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Human ENA-78 (CXCL5) (5-78 aa) Recombinant Protein, PeproTech®

Human ENA-78 (CXCL5) (5-78 aa) Protein in Functional Assay (Functional)

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Human ENA-78 (CXCL5) (5-78 aa) Protein (300-22-100UG) in Functional

Bioassay analysis of Human ENA-78 (CXCL5) (5-78 aa) Recombinant Protein, PeproTech® (Product # 300-22-1MG).

Product Image Gallery

Product Details

300-22-100UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 13 publications 13 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species

Human

Published species

Bacteria, Hamster, Human, Mouse

Expression System

E. coli

Amino acid sequence

AAVLRELRCV CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN

Molecular weight

8 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration of 5.0-10.0 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human ENA-78 is an 8.0 kDa protein consisting of 74 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

The protein encoded by this gene is an inflammatory chemokine that belongs to the CXC chemokine family. This chemokine is produced concomitantly with interleukin-8 (IL8) in response to stimulation with either interleukin-1 (IL1) or tumor necrosis factor-alpha (TNFA). This chemokine is a potent chemotaxin involved in neutrophil activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

mRNA-engineered mesenchymal stromal cells expressing CXCR2 enhances cell migration and improves recovery in IBD.

Molecular therapy. Nucleic acids

Li Q,Lian Y,Deng Y,Chen J,Wu T,Lai X,Zheng B,Qiu C,Peng Y,Li W,Xiang AP,Zhang X,Ren J

Fri Dec 03 00:00:00 EST 2021

Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils.

Mucosal immunology

Fonseca KL,Maceiras AR,Matos R,Simoes-Costa L,Sousa J,Cá B,Barros L,Fernandes AI,Mereiter S,Reis R,Gomes J,Tapia G,Rodríguez-Martínez P,Martín-Céspedes M,Vashakidze S,Gogishvili S,Nikolaishvili K,Appelberg R,Gärtner F,Rodrigues PNS,Vilaplana C,Reis CA,Magalhães A,Saraiva M

Tue Sep 01 00:00:00 EDT 2020

A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.

The Journal of biological chemistry

Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S

Fri Jul 19 00:00:00 EDT 2019

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α.

Nature communications

Wang Q,He Z,Huang M,Liu T,Wang Y,Xu H,Duan H,Ma P,Zhang L,Zamvil SS,Hidalgo J,Zhang Z,O'Rourke DM,Dahmane N,Brem S,Mou Y,Gong Y,Fan Y

Thu Feb 08 00:00:00 EST 2018

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.

Scientific reports

Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S

Fri Apr 20 00:00:00 EDT 2018

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Scientific reports

Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S

Tue Jun 27 00:00:00 EDT 2017

Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop.

Scientific reports

Kechagia JZ,Ezra DG,Burton MJ,Bailly M

Mon Jun 20 00:00:00 EDT 2016

Host chemokines bind to Staphylococcus aureus and stimulate protein A release.

The Journal of biological chemistry

Yung SC,Parenti D,Murphy PM

Fri Feb 18 00:00:00 EST 2011

The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist.

The Journal of biological chemistry

Lüttichau HR

Fri Mar 19 00:00:00 EDT 2010

SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.

PloS one

Egesten A,Olin AI,Linge HM,Yadav M,Mörgelin M,Karlsson A,Collin M

Mon Jun 15 00:00:00 EDT 2009

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.

The Journal of experimental medicine

Proost P,Loos T,Mortier A,Schutyser E,Gouwy M,Noppen S,Dillen C,Ronsse I,Conings R,Struyf S,Opdenakker G,Maudgal PC,Van Damme J

Mon Sep 01 00:00:00 EDT 2008

Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus.

The Journal of biological chemistry

Hirata T,Furukawa Y,Yang BG,Hieshima K,Fukuda M,Kannagi R,Yoshie O,Miyasaka M

Fri Dec 10 00:00:00 EST 2004

The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro.

Stem cells (Dayton, Ohio)

Majka M,Ratajczak J,Lee B,Honczarenko M,Douglas R,Kowalska MA,Silberstein L,Gewirtz AM,Ratajczak MZ

Mon Jun 26 00:00:00 EDT 2000

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions.

Nature

Gerszten RE,Garcia-Zepeda EA,Lim YC,Yoshida M,Ding HA,Gimbrone MA,Luster AD,Luscinskas FW,Rosenzweig A

Thu Apr 22 00:00:00 EDT 1999

Mast cell migratory response to interleukin-8 is mediated through interaction with chemokine receptor CXCR2/Interleukin-8RB.

Blood

Nilsson G,Mikovits JA,Metcalfe DD,Taub DD

Sat May 01 00:00:00 EDT 1999

Bioinformatics

Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 5; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 5; CXC; CXC motif chemokine; CXCL; ENA-78(1-78); Epithelial-derived neutrophil-activating protein 78; Neutrophil-activating peptide ENA-78; neutrophil-activating protein 78; small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78); Small-inducible cytokine B5

Human ENA-78 (CXCL5) (5-78 aa) Recombinant Protein, PeproTech®

Human ENA-78 (CXCL5) (5-78 aa) Protein (300-22-100UG) in Functional

Product Details

300-22-100UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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