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Aldo-keto Reductase Family 1 Member C2/DD2 Monoclonal Antibody (CPTC-AKR1C2-1)
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FIGURE: 1 / 5
Aldo-keto Reductase Family 1 Member C2/DD2 Antibody (1646-MSM1-P1ABX) in IHC (P)
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human prostate carcinoma using Aldo-keto Reductase Family 1 Member C2, DD2 Monoclonal Antibody (Product # 1646-MSM1-P1ABX).
Product Details
1646-MSM1-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
CPTC-AKR1C2-1
Immunogen
Recombinant human full-length AKR1C2 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
DD1 is also designated AKR1C1, DDH or DDH1, while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3 alpha-HSD are alternate designations for human DD3 (which is referred to as AKR1C18 in rodents), while DD4 also can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents). DD1 and DD2 are 20 alpha-HSDs, whereas DD3 and DD4 are the 3 alpha- HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20 alpha- HSD catalyzes the reaction of Progesterone to the inactive form 20 alpha-hydroxyprogesterone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3 alpha-HSD3; 3-alpha-HSD3; Aldo-keto reductase family 1 member C2; chlordecone reductase homolog; Chlordecone reductase homolog HAKRD; DD-2; DD/BABP; Dihydrodiol dehydrogenase 2; dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III; Dihydrodiol dehydrogenase/bile acid-binding protein; HSD3-3 alpha; HSD3-alpha3; pseudo-chlordecone reductase; testicular 17,20-desmolase deficiency; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II dihydrodiol dehydrogenase; Type III 3-alpha-hydroxysteroid dehydrogenase; unnamed protein product
Gene Aliases: AKR1C-pseudo; AKR1C2; BABP; DD; DD-2; DD/BABP; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD
UniProt ID: (Human) P52895
Entrez Gene ID: (Human) 1646
alditol:NADP+ 1-oxidoreductase activity
estradiol 17-beta-dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
carboxylic acid binding
bile acid binding
androsterone dehydrogenase activity
androstan-3-alpha,17-beta-diol dehydrogenase activity
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
indanol dehydrogenase activity
alcohol metabolic process
lipid metabolic process
prostaglandin metabolic process
G-protein coupled receptor signaling pathway
digestion
steroid metabolic process
positive regulation of cell proliferation
epithelial cell differentiation
monocarboxylic acid metabolic process
hormone metabolic process
progesterone metabolic process
daunorubicin metabolic process
doxorubicin metabolic process
positive regulation of protein kinase B signaling
cellular response to jasmonic acid stimulus
cellular response to prostaglandin D stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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