Product References
Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.
British journal of haematology
Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y
300-19 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.
Sat Jul 01 00:00:00 EDT 2023
Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B.
The Journal of clinical investigation
Azad P,Zhou D,Tu HC,Villafuerte FC,Traver D,Rana TM,Haddad GG
300-19 was used in In vitro experiments to conclude that HIKER regulates erythropoiesis in Monge's disease and acts through at least one specific target, CSNK2B, a casein kinase.
Thu Jun 01 00:00:00 EDT 2023
Disease-associated mutations in topoisomerase IIβ result in defective NK cells.
The Journal of allergy and clinical immunology
Broderick L,Clay GM,Blum RH,Liu Y,McVicar R,Papes F,Booshehri LM,Cowell IG,Austin CA,Putnam CD,Kaufman DS
300-19 was used in Cell Culture to support that Hoffman syndrome-associated mutations in TOP2B impact NK-cell development and function in murine and human models.
Wed Jun 01 00:00:00 EDT 2022
A comparison of DNA repair pathways to achieve a site-specific gene modification of the Bruton's tyrosine kinase gene.
Molecular therapy. Nucleic acids
Gray DH,Santos J,Keir AG,Villegas I,Maddock S,Trope EC,Long JD,Kuo CY
300-19 was used in Cell Culture to compare three methods of targeted insertion — homology-directed repair (HDR), homology-independent targeted integration (HITI), and precise integration into target chromosome (PITCh) — to achieve a permanent gene-therapy-based cure for X-linked agammaglobulinemia.
Tue Mar 08 00:00:00 EST 2022
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.
EMBO reports
Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB
300-19 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.
Thu Feb 03 00:00:00 EST 2022
Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models.
Frontiers in oncology
Canals Hernaez D,Hughes MR,Li Y,Mainero Rocca I,Dean P,Brassard J,Bell EM,Samudio I,Mes-Masson AM,Narimatsu Y,Clausen H,Blixt O,Roskelley CD,McNagny KM
300-19 was used in Sample Preparation (FC/FACS) to use an array of glycosylation defective cell lines to define the PODO447 reactive epitope and reveal it as an O-linked core 1 glycan presented in the context of the Podxl peptide backbone.
Sat Jul 16 00:00:00 EDT 2022
A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.
RNA (New York, N.Y.)
Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF
300-19 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.
Thu Sep 01 00:00:00 EDT 2022
Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment.
Cell reports
Papadas A,Deb G,Cicala A,Officer A,Hope C,Pagenkopf A,Flietner E,Morrow ZT,Emmerich P,Wiesner J,Arauz G,Bansal V,Esbona K,Capitini CM,Matkowskyj KA,Deming DA,Politi K,Abrams SI,Harismendy O,Asimakopoulos F
300-19 was used in In vitro experiments to conclude that peritumoral stroma mimicking embryonic provisional matrix remodeling regulates cDC1 abundance and activity to elicit T cell-inflamed tumor microenvironments.
Tue Aug 16 00:00:00 EDT 2022
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters.
iScience
van Gils N,Verhagen HJMP,Broux M,Martiáñez T,Denkers F,Vermue E,Rutten A,Csikós T,Demeyer S,Çil M,Al M,Cools J,Janssen JJWM,Ossenkoppele GJ,Menezes RX,Smit L
300-19 was used in Cell Culture to reveal plasticity of anthracycline resistance in AML cells and highlight the potential of transcriptional reprogramming by epigenetic-based therapeutics to target chemotherapy-resistant AML cells.
Fri Sep 16 00:00:00 EDT 2022
ZNF410 represses fetal globin by singular control of CHD4.
Nature genetics
Vinjamur DS,Yao Q,Cole MA,McGuckin C,Ren C,Zeng J,Hossain M,Luk K,Wolfe SA,Pinello L,Bauer DE
300-19 was used in Cell Culture to identify zinc-finger protein (ZNF) 410 as an fetal hemoglobin repressor.
Sat May 01 00:00:00 EDT 2021
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Cancer cell
Cheng Y,Xie W,Pickering BF,Chu KL,Savino AM,Yang X,Luo H,Nguyen DT,Mo S,Barin E,Velleca A,Rohwetter TM,Patel DJ,Jaffrey SR,Kharas MG
300-19 was used in In vitro experiments to investigate How N6-Methyladenosine dictates its diverse molecular and cellular effects in leukemias.
Mon Jul 12 00:00:00 EDT 2021
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.
Cancer discovery
Montefiori LE,Bendig S,Gu Z,Chen X,Pölönen P,Ma X,Murison A,Zeng A,Garcia-Prat L,Dickerson K,Iacobucci I,Abdelhamed S,Hiltenbrand R,Mead PE,Mehr CM,Xu B,Cheng Z,Chang TC,Westover T,Ma J,Stengel A,Kimura S,Qu C,Valentine MB,Rashkovan M,Luger S,Litzow MR,Rowe JM,den Boer ML,Wang V,Yin J,Kornblau SM,Hunger SP,Loh ML,Pui CH,Yang W,Crews KR,Roberts KG,Yang JJ,Relling MV,Evans WE,Stock W,Paietta EM,Ferrando AA,Zhang J,Kern W,Haferlach T,Wu G,Dick JE,Klco JM,Haferlach C,Mullighan CG
300-19 was used in In vitro experiments to identify oncogenic deregulation of BCL11B driven by diverse structural alterations, including de novo superenhancer generation, as the driving feature of a subset of lineage-ambiguous leukemias that transcend current diagnostic boundaries.
Mon Nov 01 00:00:00 EDT 2021
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.
Cell stem cell
Kruta M,Sunshine MJ,Chua BA,Fu Y,Chawla A,Dillingham CH,Hidalgo San Jose L,De Jong B,Zhou FJ,Signer RAJ
Thu Nov 04 00:00:00 EDT 2021
MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia.
Cell stem cell
Rodríguez A,Zhang K,Färkkilä A,Filiatrault J,Yang C,Velázquez M,Furutani E,Goldman DC,García de Teresa B,Garza-Mayén G,McQueen K,Sambel LA,Molina B,Torres L,González M,Vadillo E,Pelayo R,Fleming WH,Grompe M,Shimamura A,Hautaniemi S,Greenberger J,Frías S,Parmar K,D'Andrea AD
300-19 was used in In vitro experiments to identify determinants of bone marrow failure, we performed single-cell transcriptome profiling of primary hematopoietic stem and progenitor cells from Fanconi anemia patients.
Thu Jan 07 00:00:00 EST 2021
Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.
Cell stem cell
Van Egeren D,Escabi J,Nguyen M,Liu S,Reilly CR,Patel S,Kamaz B,Kalyva M,DeAngelo DJ,Galinsky I,Wadleigh M,Winer ES,Luskin MR,Stone RM,Garcia JS,Hobbs GS,Camargo FD,Michor F,Mullally A,Cortes-Ciriano I,Hormoz S
Thu Mar 04 00:00:00 EST 2021
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing.
Cell stem cell
Rao S,Yao Y,Soares de Brito J,Yao Q,Shen AH,Watkinson RE,Kennedy AL,Coyne S,Ren C,Zeng J,Serbin AV,Studer S,Ballotti K,Harris CE,Luk K,Stevens CS,Armant M,Pinello L,Wolfe SA,Chiarle R,Shimamura A,Lee B,Newburger PE,Bauer DE
Thu May 06 00:00:00 EDT 2021
A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors.
Cellular & molecular immunology
Moirangthem RD,Ma K,Lizot S,Cordesse A,Olivré J,de Chappedelaine C,Joshi A,Cieslak A,Tchen J,Cagnard N,Asnafi V,Rausell A,Simons L,Zuber J,Taghon T,Staal FJT,Pflumio F,Six E,Cavazzana M,Lagresle-Peyrou C,Soheili T,André I
Thu Jul 01 00:00:00 EDT 2021
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Molecular cell
Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM
300-19 was used in In vitro experiments to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.
Thu Jul 01 00:00:00 EDT 2021
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.
Science translational medicine
Reyes M,Filbin MR,Bhattacharyya RP,Sonny A,Mehta A,Billman K,Kays KR,Pinilla-Vera M,Benson ME,Cosimi LA,Hung DT,Levy BD,Villani AC,Sade-Feldman M,Baron RM,Goldberg MB,Blainey PC,Hacohen N
Wed Jun 16 00:00:00 EDT 2021
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
The Journal of experimental medicine
Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ
Mon Feb 01 00:00:00 EST 2021
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.
The Journal of experimental medicine
Le Coz C,Nguyen DN,Su C,Nolan BE,Albrecht AV,Xhani S,Sun D,Demaree B,Pillarisetti P,Khanna C,Wright F,Chen PA,Yoon S,Stiegler AL,Maurer K,Garifallou JP,Rymaszewski A,Kroft SH,Olson TS,Seif AE,Wertheim G,Grant SFA,Vo LT,Puck JM,Sullivan KE,Routes JM,Zakharova V,Shcherbina A,Mukhina A,Rudy NL,Hurst ACE,Atkinson TP,Boggon TJ,Hakonarson H,Abate AR,Hajjar J,Nicholas SK,Lupski JR,Verbsky J,Chinn IK,Gonzalez MV,Wells AD,Marson A,Poon GMK,Romberg N
Mon Jul 05 00:00:00 EDT 2021
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
EMBO molecular medicine
Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P
Fri Mar 05 00:00:00 EST 2021
Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.
Leukemia
Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM
Mon Nov 01 00:00:00 EDT 2021
Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling.
Molecular therapy. Nucleic acids
Kazuki Y,Uno N,Abe S,Kajitani N,Kazuki K,Yakura Y,Sawada C,Takata S,Sugawara M,Nagashima Y,Okada A,Hiratsuka M,Osaki M,Ferrari G,Tedesco FS,Nishikawa S,Fukumoto K,Takayanagi SI,Kunisato A,Kaneko S,Oshimura M,Tomizuka K
Fri Mar 05 00:00:00 EST 2021
Reducing TGF-β1 cooperated with StemRegenin 1 promoted the expansion ex vivo of cord blood CD34+ cells by inhibiting AhR signalling.
Cell proliferation
Zhu X,Sun Q,Tan WS,Cai H
Mon Mar 01 00:00:00 EST 2021
Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.
Stem cells translational medicine
Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H
Tue Jun 01 00:00:00 EDT 2021
Enhanced self-renewal of human long-term hematopoietic stem cells by a sulfamoyl benzoate derivative targeting p18INK4C.
Blood advances
Li Y,Zhang W,Zhang Y,Ding Y,Yang M,He M,Liu X,Gu J,Xu S,Feng Z,Li Y,Yin J,Gao H,Song H,Xu H,Wang C,Ji Q,Ma S,Yang W,Yuan W,Xie XQ,Cheng T,Gao Y
Tue Sep 14 00:00:00 EDT 2021
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency.
Blood advances
Zoccolillo M,Brigida I,Barzaghi F,Scala S,Hernández RJ,Basso-Ricci L,Colantuoni M,Pettinato E,Sergi LS,Milardi G,Capasso P,Lombardo A,Gregori S,Sanvito F,Schena F,Cesaro S,Conti F,Pession A,Benedetti F,Gattorno M,Lee PY,Naldini L,Cicalese MP,Aiuti A,Mortellaro A
Tue Aug 24 00:00:00 EDT 2021
CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.
Stem cells (Dayton, Ohio)
Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM
Sat May 01 00:00:00 EDT 2021
CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.
Stem cells (Dayton, Ohio)
Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM
Sat May 01 00:00:00 EDT 2021
HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.
Stem cells international
Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS
Tue Jun 08 00:00:00 EDT 2021
Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.
Transfusion
Cunningham S,Hackstein H
Tue Jun 01 00:00:00 EDT 2021
Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome.
Nature communications
Kennedy AL,Myers KC,Bowman J,Gibson CJ,Camarda ND,Furutani E,Muscato GM,Klein RH,Ballotti K,Liu S,Harris CE,Galvin A,Malsch M,Dale D,Gansner JM,Nakano TA,Bertuch A,Vlachos A,Lipton JM,Castillo P,Connelly J,Churpek J,Edwards JR,Hijiya N,Ho RH,Hofmann I,Huang JN,Keel S,Lamble A,Lau BW,Norkin M,Stieglitz E,Stock W,Walkovich K,Boettcher S,Brendel C,Fleming MD,Davies SM,Weller EA,Bahl C,Carter SL,Shimamura A,Lindsley RC
Fri Feb 26 00:00:00 EST 2021
Stem-cell-derived human microglia transplanted into mouse brain to study human disease.
