duct morphogenesis regulation of cartilage development retina vasculature development in camera-type eye connective tissue development Langerhans cell differentiation negative regulation of biomineral tissue development regulation of enamel mineralization lens fiber cell differentiation positive regulation of ERK1 and ERK2 cascade response to cholesterol cellular response to mechanical stimulus cellular response to glucose stimulus cellular response to growth factor stimulus cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia cellular response to ionizing radiation cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus positive regulation of mononuclear cell migration odontoblast differentiation stem cell proliferation extracellular matrix assembly positive regulation of branching involved in ureteric bud morphogenesis positive regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway liver regeneration cellular response to virus transforming growth factor beta receptor superfamily signaling pathway negative regulation of hyaluronan biosynthetic process positive regulation of protein localization to nucleus positive regulation of extracellular matrix assembly response to salt positive regulation of mesenchymal stem cell proliferation regulation of miRNA transcription negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of protein localization to plasma membrane positive regulation of vasculature development positive regulation of STAT cascade regulation of epithelial to mesenchymal transition involved in endocardial cushion formation cellular response to acetaldehyde cellular response to insulin-like growth factor stimulus embryonic liver development negative regulation of cell-cell adhesion mediated by cadherin positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of endothelial cell apoptotic process positive regulation of primary miRNA processing positive regulation of stem cell proliferation positive regulation of cardiac muscle cell differentiation MAPK cascade negative regulation of protein phosphorylation positive regulation of protein phosphorylation protein phosphorylation cell cycle arrest mitotic cell cycle checkpoint epidermal growth factor receptor signaling pathway common-partner SMAD protein phosphorylation SMAD protein complex assembly positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation cell migration regulation of transforming growth factor beta receptor signaling pathway negative regulation of cell-cell adhesion positive regulation of bone mineralization positive regulation of histone deacetylation lipopolysaccharide-mediated signaling pathway positive regulation of cellular protein metabolic process positive regulation of peptidyl-serine phosphorylation positive regulation of histone acetylation positive regulation of protein dephosphorylation myeloid dendritic cell differentiation positive regulation of MAP kinase activity protein kinase B signaling positive regulation of phosphatidylinositol 3-kinase activity ossification involved in bone remodeling negative regulation of cytolysis negative regulation of mitotic cell cycle positive regulation of peptidyl-tyrosine phosphorylation regulation of binding regulation of DNA binding pathway-restricted SMAD protein phosphorylation regulation of SMAD protein import into nucleus positive regulation of cell cycle arrest cellular response to organic cyclic compound positive regulation of NAD+ ADP-ribosyltransferase activity negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of receptor clustering transforming growth factor beta receptor signaling pathway involved in heart development regulation of actin cytoskeleton reorganization positive regulation of transcription regulatory region DNA binding protein import into nucleus, translocation regulation of cell growth SMAD protein import into nucleus aging negative regulation of DNA replication response to radiation defense response to fungus, incompatible interaction response to organic substance response to organic cyclic compound cell growth evasion or tolerance of host defenses by virus lung development wound healing response to drug regulation of MAPK cascade negative regulation of immune response positive regulation of NF-kappaB transcription factor activity SMAD protein signal transduction negative regulation of gene silencing by miRNA regulation of miRNA metabolic process skeletal system development CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment defense response skeletal muscle tissue development organ morphogenesis regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation growth regulation of apoptotic process cell development T-helper 17 cell lineage commitment
          It has to be done as per old AB suggested Products section.

          Disclaimer

          Close

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
          help_icon

          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

          Contact tech support
          Ordering Plus Icon Minus Icon
          • Order Status
          • Order Help
          • Quick Order
          • Supply Center
          • eProcurement
          Support Plus Icon Minus Icon
          • Help and Support
          • Contact Us
          • Technical Support Centers
          • Documents and Certificates
          • Report a Site Issue
          Resources Plus Icon Minus Icon
          • Learning Centers
          • Promotions
          • Events and Webinars
          • Social Media
          About Thermo Fisher Plus Icon Minus Icon
          • About Us About Us
          • Careers Careers
          • Investors Investors
          • News News
          • Social Responsibility Social Responsibility
          • Trademarks
          • Consumer Health Data Privacy Policy Consumer Health Data Privacy Policy
          • Policies and Notices
          Our Portfolio Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Fisher Scientific
          • Unity Lab Services
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Notice
          • Price & Freight Policy
          © 2006-2026 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          United States flag icon
          United States

          Your items have has been added!


          Host server : magellan-search-green-7d94cb4b65-4lm45:80/100.66.75.98:80.
          git-commit: c9e08c96761173abe34e68f880379696776a4827
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.44.1-2026.02.97.1.0