Product References
Gram-positive anaerobic cocci guard skin homeostasis by regulating host-defense mechanisms.
iScience
van der Krieken DA,Rikken G,Ederveen THA,Jansen PAM,Rodijk-Olthuis D,Meesters LD,van Vlijmen-Willems IMJJ,van Cranenbroek B,van der Molen RG,Schalkwijk J,van den Bogaard EH,Zeeuwen PLJM
300-49 was used in Enzyme-linked immunosorbent assay to report that, through secreted soluble factors, GPAC rapidly and directly induced epidermal host-defense molecules in cultured human keratinocytes and indirectly via immune-cell activation and cytokines derived thereof.
Fri Apr 21 00:00:00 EDT 2023
Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis.
Scientific reports
Ting DSJ,Goh ETL,Mayandi V,Busoy JMF,Aung TT,Periayah MH,Nubile M,Mastropasqua L,Said DG,Htoon HM,Barathi VA,Beuerman RW,Lakshminarayanan R,Mohammed I,Dua HS
Wed Sep 15 00:00:00 EDT 2021
Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells.
Cells
Ho J,Wickramasinghe DN,Nikou SA,Hube B,Richardson JP,Naglik JR
300-49 was used in Enzyme-linked immunosorbent assay to provide novel mechanistic insight into the induction of multiple key alarmins and AMPs, important for antifungal defences against C. albicans.
Thu Mar 12 00:00:00 EDT 2020
Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2.
Mucosal immunology
Cobo ER,Kissoon-Singh V,Moreau F,Chadee K
Sun Nov 01 00:00:00 EDT 2015
β-defensin-2 in breast milk displays a broad antimicrobial activity against pathogenic bacteria.
Jornal de pediatria
Baricelli J,Rocafull MA,Vázquez D,Bastidas B,Báez-Ramirez E,Thomas LE
300-49 was used in Enzyme-linked immunosorbent assay to report β-defensin-2 levels in Latin American women. The production and the activity of β-defensin-2 in breast milk prove its importance as a defense molecule for intestinal health in pediatric patients.
Tue Jul 28 00:00:00 EDT 2015
pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37.
Proceedings of the National Academy of Sciences of the United States of America
Abou Alaiwa MH,Reznikov LR,Gansemer ND,Sheets KA,Horswill AR,Stoltz DA,Zabner J,Welsh MJ
Tue Dec 30 00:00:00 EST 2014
β-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-α production by human plasmacytoid dendritic cells, and promote inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Tewary P,de la Rosa G,Sharma N,Rodriguez LG,Tarasov SG,Howard OM,Shirota H,Steinhagen F,Klinman DM,Yang D,Oppenheim JJ
Mon Jul 15 00:00:00 EDT 2013
Identification and characterization of bacterial vaginosis-associated pathogens using a comprehensive cervical-vaginal epithelial coculture assay.
PloS one
Eade CR,Diaz C,Wood MP,Anastos K,Patterson BK,Gupta P,Cole AL,Cole AM
Mon Apr 29 00:00:00 EDT 2013
Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization.
Nature
Iwase T,Uehara Y,Shinji H,Tajima A,Seo H,Takada K,Agata T,Mizunoe Y
Thu May 20 00:00:00 EDT 2010
Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis.
Journal of immunology (Baltimore, Md. : 1950)
Guilloteau K,Paris I,Pedretti N,Boniface K,Juchaux F,Huguier V,Guillet G,Bernard FX,Lecron JC,Morel F
Sat May 01 00:00:00 EDT 2010
Attraction and activation of dendritic cells at the site of tumor elicits potent antitumor immunity.
Molecular therapy : the journal of the American Society of Gene Therapy
Lapteva N,Aldrich M,Rollins L,Ren W,Goltsova T,Chen SY,Huang XF
Tue Sep 01 00:00:00 EDT 2009
Streptococcus agalactiae CspA is a serine protease that inactivates chemokines.
Journal of bacteriology
Bryan JD,Shelver DW
Sun Mar 01 00:00:00 EST 2009
CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells.