Nature protocols
Fattorelli N,Martinez-Muriana A,Wolfs L,Geric I,De Strooper B,Mancuso R
300-19 was used in Sample Preparation to explain the step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment. This approach is more optimized and more efficient approach that yields up to 80% chimerism when compared to current differentiation and xenotransplantation protocols.
Mon Feb 01 00:00:00 EST 2021
Multi-scale Dynamical Modeling of T Cell Development from an Early Thymic Progenitor State to Lineage Commitment.
Cell reports
Olariu V,Yui MA,Krupinski P,Zhou W,Deichmann J,Andersson E,Rothenberg EV,Peterson C
Tue Jan 12 00:00:00 EST 2021
Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice.
Communications biology
Barcia Durán JG,Lu T,Houghton S,Geng F,Schreiner R,Xiang J,Rafii S,Redmond D,Lis R
Thu Mar 25 00:00:00 EDT 2021
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis.
Nature communications
Biavasco R,Lettera E,Giannetti K,Gilioli D,Beretta S,Conti A,Scala S,Cesana D,Gallina P,Norelli M,Basso-Ricci L,Bondanza A,Cavalli G,Ponzoni M,Dagna L,Doglioni C,Aiuti A,Merelli I,Di Micco R,Montini E
Tue Jul 27 00:00:00 EDT 2021
The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling.
Cell reports
Zyulina V,Yan KK,Ju B,Schwarzenberger E,Passegger C,Tam-Amersdorfer C,Pan Q,Sconocchia T,Pollack C,Shaner B,Zebisch A,Easton J,Yu J,Silva JM,Strobl H
Tue Apr 27 00:00:00 EDT 2021
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases.
Science advances
Trapecar M,Wogram E,Svoboda D,Communal C,Omer A,Lungjangwa T,Sphabmixay P,Velazquez J,Schneider K,Wright CW,Mildrum S,Hendricks A,Levine S,Muffat J,Lee MJ,Lauffenburger DA,Trumper D,Jaenisch R,Griffith LG
300-19 was used in In vitro experiments to develop a mesofluidic platform technology to study gut-liver-cerebral interactions in the context of Parkinson's disease (PD).
Fri Jan 01 00:00:00 EST 2021
Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.
iScience
Zee BM,Poels KE,Yao CH,Kawabata KC,Wu G,Duy C,Jacobus WD,Senior E,Endress JE,Jambhekar A,Lovitch SB,Ma J,Dhall A,Harris IS,Blanco MA,Sykes DB,Licht JD,Weinstock DM,Melnick A,Haigis MC,Michor F,Shi Y
Fri Jun 25 00:00:00 EDT 2021
Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses.
Cell reports
Yu K,Hammerschmidt SI,Permanyer M,Galla M,Rothe M,Zheng X,Werth K,Martens R,Lueder Y,Janssen A,Friedrichsen M,Bernhardt G,Förster R
Tue Jun 22 00:00:00 EDT 2021
Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy.
eLife
Simkin D,Marshall KA,Vanoye CG,Desai RR,Bustos BI,Piyevsky BN,Ortega JA,Forrest M,Robertson GL,Penzes P,Laux LC,Lubbe SJ,Millichap JJ,George AL,Kiskinis E
300-19 was used in Cell Culture to measure the functional properties of differentiated excitatory neurons in an induced pluripotent stem cell (iPSCs) and gene editing established disease model.
Fri Feb 05 00:00:00 EST 2021
Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays.
STAR protocols
Rodríguez A,Filiatrault J,Flores-Guzmán P,Mayani H,Parmar K,D'Andrea AD
300-19 was used in Cell Culture to present protocols for the isolation of human and murine HSPCs using manual and FACS-assisted techniques.
Fri Dec 17 00:00:00 EST 2021
Directly reprogrammed natural killer cells for cancer immunotherapy.
Nature biomedical engineering
Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS
Mon Nov 01 00:00:00 EDT 2021
The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.
Communications biology
Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S
Mon Jun 07 00:00:00 EDT 2021
NOTCH-mediated ex vivo expansion of human hematopoietic stem and progenitor cells by culture under hypoxia.
Stem cell reports
Araki D,Fu JF,Huntsman H,Cordes S,Seifuddin F,Alvarado LJ,Cheruku PS,Cash A,Traba J,Li Y,Pirooznia M,Smith RH,Larochelle A
Tue Sep 14 00:00:00 EDT 2021
Molecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds.
Scientific reports
Marx-Blümel L,Marx C,Sonnemann J,Weise F,Hampl J,Frey J,Rothenburger L,Cirri E,Rahnis N,Koch P,Groth M,Schober A,Wang ZQ,Beck JF
Wed Oct 27 00:00:00 EDT 2021
Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Cell reports
Su H,Jiang M,Senevirathne C,Aluri S,Zhang T,Guo H,Xavier-Ferrucio J,Jin S,Tran NT,Liu SM,Sun CW,Zhu Y,Zhao Q,Chen Y,Cable L,Shen Y,Liu J,Qu CK,Han X,Klug CA,Bhatia R,Chen Y,Nimer SD,Zheng YG,Iancu-Rubin C,Jin J,Deng H,Krause DS,Xiang J,Verma A,Luo M,Zhao X
Tue Jul 27 00:00:00 EDT 2021
Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia.
Nature communications
Goldfarb AN,Freeman KC,Sahu RK,Elagib KE,Holy M,Arneja A,Polanowska-Grabowska R,Gru AA,White Z,Khalil S,Kerins MJ,Ooi A,Leitinger N,Luckey CJ,Delehanty LL
Fri Mar 12 00:00:00 EST 2021
CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells.
Nature communications
Boutin J,Rosier J,Cappellen D,Prat F,Toutain J,Pennamen P,Bouron J,Rooryck C,Merlio JP,Lamrissi-Garcia I,Cullot G,Amintas S,Guyonnet-Duperat V,Ged C,Blouin JM,Richard E,Dabernat S,Moreau-Gaudry F,Bedel A
Fri Aug 13 00:00:00 EDT 2021
In vitro expansion of fetal liver hematopoietic stem cells.
Scientific reports
Bhardwaj R,Kumar L,Chhabra D,Mehra NK,Sharma A,Mohanty S,Kochupillai V
Fri Jun 04 00:00:00 EDT 2021
Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.
Scientific reports
Stahlhut M,Ha TC,Takmakova E,Morgan MA,Schwarzer A,Schaudien D,Eder M,Schambach A,Kustikova OS
Fri Mar 05 00:00:00 EST 2021
SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.
Cell reports
Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II
300-19 was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.
Tue Feb 16 00:00:00 EST 2021
CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data.
Nature communications
Amit I,Iancu O,Levy-Jurgenson A,Kurgan G,McNeill MS,Rettig GR,Allen D,Breier D,Ben Haim N,Wang Y,Anavy L,Hendel A,Yakhini Z
Mon May 24 00:00:00 EDT 2021
Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.
Cell reports. Medicine
Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L
300-19 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.
Tue Nov 16 00:00:00 EST 2021
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.
Nature communications
Sharma R,Dever DP,Lee CM,Azizi A,Pan Y,Camarena J,Köhnke T,Bao G,Porteus MH,Majeti R
Wed Jan 20 00:00:00 EST 2021
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Nature communications
Velten L,Story BA,Hernández-Malmierca P,Raffel S,Leonce DR,Milbank J,Paulsen M,Demir A,Szu-Tu C,Frömel R,Lutz C,Nowak D,Jann JC,Pabst C,Boch T,Hofmann WK,Müller-Tidow C,Trumpp A,Haas S,Steinmetz LM
Mon Mar 01 00:00:00 EST 2021
Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect.
Stem cell research & therapy
Chruewkamlow N,Pruekprasert K,Phutthakunphithak P,Acharayothin O,Prapassaro T,Hongku K,Hahtapornsawan S,Puangpunngam N,Chinsakchai K,Wongwanit C,Ruangsetakit C,Sermsathanasawadi N
300-19 was used in Cell Culture to evaluate the use of Quality and Quantity culture media to culture mononuclear cells from chronic limb-threatening ischemia patients.
Tue Sep 28 00:00:00 EDT 2021
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.
Nature communications
Rice S,Jackson T,Crump NT,Fordham N,Elliott N,O'Byrne S,Fanego MDML,Addy D,Crabb T,Dryden C,Inglott S,Ladon D,Wright G,Bartram J,Ancliff P,Mead AJ,Halsey C,Roberts I,Milne TA,Roy A
Thu Nov 25 00:00:00 EST 2021
Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells.
Cell death & disease
Malyukova A,Ujvari D,Yektaei-Karin E,Zovko A,Madapura HS,Keszei M,Nagy N,Lotfi K,Björn N,Wallvik J,Tamai M,Nguyen TTT,Akahane K,Inukai T,Stenke L,Salamon D
Sat Sep 25 00:00:00 EDT 2021
Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector.
Molecular therapy. Methods & clinical development
Seymour BJ,Singh S,Certo HM,Sommer K,Sather BD,Khim S,Clough C,Hale M,Pangallo J,Ryu BY,Khan IF,Adair JE,Rawlings DJ
Fri Mar 12 00:00:00 EST 2021
Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia.
Scientific reports
Hofmans M,Lammens T,Depreter B,Wu Y,Erlacher M,Caye A,Cavé H,Flotho C,de Haas V,Niemeyer CM,Stary J,Van Nieuwerburgh F,Deforce D,Van Loocke W,Van Vlierberghe P,Philippé J,De Moerloose B
Tue Feb 02 00:00:00 EST 2021
Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms.
Cell stem cell
Tong J,Sun T,Ma S,Zhao Y,Ju M,Gao Y,Zhu P,Tan P,Fu R,Zhang A,Wang D,Wang D,Xiao Z,Zhou J,Yang R,Loughran SJ,Li J,Green AR,Bresnick EH,Wang D,Cheng T,Zhang L,Shi L
Thu Mar 04 00:00:00 EST 2021
The Use of Induced Pluripotent Stem Cells to Study the Effects of Adenosine Deaminase Deficiency on Human Neutrophil Development.
Frontiers in immunology
Tsui M,Min W,Ng S,Dobbs K,Notarangelo LD,Dror Y,Grunebaum E
300-19 was used in Cell Culture to study the characterization of neutrophil developmental abnormalities and the mechanisms contributing to them to demonstrate the important role of adenosine deaminase (ADA) in the development and function of neutrophils while clarifying the mechanisms responsible for the neutrophil abnormalities in ADA-deficient patients.
Mon Dec 27 00:00:00 EST 2021
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.
Nature
Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP
Tue Sep 01 00:00:00 EDT 2020
Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development.
Immunity
Le J,Park JE,Ha VL,Luong A,Branciamore S,Rodin AS,Gogoshin G,Li F,Loh YE,Camacho V,Patel SB,Welner RS,Parekh C
Tue Jun 16 00:00:00 EDT 2020
Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.
Nature genetics
Lin KH,Rutter JC,Xie A,Pardieu B,Winn ET,Bello RD,Forget A,Itzykson R,Ahn YR,Dai Z,Sobhan RT,Anderson GR,Singleton KR,Decker AE,Winter PS,Locasale JW,Crawford L,Puissant A,Wood KC
300-19 was used in Cell Culture to perform pooled CRISPR-Cas9 knockout screens in acute myeloid leukemia (AML) cells treated with various chemotherapies to map the drug-dependent genetic basis of fitness trade-offs, a concept known as antagonistic pleiotropy (AP).
Wed Apr 01 00:00:00 EDT 2020
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
300-19 was used in Cell Culture to demonstrate if fat mass and obesity-associated protein plays critical roles in cancer stem cell self-renewal and immune evasion.
Mon Jul 13 00:00:00 EDT 2020
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
300-19 was used in Cell Culture to demonstrate if fat mass and obesity-associated protein plays critical roles in cancer stem cell self-renewal and immune evasion.
Mon Jul 13 00:00:00 EDT 2020
The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.
