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Proteintech

SHP1 Polyclonal Antibody

17 References
View all (52) SHP-1 antibodies

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Product Details

24546-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 12 publications 12 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

1:10-1:100
View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg
View 3 publications 3 publications
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SHP1 Fusion Protein Ag21415 (506-598 aa encoded by BC002523)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Amount

49.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QYKFIYVAI AQFIETTKKK LEVLQSQKGQ ESEYGNITYP PAMKNAHAKA SRTSSKHKED VYENLHTKNK REEKVKKQRS ADKEKSKGSL KRK (506-598 aa encoded by BC002523)

Target Information

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: EC 3.1.3.48; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; SH-PTP1; Tyrosine-protein phosphatase non-receptor type 6; unnamed protein product

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Gene Aliases: HCP; HCPH; HPTP1C; PTP-1C; PTP1C; PTPN6; SH-PTP1; SHP-1; SHP-1L; SHP1

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UniProt ID: (Human) P29350

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Entrez Gene ID: (Human) 5777

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Function(s)
phosphotyrosine binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding hydrolase activity SH3 domain binding protein kinase binding SH2 domain binding cell adhesion molecule binding phosphorylation-dependent protein binding
Process(es)
MAPK cascade mitotic cell cycle pattern recognition receptor signaling pathway hematopoietic progenitor cell differentiation neutrophil activation involved in immune response cytoplasmic pattern recognition receptor signaling pathway negative regulation of humoral immune response mediated by circulating immunoglobulin protein dephosphorylation G-protein coupled receptor signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of angiogenesis peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cell differentiation platelet formation T cell costimulation negative regulation of lipopolysaccharide-mediated signaling pathway negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of mast cell activation involved in immune response positive regulation of cell adhesion mediated by integrin peptidyl-tyrosine dephosphorylation intracellular signal transduction megakaryocyte development T cell proliferation T cell activation negative regulation of T cell proliferation natural killer cell mediated cytotoxicity regulation of apoptotic process negative regulation of MAPK cascade regulation of B cell differentiation positive regulation of angiogenesis negative regulation of innate immune response T cell receptor signaling pathway B cell receptor signaling pathway negative regulation of B cell receptor signaling pathway negative regulation of T cell receptor signaling pathway regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling regulation of type I interferon-mediated signaling pathway regulation of ERK1 and ERK2 cascade platelet aggregation inflammatory response to wounding negative regulation of inflammatory response to wounding CD27 signaling pathway positive regulation of cytokine production involved in inflammatory response negative regulation of neutrophil activation epididymis development regulation of G1/S transition of mitotic cell cycle
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