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Invitrogen
Human FAIM3 Synthetic Peptide
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Product Details
PEP-0403
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 13 amino acids near the carboxy terminus of human Toso.
PEP-0403 can be used as a blocking peptide with polyclonal antibody PA5-20285.
Target Information
Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FAIM3; Fas apoptotic inhibitory molecule 3; Fc fragment of IgM receptor; IgM Fc fragment receptor; IgM Fc receptor; IgM FcR; Immunoglobulin mu Fc receptor; Regulator of Fas-induced apoptosis Toso; transmembrane protein; Ig superfamily member; unnamed protein product
Gene Aliases: FAIM3; FCMR; FcmuR; IgM FcR; TOSO
UniProt ID: (Human) O60667
Entrez Gene ID: (Human) 9214
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