Cancer discovery
Su A,Ling F,Vaganay C,Sodaro G,Benaksas C,Dal Bello R,Forget A,Pardieu B,Lin KH,Rutter JC,Bassil CF,Fortin G,Pasanisi J,Antony-Debré I,Alexe G,Benoist JF,Pruvost A,Pikman Y,Qi J,Schlageter MH,Micol JB,Roti G,Cluzeau T,Dombret H,Preudhomme C,Fenouille N,Benajiba L,Golan HM,Stegmaier K,Lobry C,Wood KC,Itzykson R,Puissant A
300-19 was used in Cell Culture to investigate the effects of MTHFR for its therapeutic effects on acute myeloid leukemia.
Tue Dec 01 00:00:00 EST 2020
Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo.
Blood
Tarumoto Y,Lin S,Wang J,Milazzo JP,Xu Y,Lu B,Yang Z,Wei Y,Polyanskaya S,Wunderlich M,Gray NS,Stegmaier K,Vakoc CR
Thu Jan 02 00:00:00 EST 2020
Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171.
Blood
Subramaniam A,Žemaitis K,Talkhoncheh MS,Yudovich D,Bäckström A,Debnath S,Chen J,Jain MV,Galeev R,Gaetani M,Zubarev RA,Larsson J
Thu Nov 05 00:00:00 EST 2020
Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia.
Blood
Gebru MT,Atkinson JM,Young MM,Zhang L,Tang Z,Liu Z,Lu P,Dower CM,Chen L,Annageldiyev C,Sharma A,Imamura Kawasawa Y,Zhao Z,Miller BA,Claxton DF,Wang HG
Thu Aug 27 00:00:00 EDT 2020
Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency.
Blood
Grey W,Chauhan R,Piganeau M,Huerga Encabo H,Garcia-Albornoz M,McDonald NQ,Bonnet D
Thu Nov 26 00:00:00 EST 2020
Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.
Blood
Xiao Y,van Halteren AGS,Lei X,Borst J,Steenwijk E,de Wit T,Grabowska J,Voogd R,Kemps P,Picarsic J,van den Bos C,Borst J
Thu Nov 05 00:00:00 EST 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
300-19 was used in Cell Culture to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.
Cell stem cell
Jones CL,Stevens BM,Pollyea DA,Culp-Hill R,Reisz JA,Nemkov T,Gehrke S,Gamboni F,Krug A,Winters A,Pei S,Gustafson A,Ye H,Inguva A,Amaya M,Minhajuddin M,Abbott D,Becker MW,DeGregori J,Smith CA,D'Alessandro A,Jordan CT
300-19 was used in Tissue/organ culture to demonstrate that elevated nicotinamide metabolism is both the mechanistic basis for ven/aza resistance and a metabolic vulnerability of R/R LSCs.
Thu Nov 05 00:00:00 EST 2020
Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells.
Cell stem cell
Nagpal N,Wang J,Zeng J,Lo E,Moon DH,Luk K,Braun RO,Burroughs LM,Keel SB,Reilly C,Lindsley RC,Wolfe SA,Tai AK,Cahan P,Bauer DE,Fong YW,Agarwal S
300-19 was used in Cell Culture to describe small-molecule PAPD5 inhibitors that demonstrate telomere restoration in vitro, in stem cell models, and in vivo.
Thu Jun 04 00:00:00 EDT 2020
C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation.
The Journal of clinical investigation
N'diaye M,Brauner S,Flytzani S,Kular L,Warnecke A,Adzemovic MZ,Piket E,Min JH,Edwards W,Mela F,Choi HY,Magg V,James T,Linden M,Reichardt HM,Daws MR,van Horssen J,Kockum I,Harris RA,Olsson T,Guerreiro-Cacais AO,Jagodic M
Mon Feb 03 00:00:00 EST 2020
Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis.
The Journal of experimental medicine
Xiong Z,Xia P,Zhu X,Geng J,Wang S,Ye B,Qin X,Qu Y,He L,Fan D,Du Y,Tian Y,Fan Z
Mon Feb 03 00:00:00 EST 2020
Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9.
The Journal of experimental medicine
Freund EC,Lock JY,Oh J,Maculins T,Delamarre L,Bohlen CJ,Haley B,Murthy A
Mon Jul 06 00:00:00 EDT 2020
Real-Time NMR Spectroscopy for Studying Metabolism.
Angewandte Chemie (International ed. in English)
Alshamleh I,Krause N,Richter C,Kurrle N,Serve H,Günther UL,Schwalbe H
Mon Feb 03 00:00:00 EST 2020
Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production.
Developmental cell
Frame JM,Kubaczka C,Long TL,Esain V,Soto RA,Hachimi M,Jing R,Shwartz A,Goessling W,Daley GQ,North TE
300-19 was used in In vitro experiments to establish the inflammasome as a conserved metabolic sensor that expands HSPC production in vivo and in vitro.
Mon Oct 26 00:00:00 EDT 2020
Efficient and nontoxic biomolecule delivery to primary human hematopoietic stem cells using nanostraws.
Proceedings of the National Academy of Sciences of the United States of America
Schmiderer L,Subramaniam A,Žemaitis K,Bäckström A,Yudovich D,Soboleva S,Galeev R,Prinz CN,Larsson J,Hjort M
Tue Sep 01 00:00:00 EDT 2020
Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America
Belling JN,Heidenreich LK,Tian Z,Mendoza AM,Chiou TT,Gong Y,Chen NY,Young TD,Wattanatorn N,Park JH,Scarabelli L,Chiang N,Takahashi J,Young SG,Stieg AZ,De Oliveira S,Huang TJ,Weiss PS,Jonas SJ
Tue May 19 00:00:00 EDT 2020
Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.
Proceedings of the National Academy of Sciences of the United States of America
Qiao X,van der Zanden SY,Wander DPA,Borràs DM,Song JY,Li X,van Duikeren S,van Gils N,Rutten A,van Herwaarden T,van Tellingen O,Giacomelli E,Bellin M,Orlova V,Tertoolen LGJ,Gerhardt S,Akkermans JJ,Bakker JM,Zuur CL,Pang B,Smits AM,Mummery CL,Smit L,Arens R,Li J,Overkleeft HS,Neefjes J
Tue Jun 30 00:00:00 EDT 2020
Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.
Proceedings of the National Academy of Sciences of the United States of America
Wang T,Medynets M,Johnson KR,Doucet-O'Hare TT,DiSanza B,Li W,Xu Y,Bagnell A,Tyagi R,Sampson K,Malik N,Steiner J,Hadegan A,Kowalak J,O'Malley J,Maric D,Nath A
Tue Jul 28 00:00:00 EDT 2020
ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells.
Oncogene
Redondo Monte E,Wilding A,Leubolt G,Kerbs P,Bagnoli JW,Hartmann L,Hiddemann W,Chen-Wichmann L,Krebs S,Blum H,Cusan M,Vick B,Jeremias I,Enard W,Theurich S,Wichmann C,Greif PA
Wed Apr 01 00:00:00 EDT 2020
Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34+ cells via inhibition of senescence.
Stem cells translational medicine
Li X,Ma X,Chen Y,Peng D,Wang H,Chen S,Xiao Y,Li L,Zhou H,Cheng F,Gao Y,Chang J,Cheng T,Liu L
Tue Dec 01 00:00:00 EST 2020
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response.
Oncogenesis
Giuli MV,Diluvio G,Giuliani E,Franciosa G,Di Magno L,Pignataro MG,Tottone L,Nicoletti C,Besharat ZM,Peruzzi G,Pelullo M,Palermo R,Canettieri G,Talora C,d'Amati G,Bellavia D,Screpanti I,Checquolo S
Sun Oct 18 00:00:00 EDT 2020
EDAG mediates Hsp70 nuclear localization in erythroblasts and rescues dyserythropoiesis in myelodysplastic syndrome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dong XM,Zhao K,Zheng WW,Xu CW,Zhang MJ,Yin RH,Gao R,Tang LJ,Liu JF,Chen H,Zhan YQ,Yu M,Ge CH,Gao HY,Li X,Luo T,Ning HM,Yang XM,Li CY
Mon Jun 01 00:00:00 EDT 2020
Targeted gene correction of human hematopoietic stem cells for the treatment of Wiskott - Aldrich Syndrome.
Nature communications
Rai R,Romito M,Rivers E,Turchiano G,Blattner G,Vetharoy W,Ladon D,Andrieux G,Zhang F,Zinicola M,Leon-Rico D,Santilli G,Thrasher AJ,Cavazza A
Wed Aug 12 00:00:00 EDT 2020
Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
Nature communications
Leonards K,Almosailleakh M,Tauchmann S,Bagger FO,Thirant C,Juge S,Bock T,Méreau H,Bezerra MF,Tzankov A,Ivanek R,Losson R,Peters AHFM,Mercher T,Schwaller J
Fri Jun 12 00:00:00 EDT 2020
Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation.
Communications biology
Yao Y,Yang J,Qin Q,Tang C,Li Z,Chen L,Li K,Ren C,Chen L,Rao S
Fri Dec 18 00:00:00 EST 2020
Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential.
Stem cell reports
Lange L,Hoffmann D,Schwarzer A,Ha TC,Philipp F,Lenz D,Morgan M,Schambach A
Tue Jan 14 00:00:00 EST 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
300-19 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 EST 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
300-19 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 EST 2020
iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests.
Stem cell reports
Themeli M,Chhatta A,Boersma H,Prins HJ,Cordes M,de Wilt E,Farahani AS,Vandekerckhove B,van der Burg M,Hoeben RC,Staal FJT,Mikkers HMM
Tue Feb 11 00:00:00 EST 2020
Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling.
Cell reports
Sinha S,Biswas M,Chatterjee SS,Kumar S,Sengupta A
300-19 was used in Cell Culture to study the molecular integration of developmental signaling with mesenchymal-stromal-cell (MSC) intrinsic chromatin regulation. To reveal a link illustrating epi-genomic feedforward control of bone morphogenic protein (BMP)/transforming growth factor β (TGF-β) signaling to transcriptional and cellular plasticity in the mesenchymal microenvironment and account for stromal-SWI/SNF in hematopoiesis.
Tue Apr 28 00:00:00 EDT 2020
Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia.
STAR protocols
Ryan SK,Jordan-Sciutto KL,Anderson SA
Fri Dec 18 00:00:00 EST 2020
DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.
Cell death & disease
Johnson DC,Okondo MC,Orth EL,Rao SD,Huang HC,Ball DP,Bachovchin DA
Fri Aug 14 00:00:00 EDT 2020
Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells.
Clinical & translational immunology
Pearson FE,Tullett KM,Leal-Rojas IM,Haigh OL,Masterman KA,Walpole C,Bridgeman JS,McLaren JE,Ladell K,Miners K,Llewellyn-Lacey S,Price DA,Tunger A,Schmitz M,Miles JJ,Lahoud MH,Radford KJ
Fri Apr 15 00:00:00 EDT 2022
Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype.
Nature communications
Thornton N,Karamatic Crew V,Tilley L,Green CA,Tay CL,Griffiths RE,Singleton BK,Spring F,Walser P,Alattar AG,Jones B,Laundy R,Storry JR,Möller M,Wall L,Charlewood R,Westhoff CM,Lomas-Francis C,Yahalom V,Feick U,Seltsam A,Mayer B,Olsson ML,Anstee DJ
Thu Jul 16 00:00:00 EDT 2020
Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.
Bio-protocol
Chen IP
300-19 was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.
Sun Dec 20 00:00:00 EST 2020
Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System.
Molecular therapy. Methods & clinical development
Shapiro J,Iancu O,Jacobi AM,McNeill MS,Turk R,Rettig GR,Amit I,Tovin-Recht A,Yakhini Z,Behlke MA,Hendel A
Fri Jun 12 00:00:00 EDT 2020
Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.
Nature communications
Araki R,Hoki Y,Suga T,Obara C,Sunayama M,Imadome K,Fujita M,Kamimura S,Nakamura M,Wakayama S,Nagy A,Wakayama T,Abe M
Fri Jan 10 00:00:00 EST 2020
Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway.
Cells
Haake K,Neehus AL,Buchegger T,Kühnel MP,Blank P,Philipp F,Oleaga-Quintas C,Schulz A,Grimley M,Goethe R,Jonigk D,Kalinke U,Boisson-Dupuis S,Casanova JL,Bustamante J,Lachmann N
300-19 was used in In vitro experiments to report a disease modeling platform to study the role of macrophages in patients with inborn errors of IFN-γ immunity.
Wed Feb 19 00:00:00 EST 2020
Establishment of a Long-Term Co-culture Assay for Mesenchymal Stromal Cells and Hematopoietic Stem/Progenitors.
