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Invitrogen
CHMP2B Polyclonal Antibody
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Product Details
PA5-109532
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human CHMP2B (NP_054762.2).
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
28 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MASLFKKKTV DDVIKEQNRE LRGTQRAIIR DRAALEKQEK QLELEIKKMA KIGNKEACKV LAKQLVHLRK QKTRTFAVSS KVTSMSTQTK VMNSQMKMAG AMSTTAKTMQ AVNKKMDPQK TLQTMQNFQK ENMKMEMTEE MINDTLDDIF DGSDDEEESQ DIVNQVLDEI GIEISGKMAK APSAARSLPS ASTSKATISD EEIERQLKAL GVD
Target Information
CHMP2B, also known as CHMP2.5 or vacuolar protein-sorting-associated protein 2-2, is a 213 amino acid cytosolic protein. Widely expressed in brain, heart, skeletal muscle, small intestine, pancreas, lung, placenta and leukocytes, CHMP2B associates directly with CHMP2A and vps4 for the disassembly of the ESCRT-III complex. Defects in the gene encoding CHMP2B have been shown to cause chromosome 3-linked frontotemporal dementia (FTD3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Charged multivesicular body protein 2b; CHMP family; CHMP2.5; CHMP2b; chromatin modifying protein 2B; Chromatin-modifying protein 2b; DKFZP564O123; hVps2-2; unnamed protein product; Vacuolar protein sorting-associated protein 2-2; vacuolar protein-sorting-associated protein 2-2; VPS2 homolog B; Vps2-2
Gene Aliases: 1190006E07Rik; ALS17; CGI-84; CHMP2.5; CHMP2B; DMT1; FTDALS7; VPS2-2; VPS2B
UniProt ID: (Human) Q9Y4U6, (Mouse) Q8BJF9
Entrez Gene ID: (Human) 25978, (Mouse) 68942
plasma membrane repair
autophagy
nucleus organization
endosome organization
vacuolar transport
mitotic metaphase plate congression
regulation of centrosome duplication
protein transport
macroautophagy
viral release from host cell
nuclear envelope reassembly
endosome transport via multivesicular body sorting pathway
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
late endosome to vacuole transport
viral budding from plasma membrane
modulation of synaptic transmission
cognition
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
neuron cellular homeostasis
multivesicular body sorting pathway
membrane fission
autophagosome maturation
regulation of modification of postsynaptic structure
regulation of postsynapse organization
regulation of mitotic spindle assembly
late endosome to lysosome transport
ESCRT III complex disassembly
cell separation after cytokinesis
transport
positive regulation of viral release from host cell
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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