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Bethyl Laboratories
CoCoA Polyclonal Antibody
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FIGURE: 1 / 1
CoCoA Antibody (A300-818A) in WB
Detection of human and mouse CoCoA by western blot (h&m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (H; 50 µg), HEK293T (T; 50 µg), NIH 3T3 (N; 50 µg), Ramos (R; 50 µg), and MCF-7 (M; 50 µg for WB; 1 mg for IP, 20% of IP loaded) cells. Antibodies: Affinity purified rabbit anti-CoCoA antibody BL2456 (Product # A300-818A) used for WB at 0.4 µg/mL (A) and 1 µg/mL (B) and used for IP at 3 µg/mg lysate (B). CoCoA was also immunoprecipitated by rabbit anti-CoCoA antibody BL2455 (Product #A300-817A), which recognizes an ups... View More
Product Details
A300-818A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 650 and the C-terminus (residue 691) of human Coiled-Coil Transcriptional Coactivator 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat and Orangutan
Target Information
CALCOCO1 (calcium-binding and coiled-coil domain-containing protein 1), also known as cocoa, calphoglin, sarcoma antigen NY-SAR-3 or coiled-coil coactivator protein, is a 691 amino acid protein that shuttles between the cytoplasm and nucleus and functions as coactivator for aryl hydrocarbon and nuclear receptors. A member of the CALCOCO family, CALCOCO1 is forms a calphoglin complex with PPA1 and PGM 1 and contains multiple functional domains through which it acts as a component of both the androgen signaling pathway and the Wnt/beta-catenin signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium-binding and coiled-coil domain-containing protein 1; Calphoglin; Coiled-coil coactivator protein; coiled-coil leucine zipper coactivator 1; coiled-coil transcriptional coactivator; granule cell antiserum positive 11; GRIP1-interacting protein; inorganic pyrophosphatase activator; KIAA1536; Sarcoma antigen NY-SAR-3; unnamed protein product
Gene Aliases: 1810009B06Rik; CALCOCO1; calphoglin; CocoA; Gcap11; KIAA1536; mKIAA1536; PP13275; UNQ2436/PRO4996
UniProt ID: (Human) Q9P1Z2, (Mouse) Q8CGU1
Entrez Gene ID: (Human) 57658, (Mouse) 67488
RNA polymerase II core promoter proximal region sequence-specific DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
protein binding
beta-catenin binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
protein C-terminus binding
ligand-dependent nuclear receptor transcription coactivator activity
transcription regulatory region DNA binding
armadillo repeat domain binding
signal transduction
positive regulation of gene expression
Wnt signaling pathway
intracellular steroid hormone receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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