STAR protocols
Sinha S,Chakraborty S,Sengupta A
Fri Dec 18 00:00:00 EST 2020
Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.
Immunity
Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H
Tue Nov 19 00:00:00 EST 2019
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer cell
Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG
300-19 was used in Cell Culture to show that FTO is a druggable target and that targeting FTO by small-molecule inhibitors holds potential to treat AML.
Mon Apr 15 00:00:00 EDT 2019
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer cell
Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG
300-19 was used in Cell Culture to show that FTO is a druggable target and that targeting FTO by small-molecule inhibitors holds potential to treat AML.
Mon Apr 15 00:00:00 EDT 2019
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Cancer cell
Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH
Mon Aug 12 00:00:00 EDT 2019
Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program.
Blood
Mack EA,Stein SJ,Rome KS,Xu L,Wertheim GB,Melo RCN,Pear WS
Thu May 30 00:00:00 EDT 2019
Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.
Blood
Alvarado LJ,Huntsman HD,Cheng H,Townsley DM,Winkler T,Feng X,Dunbar CE,Young NS,Larochelle A
Thu May 09 00:00:00 EDT 2019
Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes.
Blood
Hsu J,Reilly A,Hayes BJ,Clough CA,Konnick EQ,Torok-Storb B,Gulsuner S,Wu D,Becker PS,Keel SB,Abkowitz JL,Doulatov S
Thu Jul 11 00:00:00 EDT 2019
IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia.
Blood
González-García S,Mosquera M,Fuentes P,Palumbo T,Escudero A,Pérez-Martínez A,Ramírez M,Corcoran AE,Toribio ML
Thu Dec 12 00:00:00 EST 2019
Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.
Cell stem cell
Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L
300-19 was used in In vitro experiments to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.
Thu Oct 03 00:00:00 EDT 2019
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.
Science translational medicine
Sharon D,Cathelin S,Mirali S,Di Trani JM,Yanofsky DJ,Keon KA,Rubinstein JL,Schimmer AD,Ketela T,Chan SM
300-19 was used in Cell Culture to investigate if inactivation of genes involved in mitochondrial translation restores sensitivity to venetoclax in resistant acute myeloid leukemia cells.
Wed Oct 30 00:00:00 EDT 2019
Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity.
The Journal of experimental medicine
Medina BD,Liu M,Vitiello GA,Seifert AM,Zeng S,Bowler T,Zhang JQ,Cavnar MJ,Loo JK,Param NJ,Maltbaek JH,Rossi F,Balachandran V,DeMatteo RP
Mon Jun 03 00:00:00 EDT 2019
Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.
The Journal of experimental medicine
Deng M,Guo H,Tam JW,Johnson BM,Brickey WJ,New JS,Lenox A,Shi H,Golenbock DT,Koller BH,McKinnon KP,Beutler B,Ting JP
Mon Dec 02 00:00:00 EST 2019
NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia.
Leukemia
Lopez-Millan B,Sanchéz-Martínez D,Roca-Ho H,Gutiérrez-Agüera F,Molina O,Diaz de la Guardia R,Torres-Ruiz R,Fuster JL,Ballerini P,Suessbier U,Nombela-Arrieta C,Bueno C,Menéndez P
Mon Jul 01 00:00:00 EDT 2019
Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America
Wang KW,Zhan X,McAlpine W,Zhang Z,Choi JH,Shi H,Misawa T,Yue T,Zhang D,Wang Y,Ludwig S,Russell J,Tang M,Li X,Murray AR,Moresco EMY,Turer EE,Beutler B
Tue Jun 04 00:00:00 EDT 2019
Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.
Cell systems
Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV
300-19 was used in Cell Culture to imply that multilineage priming is integral to T cell specification.
Wed Oct 23 00:00:00 EDT 2019
Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1α in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and Progenitor Cells.
Antioxidants & redox signaling
Halvarsson C,Rörby E,Eliasson P,Lang S,Soneji S,Jönsson JI
300-19 was used in Cell Culture to investigate if HIF-1α protects hematopoietic stem cells against ROS.
Sat Jul 20 00:00:00 EDT 2019
Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair.
Stem cells (Dayton, Ohio)
Lomova A,Clark DN,Campo-Fernandez B,Flores-Bjurström C,Kaufman ML,Fitz-Gibbon S,Wang X,Miyahira EY,Brown D,DeWitt MA,Corn JE,Hollis RP,Romero Z,Kohn DB
Fri Feb 01 00:00:00 EST 2019
Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties.
Stem cells (Dayton, Ohio)
Abu-Khader A,Law KW,Jahan S,Manesia JK,Pasha R,Hovey O,Pineault N
Fri Mar 01 00:00:00 EST 2019
Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index.
Scientific reports
Li Y,Thomas D,Deutzmann A,Majeti R,Felsher DW,Dill DL
Thu Nov 14 00:00:00 EST 2019
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.
Nature communications
Nayak RC,Hegde S,Althoff MJ,Wellendorf AM,Mohmoud F,Perentesis J,Reina-Campos M,Reynaud D,Zheng Y,Diaz-Meco MT,Moscat J,Cancelas JA
Fri Jan 04 00:00:00 EST 2019
A comprehensive single cell transcriptional landscape of human hematopoietic progenitors.
Nature communications
Pellin D,Loperfido M,Baricordi C,Wolock SL,Montepeloso A,Weinberg OK,Biffi A,Klein AM,Biasco L
Mon Jun 03 00:00:00 EDT 2019
Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice.
Scientific reports
Radtke S,Görgens A,da Conceição Castro SV,Kordelas L,Köninger A,Dürig J,Möllmann M,Horn PA,Giebel B
Mon Sep 09 00:00:00 EDT 2019
Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.
Cell stem cell
Masiuk KE,Laborada J,Roncarolo MG,Hollis RP,Kohn DB
300-19 was used in Cell Culture to demonstrate preclinical efficacy for the treatment of IPEX patients by autologous HSC transplant and may provide valuable insights into new cell therapies for autoimmunity.
Thu Feb 07 00:00:00 EST 2019
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.
Nature communications
Kusakabe M,Sun AC,Tyshchenko K,Wong R,Nanda A,Shanna C,Gusscott S,Chavez EA,Lorzadeh A,Zhu A,Hill A,Hung S,Brown S,Babaian A,Wang X,Holt RA,Steidl C,Karsan A,Humphries RK,Eaves CJ,Hirst M,Weng AP
Tue Jul 02 00:00:00 EDT 2019
UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.
Scientific reports
Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II
Mon Apr 29 00:00:00 EDT 2019
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.
Nature communications
Papaioannou D,Petri A,Dovey OM,Terreri S,Wang E,Collins FA,Woodward LA,Walker AE,Nicolet D,Pepe F,Kumchala P,Bill M,Walker CJ,Karunasiri M,Mrózek K,Gardner ML,Camilotto V,Zitzer N,Cooper JL,Cai X,Rong-Mullins X,Kohlschmidt J,Archer KJ,Freitas MA,Zheng Y,Lee RJ,Aifantis I,Vassiliou G,Singh G,Kauppinen S,Bloomfield CD,Dorrance AM,Garzon R
Mon Nov 25 00:00:00 EST 2019
Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.
Nature communications
Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T
Fri Dec 06 00:00:00 EST 2019
Mesenchymal stem cell therapy induces FLT3L and CD1c+ dendritic cells in systemic lupus erythematosus patients.
Nature communications
Yuan X,Qin X,Wang D,Zhang Z,Tang X,Gao X,Chen W,Sun L
Fri Jun 07 00:00:00 EDT 2019
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
Nature medicine
Johnson DC,Taabazuing CY,Okondo MC,Chui AJ,Rao SD,Brown FC,Reed C,Peguero E,de Stanchina E,Kentsis A,Bachovchin DA
300-19 was used in Cell Culture to identify an activator of CARD8 in human cells and indicate that its activation by small-molecule DPP8/9 inhibitors represents a new potential therapeutic strategy for AML.
Wed Aug 01 00:00:00 EDT 2018
Regulation of embryonic haematopoietic multipotency by EZH1.
Nature
Vo LT,Kinney MA,Liu X,Zhang Y,Barragan J,Sousa PM,Jha DK,Han A,Cesana M,Shao Z,North TE,Orkin SH,Doulatov S,Xu J,Daley GQ
Thu Jan 25 00:00:00 EST 2018
CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.
Cell
Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH
300-19 was used in In vitro experiments to study the mechanism for the ways in which CBFβ-SMMHC drives leukemia maintenance and show that inhibitors targeting chromatin activity may prove effective in inv(16) leukemia therapy.
Thu Jun 28 00:00:00 EDT 2018
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells.
Cell
Guzzi N,Cieśla M,Ngoc PCT,Lang S,Arora S,Dimitriou M,Pimková K,Sommarin MNE,Munita R,Lubas M,Lim Y,Okuyama K,Soneji S,Karlsson G,Hansson J,Jönsson G,Lund AH,Sigvardsson M,Hellström-Lindberg E,Hsieh AC,Bellodi C
Thu May 17 00:00:00 EDT 2018
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Cell
Su R,Dong L,Li C,Nachtergaele S,Wunderlich M,Qing Y,Deng X,Wang Y,Weng X,Hu C,Yu M,Skibbe J,Dai Q,Zou D,Wu T,Yu K,Weng H,Huang H,Ferchen K,Qin X,Zhang B,Qi J,Sasaki AT,Plas DR,Bradner JE,Wei M,Marcucci G,Jiang X,Mulloy JC,Jin J,He C,Chen J
Thu Jan 11 00:00:00 EST 2018
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 EST 2018
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Cell
Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S
Thu May 31 00:00:00 EDT 2018
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Cell
Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S
Thu May 31 00:00:00 EDT 2018
Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.
Immunity
Hosokawa H,Ungerbäck J,Wang X,Matsumoto M,Nakayama KI,Cohen SM,Tanaka T,Rothenberg EV
Tue Jun 19 00:00:00 EDT 2018
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Cancer cell
Jones CL,Stevens BM,D'Alessandro A,Reisz JA,Culp-Hill R,Nemkov T,Pei S,Khan N,Adane B,Ye H,Krug A,Reinhold D,Smith C,DeGregori J,Pollyea DA,Jordan CT
Mon Nov 12 00:00:00 EST 2018
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
Cell stem cell
Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A
300-19 was used in In vitro experiments to report on the involvement of innate pathogen recognition molecules in immune blocks to gene correction in primary human hematopoietic stem cells.
Thu Dec 06 00:00:00 EST 2018
Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.
Cell stem cell
Petrillo C,Thorne LG,Unali G,Schiroli G,Giordano AMS,Piras F,Cuccovillo I,Petit SJ,Ahsan F,Noursadeghi M,Clare S,Genovese P,Gentner B,Naldini L,Towers GJ,Kajaste-Rudnitski A
300-19 was used in In vitro experiments to report on the involvement of innate pathogen recognition molecules in immune blocks to gene correction in primary human hematopoietic stem cells.
Thu Dec 06 00:00:00 EST 2018
Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.
The Journal of experimental medicine
Khalil S,Delehanty L,Grado S,Holy M,White Z,Freeman K,Kurita R,Nakamura Y,Bullock G,Goldfarb A
Mon Feb 05 00:00:00 EST 2018
A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.
Developmental cell
Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T
300-19 was used in Cell Culture to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.
Mon Feb 05 00:00:00 EST 2018
Quality-Quantity Control Culture Enhances Vasculogenesis and Wound Healing Efficacy of Human Diabetic Peripheral Blood CD34+ Cells.
Stem cells translational medicine
Tanaka R,Masuda H,Fujimura S,Ito-Hirano R,Arita K,Kakinuma Y,Hagiwara H,Kado M,Hayashi A,Mita T,Ogawa T,Watada H,Mizuno H,Sawada N,Asahara T
Tue May 01 00:00:00 EDT 2018
X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery.
Molecular oncology
Zhou J,Lu X,Tan TZ,Chng WJ
Mon Jan 01 00:00:00 EST 2018
The Essential Role of Double-Stranded RNA-Dependent Antiviral Signaling in the Degradation of Nonself Single-Stranded RNA in Nonimmune Cells.
Journal of immunology (Baltimore, Md. : 1950)
Kimura S,Matsumiya T,Shiba Y,Nakanishi M,Hayakari R,Kawaguchi S,Yoshida H,Imaizumi T
Wed Aug 01 00:00:00 EDT 2018
Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis.
