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Invitrogen
cIAP1 Polyclonal Antibody
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FIGURE: 1 / 5
cIAP1 Antibody (PA5-20066) in IHC (P)
Immunohistochemical analysis of paraffin-embedded human lung tissue using cIAP1 Polyclonal Antibody (Product # PA5-20066) at 10 µg/mL. Tissue was fixed with formaldehyde and blocked with 0.1 serum for 1 h at RT; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody overnight at 4˚C. A goat anti-rabbit IgG H&L (HRP) at 1/250 was used as secondary. C... View More
Product Details
PA5-20066
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to 14 amino acids at the C-terminus of human c-IAP1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects both c-IAP1 and c-IAP2.
A suggested positive control is human lung tissue lysate.
PA5-20066 can be used with blocking peptide PEP-0185.
Target Information
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: apoptosis inhibitor 1; apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 2; C-IAP1; Cellular inhibitor of apoptosis 1; hIAP-2; IAP homolog B; IAP-2; Inhibitor of apoptosis protein 2; mIAP-2; mIAP2; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2; unnamed protein product
Gene Aliases: API1; Api2; AW146227; BIRC2; Birc3; c-IAP1; cIAP1; cIAP2; Hiap-2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; RNF48
UniProt ID: (Human) Q13490, (Mouse) Q62210
Entrez Gene ID: (Human) 329, (Mouse) 11797
transcription coactivator activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
ubiquitin binding
macromolecular complex binding
metal ion binding
chaperone binding
ubiquitin protein ligase activity
FBXO family protein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein N-terminus binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
protease inhibitor
protein polyubiquitination
response to hypoxia
placenta development
apoptotic process
cell surface receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
positive regulation of protein ubiquitination
tumor necrosis factor-mediated signaling pathway
regulation of toll-like receptor signaling pathway
NIK/NF-kappaB signaling
regulation of RIG-I signaling pathway
regulation of cell proliferation
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of innate immune response
response to ethanol
regulation of cell differentiation
positive regulation of transcription, DNA-templated
regulation of inflammatory response
response to cAMP
regulation of cell cycle
regulation of necroptotic process
negative regulation of necroptotic process
necroptotic process
regulation of nucleotide-binding oligomerization domain containing signaling pathway
cellular response to tumor necrosis factor
regulation of NIK/NF-kappaB signaling
negative regulation of ripoptosome assembly involved in necroptotic process
positive regulation of protein K63-linked ubiquitination
positive regulation of protein K48-linked ubiquitination
positive regulation of protein monoubiquitination
positive regulation of protein polyubiquitination
response to bleomycin
regulation of reactive oxygen species metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
protein ubiquitination
protein heterooligomerization
regulation of nucleic acid-templated transcription
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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