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Invitrogen
Human CENPW Synthetic Peptide
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Product Details
PEP-1483
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human CENPW.
PEP-1483 can be used as a blocking peptide with polyclonal antibody PA5-34441.
Target Information
CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer-up-regulated gene 2 protein; cancer-upregulated gene; cancer-upregulated gene 2; CANP-W; CENP-W; Centromere protein W
Gene Aliases: C6orf173; CENP-W; CENPW; CUG2
UniProt ID: (Human) Q5EE01
Entrez Gene ID: (Human) 387103
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