Cell reports
Osorio FG,Rosendahl Huber A,Oka R,Verheul M,Patel SH,Hasaart K,de la Fonteijne L,Varela I,Camargo FD,van Boxtel R
300-19 was used in Cell Culture to perform genomic analysis of the mutation accumulation of HSPCs.
Tue Nov 27 00:00:00 EST 2018
P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim.
Nature communications
Hu P,Nebreda AR,Hanenberg H,Kinnebrew GH,Ivan M,Yoder MC,Filippi MD,Broxmeyer HE,Kapur R
Wed Aug 29 00:00:00 EDT 2018
Human granulocytes undergo cell death via autophagy.
Cell death discovery
Kajiume T,Kobayashi M
Wed Oct 04 00:00:00 EDT 2023
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.
The Journal of biological chemistry
Seren S,Rashed Abouzaid M,Eulenberg-Gustavus C,Hirschfeld J,Nasr Soliman H,Jerke U,N'Guessan K,Dallet-Choisy S,Lesner A,Lauritzen C,Schacher B,Eickholz P,Nagy N,Szell M,Croix C,Viaud-Massuard MC,Al Farraj Aldosari A,Ragunatha S,Ibrahim Mostafa M,Giampieri F,Battino M,Cornillier H,Lorette G,Stephan JL,Goizet C,Pedersen J,Gauthier F,Jenne DE,Marchand-Adam S,Chapple IL,Kettritz R,Korkmaz B
Fri Aug 10 00:00:00 EDT 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
300-19 was used in Cell Culture to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 EDT 2018
Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.
Cell reports
Balan S,Arnold-Schrauf C,Abbas A,Couespel N,Savoret J,Imperatore F,Villani AC,Vu Manh TP,Bhardwaj N,Dalod M
300-19 was used in Cell Culture to develop a dendritic cell (DC) differentiation method from human CD34+ precursors leading to high yields of plasmacytoid DCs and both types of conventional DCs.
Tue Aug 14 00:00:00 EDT 2018
Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.
Nature communications
Laustsen A,Bak RO,Krapp C,Kjær L,Egedahl JH,Petersen CC,Pillai S,Tang HQ,Uldbjerg N,Porteus M,Roan NR,Nyegaard M,Denton PW,Jakobsen MR
Thu Aug 30 00:00:00 EDT 2018
Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons.
Scientific reports
DeRosa BA,El Hokayem J,Artimovich E,Garcia-Serje C,Phillips AW,Van Booven D,Nestor JE,Wang L,Cuccaro ML,Vance JM,Pericak-Vance MA,Cukier HN,Nestor MW,Dykxhoorn DM
Wed May 30 00:00:00 EDT 2018
Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes.
Nature communications
Stevens BM,Khan N,D'Alessandro A,Nemkov T,Winters A,Jones CL,Zhang W,Pollyea DA,Jordan CT
Wed Sep 12 00:00:00 EDT 2018
Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.
Stem cell reports
Garcia-Alegria E,Menegatti S,Fadlullah MZH,Menendez P,Lacaud G,Kouskoff V
Tue Nov 13 00:00:00 EST 2018
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
Nature communications
Sheng C,Jungverdorben J,Wiethoff H,Lin Q,Flitsch LJ,Eckert D,Hebisch M,Fischer J,Kesavan J,Weykopf B,Schneider L,Holtkamp D,Beck H,Till A,Wüllner U,Ziller MJ,Wagner W,Peitz M,Brüstle O
Tue Oct 02 00:00:00 EDT 2018
Reconstruction of complex single-cell trajectories using CellRouter.
Nature communications
Lummertz da Rocha E,Rowe RG,Lundin V,Malleshaiah M,Jha DK,Rambo CR,Li H,North TE,Collins JJ,Daley GQ
Thu Mar 01 00:00:00 EST 2018
Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation.
Scientific reports
Biechonski S,Olender L,Zipin-Roitman A,Yassin M,Aqaqe N,Marcu-Malina V,Rall-Scharpf M,Trottier M,Meyn MS,Wiesmüller L,Beider K,Raz Y,Grisaru D,Nagler A,Milyavsky M
Tue Apr 17 00:00:00 EDT 2018
Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.
Stem cell reports
Tusa I,Cheloni G,Poteti M,Gozzini A,DeSouza NH,Shan Y,Deng X,Gray NS,Li S,Rovida E,Dello Sbarba P
Tue Oct 09 00:00:00 EDT 2018
Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia.
Nature communications
Latham SL,Ehmke N,Reinke PYA,Taft MH,Eicke D,Reindl T,Stenzel W,Lyons MJ,Friez MJ,Lee JA,Hecker R,Frühwald MC,Becker K,Neuhann TM,Horn D,Schrock E,Niehaus I,Sarnow K,Grützmann K,Gawehn L,Klink B,Rump A,Chaponnier C,Figueiredo C,Knöfler R,Manstein DJ,Di Donato N
Fri Oct 12 00:00:00 EDT 2018
Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.
Scientific reports
MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH
Tue May 22 00:00:00 EDT 2018
Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.
Scientific reports
MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH
Tue May 22 00:00:00 EDT 2018
Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes.
Cell death & disease
Li Z,Li SP,Li RY,Zhu H,Liu X,Guo XL,Mu LL,Cai JJ,Bai F,Chen GQ,Hong DL
Tue May 01 00:00:00 EDT 2018
Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response.
Stem cell reports
Ueda N,Uemura Y,Zhang R,Kitayama S,Iriguchi S,Kawai Y,Yasui Y,Tatsumi M,Ueda T,Liu TY,Mizoro Y,Okada C,Watanabe A,Nakanishi M,Senju S,Nishimura Y,Kuzushima K,Kiyoi H,Naoe T,Kaneko S
Tue Jun 05 00:00:00 EDT 2018
MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Nature communications
Skucha A,Ebner J,Schmöllerl J,Roth M,Eder T,César-Razquin A,Stukalov A,Vittori S,Muhar M,Lu B,Aichinger M,Jude J,Müller AC,Győrffy B,Vakoc CR,Valent P,Bennett KL,Zuber J,Superti-Furga G,Grebien F
Fri May 18 00:00:00 EDT 2018
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.
Cell death & disease
Toofan P,Busch C,Morrison H,O'Brien S,Jørgensen H,Copland M,Wheadon H
Tue Sep 11 00:00:00 EDT 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 EDT 2018
Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Nature communications
Balcerek J,Jiang J,Li Y,Jiang Q,Holdreith N,Singh B,Chandra V,Lv K,Ren JG,Rozenova K,Li W,Greenberg RA,Tong W
Tue Sep 25 00:00:00 EDT 2018
BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation.
Nature
Raffel S,Falcone M,Kneisel N,Hansson J,Wang W,Lutz C,Bullinger L,Poschet G,Nonnenmacher Y,Barnert A,Bahr C,Zeisberger P,Przybylla A,Sohn M,Tönjes M,Erez A,Adler L,Jensen P,Scholl C,Fröhling S,Cocciardi S,Wuchter P,Thiede C,Flörcken A,Westermann J,Ehninger G,Lichter P,Hiller K,Hell R,Herrmann C,Ho AD,Krijgsveld J,Radlwimmer B,Trumpp A
Thu Nov 16 00:00:00 EST 2017
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.
Cell
Cantor JR,Abu-Remaileh M,Kanarek N,Freinkman E,Gao X,Louissaint A,Lewis CA,Sabatini DM
Thu Apr 06 00:00:00 EDT 2017
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Cell
Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I
300-19 was used in In vitro experiments to determine the role of TET2 deficiency in leukaemia stem cell maintenance.
Thu Sep 07 00:00:00 EDT 2017
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell
Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A
Thu May 18 00:00:00 EDT 2017
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Cell
Spencer DH,Russler-Germain DA,Ketkar S,Helton NM,Lamprecht TL,Fulton RS,Fronick CC,O'Laughlin M,Heath SE,Shinawi M,Westervelt P,Payton JE,Wartman LD,Welch JS,Wilson RK,Walter MJ,Link DC,DiPersio JF,Ley TJ
Thu Feb 23 00:00:00 EST 2017
Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification.
Immunity
Grajkowska LT,Ceribelli M,Lau CM,Warren ME,Tiniakou I,Nakandakari Higa S,Bunin A,Haecker H,Mirny LA,Staudt LM,Reizis B
Tue Jan 17 00:00:00 EST 2017
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
Mon Nov 13 00:00:00 EST 2017
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
Mon Nov 13 00:00:00 EST 2017
MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Cancer cell
Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P
Mon Jun 12 00:00:00 EDT 2017
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer cell
Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T
Mon Apr 10 00:00:00 EDT 2017
Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia.
Blood
Serafin V,Capuzzo G,Milani G,Minuzzo SA,Pinazza M,Bortolozzi R,Bresolin S,Porcù E,Frasson C,Indraccolo S,Basso G,Accordi B
Thu Dec 21 00:00:00 EST 2017
Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.
Autophagy
Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y
300-19 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.
Thu May 04 00:00:00 EDT 2017
Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.
Stem cells translational medicine
Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP
Wed Mar 01 00:00:00 EST 2017
Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.
Stem cells translational medicine
Gori JL,Butler JM,Kunar B,Poulos MG,Ginsberg M,Nolan DJ,Norgaard ZK,Adair JE,Rafii S,Kiem HP
Wed Mar 01 00:00:00 EST 2017
Curtailed T-cell activation curbs effector differentiation and generates CD8+ T cells with a naturally-occurring memory stem cell phenotype.
European journal of immunology
Zanon V,Pilipow K,Scamardella E,De Paoli F,De Simone G,Price DA,Martinez Usatorre A,Romero P,Mavilio D,Roberto A,Lugli E
Fri Sep 01 00:00:00 EDT 2017
CXCL12-CXCR4 Axis Is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but Not T Lymphoid Generation.
Journal of immunology (Baltimore, Md. : 1950)
Minami H,Nagaharu K,Nakamori Y,Ohishi K,Shimojo N,Kageyama Y,Matsumoto T,Sugimoto Y,Tawara I,Masuya M,Miwa H,Katayama N
Sun Oct 01 00:00:00 EDT 2017
Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34+ cells.
Cell cycle (Georgetown, Tex.)
Dhenge A,Limbkar K,Melinkeri S,Kale VP,Limaye L
300-19 was used in Cell Culture to examine the role of poly-unsaturated fatty acids in platelet production.
Fri May 19 00:00:00 EDT 2017
KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.
Nature communications
Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J
Fri Nov 10 00:00:00 EST 2017
Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia.
Oncotarget
Jiang Z,Wu D,Ye W,Weng J,Lai P,Shi P,Guo X,Huang G,Deng Q,Tang Y,Zhao H,Cui S,Lin S,Wang S,Li B,Wu Q,Li Y,Liu P,Pei D,Du X,Yao Y,Li P
300-19 was used in Cell Culture to develop a defined condition for the ex vivo expansion of primary B-ALL cells that is suitable for high-throughput screening of novel compounds.
Tue Dec 05 00:00:00 EST 2017
Differentiation of Human Induced Pluripotent Stem Cells (iPS Cells) and Embryonic Stem Cells (ES Cells) into Dendritic Cell (DC) Subsets.
Bio-protocol
Sontag S,Förster M,Seré K,Zenke M
300-19 was used in Sample Preparation to study subset specification and function of human dendritic cells (DCs) using a protocol which generates classical cDC1, classical cDC2 and plasmacytoid pDC in vitro from human induced pluripotent stem cells (iPS) cells or ES cells.
Sat Aug 05 00:00:00 EDT 2017
Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities.
Oncoimmunology
Van Caeneghem Y,De Munter S,Tieppo P,Goetgeluk G,Weening K,Verstichel G,Bonte S,Taghon T,Leclercq G,Kerre T,Debets R,Vermijlen D,Abken H,Vandekerckhove B
300-19 was used in Flow cytometry/Cell sorting to show that cord blood hematopoietic progenitor cells generate allogeneic CD3-antigen receptor (AR)+T cells which effectively eliminate malignant cells and limit graft versus host disease occurrence.
Tue Jan 12 00:00:00 EST 2021
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Fri Sep 29 00:00:00 EDT 2017
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.
