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Invitrogen
Human DRAM Synthetic Peptide
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Product Details
PEP-0456
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 16 amino acid peptide from near the amino terminus of human DRAM
PEP-0456 can be used as a blocking peptide with polyclonal antibody PA5-20336.
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Damage-regulated autophagy modulator; DNA damage-regulated autophagy modulator protein 1; DNA-damage regulated autophagy modulator 1; FLJ11259
Gene Aliases: DRAM; DRAM1
UniProt ID: (Human) Q8N682
Entrez Gene ID: (Human) 55332
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