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          • Proteins & Peptides ›
          • Endostatin Proteins
          The PeproTech website has now moved to Thermofisher.com. All orders for PeproTech products must be placed on thermofisher.com or offline via phone, fax, email, or distributor partner. For any questions, please contact PeproTech.CustomerService@thermofisher.com

          Gibco

          Human Endostatin Recombinant Protein, PeproTech®

          1 Reference
          View all (3) Endostatin proteins

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          Datasheet
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          Cite Human Endostatin Recombinant Protein, PeproTech®

          • Testing Data (1)
          Human Endostatin Protein in Functional Assay (Functional)
          Group 53 Created with Sketch.
          Human Endostatin Protein in Functional Assay (Functional)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          Human Endostatin Protein (150-01-100UG) in Functional

          Bioassay analysis of Human Endostatin Recombinant Protein, PeproTech® (Product # 150-01-1MG). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Human Endostatin Protein in Functional Assay (Functional)

          Product Details

          150-01-100UG

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          -

          ELISA (ELISA)

          Assay-dependent
          -

          Functional Assay (Functional)

          Assay-dependent
          -

          In vitro Assay (IV)

          -
          View 1 publication 1 publication
          Product Specifications

          Species

          Human

          Published species

          Human

          Expression System

          E. coli

          Amino acid sequence

          MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK

          Molecular weight

          20.2 kDa

          Class

          Recombinant

          Type

          Protein

          Purity

          ≥ 98% by SDS-PAGE gel and HPLC analyses.

          Endotoxin concentration

          <1 EU/µg

          Activity

          Measured by its ability to inhibit HUVEC migration.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Purification

          purified

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient

          Product Specific Information

          Recombinant Human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.

          This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

          Target Information

          Endostatin is able to avoke non-uniform response for proliferation, cell mount and migration of entothelial cells, which different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type. Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells. The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality. Tumor cell migration and invasion was greatly reduced in the endostatin treated animals. Endostatin is non-toxic and does not induce aquired drug resistance and has therefor become a potent new therapy strategy in solid neoplasias. This therapy appears to have a high potential not only for the treatment of gliomas, the most common brain tumors, but also in other tumors. The ability of endostatin to inhibit neoangiogenesis is mediated, at least in part, by Zn^+2 binding and elastase processing. Widespread endostatin expression was found in elactic fibers in vessel walls and in some other basement membrane zones. Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: antiangiogenic agent; Collagen alpha-1(XVIII) chain; collagen, type XVIII, alpha 1; endostatin; FLJ27325; FLJ34914; MGC74745; multi-functional protein MFP

          View more View less

          Gene Aliases: COL18A1; KNO; KNO1; KS

          View more View less

          UniProt ID: (Human) P39060

          View more View less

          Entrez Gene ID: (Human) 80781

          View more View less

          It has to be done as per old AB suggested Products section.
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