Nature communications
Veglia F,Tyurin VA,Mohammadyani D,Blasi M,Duperret EK,Donthireddy L,Hashimoto A,Kapralov A,Amoscato A,Angelini R,Patel S,Alicea-Torres K,Weiner D,Murphy ME,Klein-Seetharaman J,Celis E,Kagan VE,Gabrilovich DI
Thu Dec 14 00:00:00 EST 2017
Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation.
Stem cell reports
Di Tullio A,Passaro D,Rouault-Pierre K,Purewal S,Bonnet D
Tue Jul 11 00:00:00 EDT 2017
Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.
Stem cell reports
Li Y,Brauer PM,Singh J,Xhiku S,Yoganathan K,Zúñiga-Pflücker JC,Anderson MK
Tue Sep 12 00:00:00 EDT 2017
Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines.
EBioMedicine
Hayashi M,Aoshi T,Haseda Y,Kobiyama K,Wijaya E,Nakatsu N,Igarashi Y,Standley DM,Yamada H,Honda-Okubo Y,Hara H,Saito T,Takai T,Coban C,Petrovsky N,Ishii KJ
300-19 was used in In vitro experiments to study the immunological characteristics and mechanism of action of delta inulin-derived microparticle Advax.
Wed Feb 01 00:00:00 EST 2017
Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.
Stem cell reports
Zeng J,Tang SY,Toh LL,Wang S
Tue Dec 12 00:00:00 EST 2017
Enforced GFI1 expression impedes human and murine leukemic cell growth.
Scientific reports
Hönes JM,Thivakaran A,Botezatu L,Patnana P,Castro SVDC,Al-Matary YS,Schütte J,Fischer KBI,Vassen L,Görgens A,Dührsen U,Giebel B,Khandanpour C
Thu Nov 16 00:00:00 EST 2017
TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.
Scientific reports
Pike KA,Hatzihristidis T,Bussières-Marmen S,Robert F,Desai N,Miranda-Saavedra D,Pelletier J,Tremblay ML
Mon Oct 16 00:00:00 EDT 2017
Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery.
ACS biomaterials science & engineering
Liu FD,Pishesha N,Poon Z,Kaushik T,Van Vliet KJ
300-19 was used in Cell Culture to leverage cell-material interactions in vitro to induce human bone marrow-derived MSCs to preferentially secrete factors that are beneficial to hematopoietic cell proliferation.
Mon Dec 11 00:00:00 EST 2017
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nature biotechnology
Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR
300-19 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.
Tue Nov 01 00:00:00 EDT 2016
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
Cell
Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL
Thu Apr 07 00:00:00 EDT 2016
Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.
Immunity
Kristiansen TA,Jaensson Gyllenbäck E,Zriwil A,Björklund T,Daniel JA,Sitnicka E,Soneji S,Bryder D,Yuan J
Tue Aug 16 00:00:00 EDT 2016
UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.
Blood
Samudio I,Rezvani K,Shaim H,Hofs E,Ngom M,Bu L,Liu G,Lee JT,Imren S,Lam V,Poon GF,Ghaedi M,Takei F,Humphries K,Jia W,Krystal G
Thu May 26 00:00:00 EDT 2016
Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.
Blood
Dahlin JS,Malinovschi A,Öhrvik H,Sandelin M,Janson C,Alving K,Hallgren J
Thu Jan 28 00:00:00 EST 2016
Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion.
Blood
Chesnais V,Renneville A,Toma A,Lambert J,Passet M,Dumont F,Chevret S,Lejeune J,Raimbault A,Stamatoullas A,Rose C,Beyne-Rauzy O,Delaunay J,Solary E,Fenaux P,Dreyfus F,Preudhomme C,Kosmider O,Fontenay M
Thu Feb 11 00:00:00 EST 2016
Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors.
The Journal of clinical investigation
Sanges D,Simonte G,Di Vicino U,Romo N,Pinilla I,Nicolás M,Cosma MP
Mon Aug 01 00:00:00 EDT 2016
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.
The Journal of clinical investigation
Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J
Thu Dec 01 00:00:00 EST 2016
Targeting MTHFD2 in acute myeloid leukemia.
The Journal of experimental medicine
Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K
Mon Jun 27 00:00:00 EDT 2016
Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.
The Journal of experimental medicine
Azad P,Zhao HW,Cabrales PJ,Ronen R,Zhou D,Poulsen O,Appenzeller O,Hsiao YH,Bafna V,Haddad GG
Mon Nov 14 00:00:00 EST 2016
Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease.
Experimental & molecular medicine
Son MY,Lee MO,Jeon H,Seol B,Kim JH,Chang JS,Cho YS
Fri May 13 00:00:00 EDT 2016
Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.
Stem cells translational medicine
Jackson M,Ma R,Taylor AH,Axton RA,Easterbrook J,Kydonaki M,Olivier E,Marenah L,Stanley EG,Elefanty AG,Mountford JC,Forrester LM
300-19 was used in Cell Culture to investigate whether activation of exogenous HOXB4 promotes the production of more mature, definitive red blood cells.
Mon Aug 01 00:00:00 EDT 2016
Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.
Stem cells (Dayton, Ohio)
Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL
Wed Jun 01 00:00:00 EDT 2016
Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis.
Stem cells (Dayton, Ohio)
Sweeney CL,Teng R,Wang H,Merling RK,Lee J,Choi U,Koontz S,Wright DG,Malech HL
Wed Jun 01 00:00:00 EDT 2016
Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an AML Diagnostic Sample Containing the t(8;21) Translocation.
Stem cells (Dayton, Ohio)
Hoffmann D,Göhring G,Heuser M,Ganser A,Schambach A,Morgan MA
Tue Mar 01 00:00:00 EST 2016
Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in Mice.
Journal of immunology (Baltimore, Md. : 1950)
von Wnuck Lipinski K,Sattler K,Peters S,Weske S,Keul P,Klump H,Heusch G,Göthert JR,Levkau B
Mon Feb 15 00:00:00 EST 2016
CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.
Cell cycle (Georgetown, Tex.)
Moreno-Lorenzana D,Avilés-Vazquez S,Sandoval Esquivel MA,Alvarado-Moreno A,Ortiz-Navarrete V,Torres-Martínez H,Ayala-Sánchez M,Mayani H,Chavez-Gonzalez A
300-19 was used in Sample Preparation (FC/FACS) to analyze the cell cycle status, levels of several CDKIs and the subcellular localization of such molecules in different Chronic Myeloid Leukemia (CML) cell lines, as well as primary CD34(+)CD38(-)lin(-) LSC and HSC to understand the role of Cyclin Dependent Kinase Inhibitors in CML LSC permanence after tyrosine kinase inhibitor (TKI) treatment.
Mon May 02 00:00:00 EDT 2016
Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus.
Scientific reports
Uematsu T,Fujita T,Nakaoka HJ,Hara T,Kobayashi N,Murakami Y,Seiki M,Sakamoto T
Thu Nov 24 00:00:00 EST 2016
GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.
Stem cell reports
D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II
Tue Feb 09 00:00:00 EST 2016
BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors.
Cell death & disease
Korfi K,Smith M,Swan J,Somervaille TC,Dhomen N,Marais R
Thu Apr 07 00:00:00 EDT 2016
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
Nature communications
Ding X,Ray Chaudhuri A,Callen E,Pang Y,Biswas K,Klarmann KD,Martin BK,Burkett S,Cleveland L,Stauffer S,Sullivan T,Dewan A,Marks H,Tubbs AT,Wong N,Buehler E,Akagi K,Martin SE,Keller JR,Nussenzweig A,Sharan SK
Mon Aug 08 00:00:00 EDT 2016
Acetylation of C/EBPα inhibits its granulopoietic function.
Nature communications
Bararia D,Kwok HS,Welner RS,Numata A,Sárosi MB,Yang H,Wee S,Tschuri S,Ray D,Weigert O,Levantini E,Ebralidze AK,Gunaratne J,Tenen DG
Wed Mar 23 00:00:00 EDT 2016
RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine.
Scientific reports
Hayashi M,Aoshi T,Ozasa K,Kusakabe T,Momota M,Haseda Y,Kobari S,Kuroda E,Kobiyama K,Coban C,Ishii KJ
Mon Jul 04 00:00:00 EDT 2016
Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.
Nature communications
Adair JE,Waters T,Haworth KG,Kubek SP,Trobridge GD,Hocum JD,Heimfeld S,Kiem HP
Thu Oct 20 00:00:00 EDT 2016
Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.
Scientific reports
Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H
Wed May 18 00:00:00 EDT 2016
Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.
Scientific reports
Chen JJ,Gao XT,Yang L,Fu W,Liang L,Li JC,Hu B,Sun ZJ,Huang SY,Zhang YZ,Liang YM,Qin HY,Han H
Wed May 18 00:00:00 EDT 2016
Chromothriptic cure of WHIM syndrome.
Cell
McDermott DH,Gao JL,Liu Q,Siwicki M,Martens C,Jacobs P,Velez D,Yim E,Bryke CR,Hsu N,Dai Z,Marquesen MM,Stregevsky E,Kwatemaa N,Theobald N,Long Priel DA,Pittaluga S,Raffeld MA,Calvo KR,Maric I,Desmond R,Holmes KL,Kuhns DB,Balabanian K,Bachelerie F,Porcella SF,Malech HL,Murphy PM
Thu Feb 12 00:00:00 EST 2015
Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.
Blood
Kinkel SA,Galeev R,Flensburg C,Keniry A,Breslin K,Gilan O,Lee S,Liu J,Chen K,Gearing LJ,Moore DL,Alexander WS,Dawson M,Majewski IJ,Oshlack A,Larsson J,Blewitt ME
Thu Mar 19 00:00:00 EDT 2015
Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.
Blood
Maude SL,Dolai S,Delgado-Martin C,Vincent T,Robbins A,Selvanathan A,Ryan T,Hall J,Wood AC,Tasian SK,Hunger SP,Loh ML,Mullighan CG,Wood BL,Hermiston ML,Grupp SA,Lock RB,Teachey DT
Thu Mar 12 00:00:00 EDT 2015
Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.
Blood
Hoban MD,Cost GJ,Mendel MC,Romero Z,Kaufman ML,Joglekar AV,Ho M,Lumaquin D,Gray D,Lill GR,Cooper AR,Urbinati F,Senadheera S,Zhu A,Liu PQ,Paschon DE,Zhang L,Rebar EJ,Wilber A,Wang X,Gregory PD,Holmes MC,Reik A,Hollis RP,Kohn DB
Thu Apr 23 00:00:00 EDT 2015
Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.
Blood
Jang IH,Lu YF,Zhao L,Wenzel PL,Kume T,Datta SM,Arora N,Guiu J,Lagha M,Kim PG,Do EK,Kim JH,Schlaeger TM,Zon LI,Bigas A,Burns CE,Daley GQ
Thu Feb 26 00:00:00 EST 2015
A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor.
Blood
Belay E,Miller CP,Kortum AN,Torok-Storb B,Blau CA,Emery DW
Thu Feb 05 00:00:00 EST 2015
Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.
Blood
Sinha S,Thomas D,Yu L,Gentles AJ,Jung N,Corces-Zimmerman MR,Chan SM,Reinisch A,Feinberg AP,Dill DL,Majeti R
Thu Jan 08 00:00:00 EST 2015
MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.
Blood
Buechele C,Breese EH,Schneidawind D,Lin CH,Jeong J,Duque-Afonso J,Wong SH,Smith KS,Negrin RS,Porteus M,Cleary ML
Thu Oct 01 00:00:00 EDT 2015
Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.
Blood
Schwartz C,Willebrand R,Huber S,Rupec RA,Wu D,Locksley R,Voehringer D
Thu Jun 18 00:00:00 EDT 2015
Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.
The Journal of clinical investigation
Meldi K,Qin T,Buchi F,Droin N,Sotzen J,Micol JB,Selimoglu-Buet D,Masala E,Allione B,Gioia D,Poloni A,Lunghi M,Solary E,Abdel-Wahab O,Santini V,Figueroa ME
Fri May 01 00:00:00 EDT 2015
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
The Journal of clinical investigation
Gori JL,Butler JM,Chan YY,Chandrasekaran D,Poulos MG,Ginsberg M,Nolan DJ,Elemento O,Wood BL,Adair JE,Rafii S,Kiem HP
Mon Mar 02 00:00:00 EST 2015
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
The Journal of clinical investigation
Gori JL,Butler JM,Chan YY,Chandrasekaran D,Poulos MG,Ginsberg M,Nolan DJ,Elemento O,Wood BL,Adair JE,Rafii S,Kiem HP
Mon Mar 02 00:00:00 EST 2015
IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.
