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Invitrogen
p38 MAPK beta Polyclonal Antibody
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FIGURE: 1 / 4
p38 MAPK beta Antibody (PA5-81217) in ICC/IF
Immunofluorescence staining of p38 MAPK beta in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with p38 MAPK beta Polyclonal Antibody (Product # PA5-81217, 1:1,000) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cytopl... View More
Product Details
PA5-81217
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human MAPK11
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human MAPK11.
Target Information
MAPK11 (p38 beta) is a serine/threonine kinase which is involved in a variety of cellular processes, and is activated by proinflammatory cytokines and environmental stress. Mitogen-activated protein kinase 11. The protein encoded by p38 MAPK beta is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP kinase 11; MAP kinase p38 beta; MAP kinase p38-2; MAPK11; Mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; OTTHUMP00000196655; p38-2; SAPK2b; splicing isoform of p38Beta MAP Kinase; Stress-activated protein kinase 2b; stress-activated protein kinase-2; stress-activated protein kinase-2b; unnamed protein product
Gene Aliases: MAPK11; p38-2; P38B; p38Beta; P38BETA2; PRKM11; SAPK2; SAPK2B
UniProt ID: (Human) Q15759
Entrez Gene ID: (Human) 5600
MAPK cascade
osteoblast differentiation
positive regulation of gene expression
stress-activated protein kinase signaling cascade
positive regulation of interleukin-12 production
intracellular signal transduction
p38MAPK cascade
positive regulation of erythrocyte differentiation
positive regulation of muscle cell differentiation
stress-activated MAPK cascade
protein maturation
cardiac muscle cell proliferation
regulation of cardiac muscle cell proliferation
negative regulation of cardiac muscle cell proliferation
bone development
pyroptosis
cellular response to interleukin-1
cellular response to UV-B
cellular senescence
cellular response to virus
NLRP1 inflammasome complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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