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Product Details
PEP-1405
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 19 amino acids near the amino terminus of human ESRRB.
PEP-1405 can be used as a blocking peptide with polyclonal antibody PA5-34362.
Target Information
ESRRB (steroid hormone receptor ERR2) plays a role in maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERR beta-2; ERR-beta; ERRbeta; ERRbeta-2; Estrogen receptor-like 2; estrogen-related nuclear receptor beta; Estrogen-related receptor beta; nuclear receptor ERRB2; Nuclear receptor subfamily 3 group B member 2; orphan nuclear receptor; Steroid hormone receptor ERR2
Gene Aliases: DFNB35; ERR2; ERRb; ERRB2; ESRL2; ESRRB; NR3B2
UniProt ID: (Human) O95718
Entrez Gene ID: (Human) 2103
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