The Journal of clinical investigation
Matino D,Gargaro M,Santagostino E,Di Minno MN,Castaman G,Morfini M,Rocino A,Mancuso ME,Di Minno G,Coppola A,Talesa VN,Volpi C,Vacca C,Orabona C,Iannitti R,Mazzucconi MG,Santoro C,Tosti A,Chiappalupi S,Sorci G,Tagariello G,Belvini D,Radossi P,Landolfi R,Fuchs D,Boon L,Pirro M,Marchesini E,Grohmann U,Puccetti P,Iorio A,Fallarino F
Thu Oct 01 00:00:00 EDT 2015
B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.
Autophagy
Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT
300-19 was used in Cell Culture to demonstrate that autophagy plays an essential role in TLR7 activation of B cells for the induction of systemic lupus erythematosus.
Mon Apr 18 00:00:00 EDT 2016
Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages.
Proceedings of the National Academy of Sciences of the United States of America
McClellan JS,Dove C,Gentles AJ,Ryan CE,Majeti R
Tue Mar 31 00:00:00 EDT 2015
Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.
Proceedings of the National Academy of Sciences of the United States of America
Yin J,Leavenworth JW,Li Y,Luo Q,Xie H,Liu X,Huang S,Yan H,Fu Z,Zhang LY,Zhang L,Hao J,Wu X,Deng X,Roberts CW,Orkin SH,Cantor H,Wang X
Tue Dec 29 00:00:00 EST 2015
Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.
British journal of haematology
Sjögren SE,Siva K,Soneji S,George AJ,Winkler M,Jaako P,Wlodarski M,Karlsson S,Hannan RD,Flygare J
Sun Nov 01 00:00:00 EDT 2015
TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.
European journal of immunology
Temizoz B,Kuroda E,Ohata K,Jounai N,Ozasa K,Kobiyama K,Aoshi T,Ishii KJ
Wed Apr 01 00:00:00 EDT 2015
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.
Stem cells (Dayton, Ohio)
Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS
Wed Apr 01 00:00:00 EDT 2015
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.
Stem cells (Dayton, Ohio)
Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS
Wed Apr 01 00:00:00 EDT 2015
Molecular signature of erythroblast enucleation in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Rouzbeh S,Kobari L,Cambot M,Mazurier C,Hebert N,Faussat AM,Durand C,Douay L,Lapillonne H
Sat Aug 01 00:00:00 EDT 2015
Enrichment of human hematopoietic stem/progenitor cells facilitates transduction for stem cell gene therapy.
Stem cells (Dayton, Ohio)
Baldwin K,Urbinati F,Romero Z,Campo-Fernandez B,Kaufman ML,Cooper AR,Masiuk K,Hollis RP,Kohn DB
Fri May 01 00:00:00 EDT 2015
Endogenous intracellular cathelicidin enhances TLR9 activation in dendritic cells and macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Nakagawa Y,Gallo RL
Sun Feb 01 00:00:00 EST 2015
TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection.
Journal of immunology (Baltimore, Md. : 1950)
Hotz C,Roetzer LC,Huber T,Sailer A,Oberson A,Treinies M,Heidegger S,Herbst T,Endres S,Bourquin C
Sun Nov 01 00:00:00 EDT 2015
Identification of Thiostrepton as a Novel Inhibitor for Psoriasis-like Inflammation Induced by TLR7-9.
Journal of immunology (Baltimore, Md. : 1950)
Lai CY,Yeh DW,Lu CH,Liu YL,Huang LR,Kao CY,Chen HY,Huang CY,Chang CH,Luo Y,Xiang R,Chuang TH
Thu Oct 15 00:00:00 EDT 2015
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem cell reports
Garate Z,Quintana-Bustamante O,Crane AM,Olivier E,Poirot L,Galetto R,Kosinski P,Hill C,Kung C,Agirre X,Orman I,Cerrato L,Alberquilla O,Rodriguez-Fornes F,Fusaki N,Garcia-Sanchez F,Maia TM,Ribeiro ML,Sevilla J,Prosper F,Jin S,Mountford J,Guenechea G,Gouble A,Bueren JA,Davis BR,Segovia JC
Tue Dec 08 00:00:00 EST 2015
Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity.
Scientific reports
Uematsu T,Iizasa E,Kobayashi N,Yoshida H,Hara H
Wed Dec 02 00:00:00 EST 2015
Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.
Molecular therapy. Methods & clinical development
Wielgosz MM,Kim YS,Carney GG,Zhan J,Reddivari M,Coop T,Heath RJ,Brown SA,Nienhuis AW
300-19 was used in In vitro experiments to show that the producer cell line and the specific monoclonal antibody will facilitate the development of a clinical protocol for gene transfer into WAS protein deficient stem cells.
Mon Jun 08 00:00:00 EDT 2015
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific reports
Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J
Mon Oct 12 00:00:00 EDT 2015
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific reports
Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J
Mon Oct 12 00:00:00 EDT 2015
TALENs-mediated gene disruption of FLT3 in leukemia cells: Using genome-editing approach for exploring the molecular basis of gene abnormality.
Scientific reports
Wang J,Li T,Zhou M,Hu Z,Zhou X,Zhou S,Wang N,Huang L,Zhao L,Cao Y,Xiao M,Ma D,Zhou P,Shang Z,Zhou J
Wed Dec 16 00:00:00 EST 2015
TALENs-mediated gene disruption of FLT3 in leukemia cells: Using genome-editing approach for exploring the molecular basis of gene abnormality.
Scientific reports
Wang J,Li T,Zhou M,Hu Z,Zhou X,Zhou S,Wang N,Huang L,Zhao L,Cao Y,Xiao M,Ma D,Zhou P,Shang Z,Zhou J
Wed Dec 16 00:00:00 EST 2015
Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.
Molecular therapy. Methods & clinical development
Prel A,Caval V,Gayon R,Ravassard P,Duthoit C,Payen E,Maouche-Chretien L,Creneguy A,Nguyen TH,Martin N,Piver E,Sevrain R,Lamouroux L,Leboulch P,Deschaseaux F,Bouillé P,Sensébé L,Pagès JC
Tue Nov 03 00:00:00 EST 2015
Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.
Stem cell reports
Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F
Tue Oct 13 00:00:00 EDT 2015
Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.
Scientific reports
Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y
Fri Dec 18 00:00:00 EST 2015
NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells.
The Journal of biological chemistry
Stanicka J,Russell EG,Woolley JF,Cotter TG
Fri Apr 10 00:00:00 EDT 2015
The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
Stem cell reports
Zhang J,Vakhrusheva O,Bandi SR,Demirel Ö,Kazi JU,Fernandes RG,Jakobi K,Eichler A,Rönnstrand L,Rieger MA,Carpino N,Serve H,Brandts CH
Tue Oct 13 00:00:00 EDT 2015
PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm.
Scientific reports
Ono R,Kaisho T,Tanaka T
Fri Dec 18 00:00:00 EST 2015
Construction of stable packaging cell lines for clinical lentiviral vector production.
Scientific reports
Sanber KS,Knight SB,Stephen SL,Bailey R,Escors D,Minshull J,Santilli G,Thrasher AJ,Collins MK,Takeuchi Y
Thu Mar 12 00:00:00 EDT 2015
Targeted genome editing in human repopulating haematopoietic stem cells.
Nature
Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L
Thu Jun 12 00:00:00 EDT 2014
Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.
Blood
Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW
Thu Feb 27 00:00:00 EST 2014
Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors.
Blood
Bots M,Verbrugge I,Martin BP,Salmon JM,Ghisi M,Baker A,Stanley K,Shortt J,Ossenkoppele GJ,Zuber J,Rappaport AR,Atadja P,Lowe SW,Johnstone RW
Thu Feb 27 00:00:00 EST 2014
STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.
Blood
Gough DJ,Marié IJ,Lobry C,Aifantis I,Levy DE
Thu Oct 02 00:00:00 EDT 2014
MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells.
Blood
Liu S,Yin L,Stroopinsky D,Rajabi H,Puissant A,Stegmaier K,Avigan D,Kharbanda S,Kufe D,Stone R
Thu Jan 30 00:00:00 EST 2014
Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells.
Blood
Wang CX,Sather BD,Wang X,Adair J,Khan I,Singh S,Lang S,Adams A,Curinga G,Kiem HP,Miao CH,Rawlings DJ,Torbett BE
Thu Aug 07 00:00:00 EDT 2014
Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice.
Blood
Zhang SL,Wang X,Manna S,Zlotoff DA,Bryson JL,Blazar BR,Bhandoola A
Thu Jul 10 00:00:00 EDT 2014
The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.
Blood
Yang Z,Augustin J,Chang C,Hu J,Shah K,Chang CW,Townes T,Jiang H
Thu Sep 25 00:00:00 EDT 2014
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
The Journal of clinical investigation
Smeets MF,DeLuca E,Wall M,Quach JM,Chalk AM,Deans AJ,Heierhorst J,Purton LE,Izon DJ,Walkley CR
Fri Aug 01 00:00:00 EDT 2014
RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.
The Journal of experimental medicine
Verma R,Su S,McCrann DJ,Green JM,Leu K,Young PR,Schatz PJ,Silva JC,Stokes MP,Wojchowski DM
Mon Aug 25 00:00:00 EDT 2014
BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.
The Journal of experimental medicine
Berres ML,Lim KP,Peters T,Price J,Takizawa H,Salmon H,Idoyaga J,Ruzo A,Lupo PJ,Hicks MJ,Shih A,Simko SJ,Abhyankar H,Chakraborty R,Leboeuf M,Beltrão M,Lira SA,Heym KM,Bigley V,Collin M,Manz MG,McClain K,Merad M,Allen CE
Mon Apr 07 00:00:00 EDT 2014
ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2.
The Journal of experimental medicine
Ghosh HS,Ceribelli M,Matos I,Lazarovici A,Bussemaker HJ,Lasorella A,Hiebert SW,Liu K,Staudt LM,Reizis B
Mon Jul 28 00:00:00 EDT 2014
Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals.
Proceedings of the National Academy of Sciences of the United States of America
Zarin P,Wong GW,Mohtashami M,Wiest DL,Zúñiga-Pflücker JC
Tue Apr 15 00:00:00 EDT 2014
Quantitative and stoichiometric analysis of the microRNA content of exosomes.
Proceedings of the National Academy of Sciences of the United States of America
Chevillet JR,Kang Q,Ruf IK,Briggs HA,Vojtech LN,Hughes SM,Cheng HH,Arroyo JD,Meredith EK,Gallichotte EN,Pogosova-Agadjanyan EL,Morrissey C,Stirewalt DL,Hladik F,Yu EY,Higano CS,Tewari M
Tue Oct 14 00:00:00 EDT 2014
Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist.
Proceedings of the National Academy of Sciences of the United States of America
Kobiyama K,Aoshi T,Narita H,Kuroda E,Hayashi M,Tetsutani K,Koyama S,Mochizuki S,Sakurai K,Katakai Y,Yasutomi Y,Saijo S,Iwakura Y,Akira S,Coban C,Ishii KJ
Tue Feb 25 00:00:00 EST 2014
The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia.
Cell death and differentiation
Gong JN,Yu J,Lin HS,Zhang XH,Yin XL,Xiao Z,Wang F,Wang XS,Su R,Shen C,Zhao HL,Ma YN,Zhang JW
Wed Jan 01 00:00:00 EST 2014
Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model.
Molecular therapy. Nucleic acids
Haemmerle R,Phaltane R,Rothe M,Schröder S,Schambach A,Moritz T,Modlich U
Tue Oct 07 00:00:00 EDT 2014
Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.
Blood cancer journal
Askmyr M,Ågerstam H,Lilljebjörn H,Hansen N,Karlsson C,von Palffy S,Landberg N,Högberg C,Lassen C,Rissler M,Richter J,Ehinger M,Järås M,Fioretos T
Fri Dec 12 00:00:00 EST 2014
Engineering the human thymic microenvironment to support thymopoiesis in vivo.
Stem cells (Dayton, Ohio)
Chung B,Montel-Hagen A,Ge S,Blumberg G,Kim K,Klein S,Zhu Y,Parekh C,Balamurugan A,Yang OO,Crooks GM
Mon Sep 01 00:00:00 EDT 2014
EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300.
