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Invitrogen
Human DUSP12 (aa 165-313) Control Fragment Recombinant Protein
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Product Details
RP-89148
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
YQAMGYEVDTSSAIYKQYRLQKVTEKYPELQNLPQELFAVDPTTVSQGLKDEVLYKCRKCRRSLFRSSSILDHREGSGPIAFAHKRMTPSSMLTTGRQAQCTSYFIEPVQWMESALLGVMDGQLLCPKCSAKLGSFNWYGEQCSCGRWI
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (89%), Rat (89%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-110753. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Dual specificity phosphatase (DUSP) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs can be divided into six subgroups on the basis of sequence similarity (PRLs, Cdc14 phosphatases, PTENs, myotubularins, MKPs, atypical DUSPs). DUSP inhibitors might be used to manipulate MAPK and cellular responses in both positive and negative ways. The regulated expression and activity of DUSP family members in different cells and tissues controls MAPK intensity and duration to determine the type of physiological response. DUSP12 (YVH1, GKAP) contains the consensus DUSP catalytic domain as well as an extended C-terminal domain of unknown function, thought to be related to its potential role in glucokinase regulation. It is localized in the cytoplasm and nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 12; Dual specificity tyrosine phosphatase YVH1; serine/threonine specific protein phosphatase; YVH1 protein-tyrosine phosphatase ortholog
Gene Aliases: DUSP1; DUSP12; YVH1
UniProt ID: (Human) Q9UNI6
Entrez Gene ID: (Human) 11266
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