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Invitrogen
TOM70 Recombinant Rabbit Monoclonal Antibody (PSH13-00)
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FIGURE: 1 / 11
TOM70 Antibody (MA570002) in ICC/IF
Immunocytochemistry analysis of TOM70 in NIH/3T3 cells. Samples were incubated with TOM70 monoclonal antibody (Product # MA570002) using a dilution of 1:100 in 1% BSA in PBST overnight at 4°C followed by Goat Anti-Rabbit IgG H&L (iFluor™ 488) at a dilution of 1:1,000. Cells were fixed in 4% paraformaldehyde for 15 minutes at room temperature, permeabilized with 0.1% Triton X-100 in PBS for 15 minutes at room temperature, then blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. PBS instead of the primary antibody ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA570002
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PSH13-00
Immunogen
Recombinant protein within human TOM70 aa 86-608.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
Contains
0.2% ProClin 950
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: MCF7 cell lysate, HeLa cell lysate, HepG2 cell lysate, Jurkat cell lysate, MDA-MB-231 cell lysate, NIH/3T3 cell lysate, 4T1 cell lysate, C6 cell lysate, PC-12 cell lysate, COS-1 cell lysate, human colon tissue, mouse colon tissue, rat colon tissue.
Subcellular location: Mitochondrion outer membrane.
Target Information
Functional mitochondria require up to 1000 proteins to function properly, with 99% synthesized as precursors in the cytoplasm and transported into the mitochondria with the aid of cytosolic chaperones and mitochondrial translocators (import components). Proteins to be imported are chaperoned to the mitochondria by the cytosolic heat shock protein (cHSP70) and are immediately pursued by Translocators of the Outer Membrane (TOMs), followed by transient interactions of the unfolded proteins with Translocators of the Inner Membrane (TIMs). TOMM70A is ubiquitously expressed in human tissues and localizes in the mitochondria. TOMM70A could play a significant role in the import of nuclear-encoded mitochondrial proteins with internal targeting sites such as ADP/ATP carriers and the uncoupling proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ90470; mitochondrial precursor proteins import receptor; translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane 70 homolog A; translocase of outer mitochondrial membrane protein 70; unnamed protein product
Gene Aliases: 2610044B22Rik; D16Ium22; D16Ium22e; D16Wsu109e; mKIAA0719; TOM70; Tomm70; TOMM70A
UniProt ID: (Human) O94826, (Rat) Q75Q39, (Mouse) Q9CZW5
Entrez Gene ID: (Human) 9868, (Rat) 304017, (Mouse) 28185
activation of innate immune response
positive regulation of defense response to virus by host
protein import into mitochondrial matrix
positive regulation of interferon-beta production
regulation of apoptotic process
protein import into mitochondrial inner membrane
negative regulation of cell growth involved in cardiac muscle cell development
response to thyroxine
cellular response to virus
positive regulation of establishment of protein localization to mitochondrion
protein import into mitochondrial outer membrane
protein localization to mitochondrion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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