The Journal of biological chemistry
Vongsa RA,Zimmerman NP,Dwinell MB
Fri Apr 10 00:00:00 EDT 2009
Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin.
PloS one
Jansen PA,Rodijk-Olthuis D,Hollox EJ,Kamsteeg M,Tjabringa GS,de Jongh GJ,van Vlijmen-Willems IM,Bergboer JG,van Rossum MM,de Jong EM,den Heijer M,Evers AW,Bergers M,Armour JA,Zeeuwen PL,Schalkwijk J
Mon May 11 00:00:00 EDT 2009
Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response.
Immunology and cell biology
Pingel LC,Kohlgraf KG,Hansen CJ,Eastman CG,Dietrich DE,Burnell KK,Srikantha RN,Xiao X,Bélanger M,Progulske-Fox A,Cavanaugh JE,Guthmiller JM,Johnson GK,Joly S,Kurago ZB,Dawson DV,Brogden KA
Mon Jun 01 00:00:00 EDT 2009
Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis.
Journal of immunology (Baltimore, Md. : 1950)
Kryczek I,Bruce AT,Gudjonsson JE,Johnston A,Aphale A,Vatan L,Szeliga W,Wang Y,Liu Y,Welling TH,Elder JT,Zou W
Wed Oct 01 00:00:00 EDT 2008
Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii.
Journal of immunology (Baltimore, Md. : 1950)
Aronoff DM,Hao Y,Chung J,Coleman N,Lewis C,Peres CM,Serezani CH,Chen GH,Flamand N,Brock TG,Peters-Golden M
Sun Jun 15 00:00:00 EDT 2008
Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii.
Journal of immunology (Baltimore, Md. : 1950)
Aronoff DM,Hao Y,Chung J,Coleman N,Lewis C,Peres CM,Serezani CH,Chen GH,Flamand N,Brock TG,Peters-Golden M
Sun Jun 15 00:00:00 EDT 2008
Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappaB-mediated innate antiviral response against human respiratory syncytial virus.
The Journal of biological chemistry
Kota S,Sabbah A,Chang TH,Harnack R,Xiang Y,Meng X,Bose S
Fri Aug 15 00:00:00 EDT 2008
Haemophilus ducreyi is resistant to human antimicrobial peptides.
Antimicrobial agents and chemotherapy
Mount KL,Townsend CA,Bauer ME
Sat Sep 01 00:00:00 EDT 2007
Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa.
Experimental eye research
Maltseva IA,Fleiszig SM,Evans DJ,Kerr S,Sidhu SS,McNamara NA,Basbaum C
Sun Jul 01 00:00:00 EDT 2007
Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C).
Journal of immunology (Baltimore, Md. : 1950)
Schaefer TM,Fahey JV,Wright JA,Wira CR
Sat Jan 15 00:00:00 EST 2005
Expression and activity of beta-defensins and LL-37 in the developing human lung.
Journal of immunology (Baltimore, Md. : 1950)
Starner TD,Agerberth B,Gudmundsson GH,McCray PB
Tue Feb 01 00:00:00 EST 2005
Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms.
Journal of clinical microbiology
Joly S,Maze C,McCray PB,Guthmiller JM
Mon Mar 01 00:00:00 EST 2004
Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation.
Infection and immunity
Starner TD,Swords WE,Apicella MA,McCray PB
Sun Sep 01 00:00:00 EDT 2002
The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus.
The Journal of biological chemistry
Schibli DJ,Hunter HN,Aseyev V,Starner TD,Wiencek JM,McCray PB,Tack BF,Vogel HJ
Fri Mar 08 00:00:00 EST 2002
Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.
Protein science : a publication of the Protein Society
Bauer F,Schweimer K,Klüver E,Conejo-Garcia JR,Forssmann WG,Rösch P,Adermann K,Sticht H
Sat Dec 01 00:00:00 EST 2001
The structure of human beta-defensin-2 shows evidence of higher order oligomerization.
The Journal of biological chemistry
Hoover DM,Rajashankar KR,Blumenthal R,Puri A,Oppenheim JJ,Chertov O,Lubkowski J
Fri Oct 20 00:00:00 EDT 2000
