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Invitrogen
Equine IL-2 Recombinant Protein
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Product Details
REIL2I
Product Specifications
Class
Recombinant
Type
Protein
Conjugate
Form
Lyophilized
Amount
20 µg
Storage conditions
4°C
Shipping conditions
Wet ice
Product Specific Information
For dilution, use a buffer containing carrier protein, e.g. PBS with 1% BSA or a neutral media containing 10% FCS and freeze in aliquots at -70°C.
Activity: The biological activity of recombinant equine IL-2 was determined by measuring the proliferation of mouse CTLL-2 cells. The ED50 (or 1 unit of activity) for this effect in our laboratories is typically 2 µg/mL. Ref: Kaye, J. and C.A. Janeway. (1984) Lymphokine Res. 3:175.
Mature equine IL-2 was expressed in Pichia pastoris, X-33. GenBank® Accession # P37997, amino acids 21 - 149. For protein verification, the expressed protein was N-terminal sequenced and begins with the following 10 amino acids: APTSSSKRET.
Reconstitute with 0.5 mL of distilled water.
Target Information
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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