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Invitrogen
Human ADAMTS4 Recombinant Protein
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Product Details
RP-77540
Product Specifications
Expression System
Insect cells
Class
Recombinant
Type
Protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
5 µg
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
RP-77540 is a purified partial recombinant human ADAMTS4 protein expressed in insect cells. RP-77540 may be used as a control with corresponding anti-ADAMTS4 antibodies.
Target Information
This gene encodes a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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