Stem cells (Dayton, Ohio)
Zheng WW,Dong XM,Yin RH,Xu FF,Ning HM,Zhang MJ,Xu CW,Yang Y,Ding YL,Wang ZD,Zhao WB,Tang LJ,Chen H,Wang XH,Zhan YQ,Yu M,Ge CH,Li CY,Yang XM
Fri Aug 01 00:00:00 EDT 2014
Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling.
Stem cells (Dayton, Ohio)
Fernandez I,Ooi TP,Roy K
Wed Jan 01 00:00:00 EST 2014
Conversion of human fibroblasts into monocyte-like progenitor cells.
Stem cells (Dayton, Ohio)
Pulecio J,Nivet E,Sancho-Martinez I,Vitaloni M,Guenechea G,Xia Y,Kurian L,Dubova I,Bueren J,Laricchia-Robbio L,Belmonte JCI
Sat Nov 01 00:00:00 EDT 2014
Conversion of human fibroblasts into monocyte-like progenitor cells.
Stem cells (Dayton, Ohio)
Pulecio J,Nivet E,Sancho-Martinez I,Vitaloni M,Guenechea G,Xia Y,Kurian L,Dubova I,Bueren J,Laricchia-Robbio L,Belmonte JCI
Sat Nov 01 00:00:00 EDT 2014
Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ-producing T cells.
Journal of immunology (Baltimore, Md. : 1950)
Mori T,Iwasaki Y,Seki Y,Iseki M,Katayama H,Yamamoto K,Takatsu K,Takaki S
Fri Aug 15 00:00:00 EDT 2014
Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Balan S,Ollion V,Colletti N,Chelbi R,Montanana-Sanchis F,Liu H,Vu Manh TP,Sanchez C,Savoret J,Perrot I,Doffin AC,Fossum E,Bechlian D,Chabannon C,Bogen B,Asselin-Paturel C,Shaw M,Soos T,Caux C,Valladeau-Guilemond J,Dalod M
Fri Aug 15 00:00:00 EDT 2014
X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women.
Journal of immunology (Baltimore, Md. : 1950)
Laffont S,Rouquié N,Azar P,Seillet C,Plumas J,Aspord C,Guéry JC
Mon Dec 01 00:00:00 EST 2014
X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women.
Journal of immunology (Baltimore, Md. : 1950)
Laffont S,Rouquié N,Azar P,Seillet C,Plumas J,Aspord C,Guéry JC
Mon Dec 01 00:00:00 EST 2014
3-Deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase, promotes erythroid differentiation.
The Journal of biological chemistry
Fujiwara T,Saitoh H,Inoue A,Kobayashi M,Okitsu Y,Katsuoka Y,Fukuhara N,Onishi Y,Ishizawa K,Ichinohasama R,Harigae H
Fri Mar 21 00:00:00 EDT 2014
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.
Cell
King B,Trimarchi T,Reavie L,Xu L,Mullenders J,Ntziachristos P,Aranda-Orgilles B,Perez-Garcia A,Shi J,Vakoc C,Sandy P,Shen SS,Ferrando A,Aifantis I
Thu Jun 20 00:00:00 EDT 2013
Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.
Blood
Mace EM,Hsu AP,Monaco-Shawver L,Makedonas G,Rosen JB,Dropulic L,Cohen JI,Frenkel EP,Bagwell JC,Sullivan JL,Biron CA,Spalding C,Zerbe CS,Uzel G,Holland SM,Orange JS
Thu Apr 04 00:00:00 EDT 2013
RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.
Blood
Harada Y,Inoue D,Ding Y,Imagawa J,Doki N,Matsui H,Yahata T,Matsushita H,Ando K,Sashida G,Iwama A,Kitamura T,Harada H
Thu Apr 25 00:00:00 EDT 2013
Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells.
Blood
Merling RK,Sweeney CL,Choi U,De Ravin SS,Myers TG,Otaizo-Carrasquero F,Pan J,Linton G,Chen L,Koontz S,Theobald NL,Malech HL
Thu Apr 04 00:00:00 EDT 2013
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.
Blood
Bolton-Gillespie E,Schemionek M,Klein HU,Flis S,Hoser G,Lange T,Nieborowska-Skorska M,Maier J,Kerstiens L,Koptyra M,Müller MC,Modi H,Stoklosa T,Seferynska I,Bhatia R,Holyoake TL,Koschmieder S,Skorski T
Thu May 16 00:00:00 EDT 2013
PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.
Blood
Kauskot A,Vandenbriele C,Louwette S,Gijsbers R,Tousseyn T,Freson K,Verhamme P,Hoylaerts MF
Thu Jun 27 00:00:00 EDT 2013
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
Blood
Klco JM,Spencer DH,Lamprecht TL,Sarkaria SM,Wylie T,Magrini V,Hundal J,Walker J,Varghese N,Erdmann-Gilmore P,Lichti CF,Meyer MR,Townsend RR,Wilson RK,Mardis ER,Ley TJ
Thu Feb 28 00:00:00 EST 2013
Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.
The Journal of clinical investigation
Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN
Thu Aug 01 00:00:00 EDT 2013
β-globin gene transfer to human bone marrow for sickle cell disease.
The Journal of clinical investigation
Romero Z,Urbinati F,Geiger S,Cooper AR,Wherley J,Kaufman ML,Hollis RP,de Assin RR,Senadheera S,Sahagian A,Jin X,Gellis A,Wang X,Gjertson D,Deoliveira S,Kempert P,Shupien S,Abdel-Azim H,Walters MC,Meiselman HJ,Wenby RB,Gruber T,Marder V,Coates TD,Kohn DB
Mon Jul 01 00:00:00 EDT 2013
Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance.
The Journal of experimental medicine
Singh SK,Williams CA,Klarmann K,Burkett SS,Keller JR,Oberdoerffer P
Mon May 06 00:00:00 EDT 2013
Notch pathway activation targets AML-initiating cell homeostasis and differentiation.
The Journal of experimental medicine
Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I
Mon Feb 11 00:00:00 EST 2013
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.
Molecular therapy : the journal of the American Society of Gene Therapy
Scaramuzza S,Biasco L,Ripamonti A,Castiello MC,Loperfido M,Draghici E,Hernandez RJ,Benedicenti F,Radrizzani M,Salomoni M,Ranzani M,Bartholomae CC,Vicenzi E,Finocchi A,Bredius R,Bosticardo M,Schmidt M,von Kalle C,Montini E,Biffi A,Roncarolo MG,Naldini L,Villa A,Aiuti A
Tue Jan 01 00:00:00 EST 2013
Galectin-1 prolongs survival of mouse liver allografts from Flt3L-pretreated donors.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Ye Y,Yan S,Jiang G,Zhou L,Xie H,Xie X,Yu X,Ding Y,Tian J,Dai Y,Zheng S
Fri Mar 01 00:00:00 EST 2013
Galectin-1 prolongs survival of mouse liver allografts from Flt3L-pretreated donors.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Ye Y,Yan S,Jiang G,Zhou L,Xie H,Xie X,Yu X,Ding Y,Tian J,Dai Y,Zheng S
Fri Mar 01 00:00:00 EST 2013
Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.
Journal of immunology (Baltimore, Md. : 1950)
Yamazaki C,Sugiyama M,Ohta T,Hemmi H,Hamada E,Sasaki I,Fukuda Y,Yano T,Nobuoka M,Hirashima T,Iizuka A,Sato K,Tanaka T,Hoshino K,Kaisho T
Sat Jun 15 00:00:00 EDT 2013
Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Imai K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y
Sat Jun 15 00:00:00 EDT 2013
Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃.
Journal of immunology (Baltimore, Md. : 1950)
Sato T,Kitawaki T,Fujita H,Iwata M,Iyoda T,Inaba K,Ohteki T,Hasegawa S,Kawada K,Sakai Y,Ikeuchi H,Nakase H,Niwa A,Takaori-Kondo A,Kadowaki N
Sun Sep 15 00:00:00 EDT 2013
Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.
PloS one
Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK
Wed Jul 03 00:00:00 EDT 2013
Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.
PloS one
Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK
Wed Jul 03 00:00:00 EDT 2013
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.
Cell
Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA
Fri Jun 08 00:00:00 EDT 2012
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.
Nature methods
Certo MT,Gwiazda KS,Kuhar R,Sather B,Curinga G,Mandt T,Brault M,Lambert AR,Baxter SK,Jacoby K,Ryu BY,Kiem HP,Gouble A,Paques F,Rawlings DJ,Scharenberg AM
Mon Oct 01 00:00:00 EDT 2012
HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.
Blood
Wong GW,Knowles GC,Mak TW,Ferrando AA,Zúñiga-Pflücker JC
Thu Aug 16 00:00:00 EDT 2012
FANCL ubiquitinates β-catenin and enhances its nuclear function.
Blood
Dao KH,Rotelli MD,Petersen CL,Kaech S,Nelson WD,Yates JE,Hanlon Newell AE,Olson SB,Druker BJ,Bagby GC
Thu Jul 12 00:00:00 EDT 2012
The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.
Blood
Karrich JJ,Balzarolo M,Schmidlin H,Libouban M,Nagasawa M,Gentek R,Kamihira S,Maeda T,Amsen D,Wolkers MC,Blom B
Thu May 31 00:00:00 EDT 2012
The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.
Blood
Karrich JJ,Balzarolo M,Schmidlin H,Libouban M,Nagasawa M,Gentek R,Kamihira S,Maeda T,Amsen D,Wolkers MC,Blom B
Thu May 31 00:00:00 EDT 2012
RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.
Blood
Baudet A,Karlsson C,Safaee Talkhoncheh M,Galeev R,Magnusson M,Larsson J
Thu Jun 28 00:00:00 EDT 2012
Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.
Blood
Williams AB,Li L,Nguyen B,Brown P,Levis M,Small D
Thu Oct 11 00:00:00 EDT 2012
Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.
Blood
Williams AB,Li L,Nguyen B,Brown P,Levis M,Small D
Thu Oct 11 00:00:00 EDT 2012
Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.
The Journal of clinical investigation
Cesana D,Sgualdino J,Rudilosso L,Merella S,Naldini L,Montini E
Tue May 01 00:00:00 EDT 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
The Journal of experimental medicine
Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H
Mon Oct 22 00:00:00 EDT 2012
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.
Proceedings of the National Academy of Sciences of the United States of America
Roy A,Cowan G,Mead AJ,Filippi S,Bohn G,Chaidos A,Tunstall O,Chan JK,Choolani M,Bennett P,Kumar S,Atkinson D,Wyatt-Ashmead J,Hu M,Stumpf MP,Goudevenou K,O'Connor D,Chou ST,Weiss MJ,Karadimitris A,Jacobsen SE,Vyas P,Roberts I
Tue Oct 23 00:00:00 EDT 2012
Intercellular cytosolic transfer correlates with mesenchymal stromal cell rescue of umbilical cord blood cell viability during ex vivo expansion.
Cytotherapy
Chu PP,Bari S,Fan X,Gay FP,Ang JM,Chiu GN,Lim SK,Hwang WY
Mon Oct 01 00:00:00 EDT 2012
Induced transgene expression for the treatment of solid tumors by hematopoietic stem cell-based gene therapy.
Cancer gene therapy
Noyan F,Díez IA,Hapke M,Klein C,Dewey RA
Tue May 01 00:00:00 EDT 2012
Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice.
Stem cells (Dayton, Ohio)
Reimann C,Six E,Dal-Cortivo L,Schiavo A,Appourchaux K,Lagresle-Peyrou C,de Chappedelaine C,Ternaux B,Coulombel L,Beldjord K,Cavazzana-Calvo M,Andre-Schmutz I
Wed Aug 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
A GpC-rich oligonucleotide acts on plasmacytoid dendritic cells to promote immune suppression.
Journal of immunology (Baltimore, Md. : 1950)
Volpi C,Fallarino F,Bianchi R,Orabona C,De Luca A,Vacca C,Romani L,Gran B,Grohmann U,Puccetti P,Belladonna ML
Sat Sep 01 00:00:00 EDT 2012
Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.
Cell communication and signaling : CCS
Arora D,Köthe S,van den Eijnden M,Hooft van Huijsduijnen R,Heidel F,Fischer T,Scholl S,Tölle B,Böhmer SA,Lennartsson J,Isken F,Müller-Tidow C,Böhmer FD
Wed Jul 11 00:00:00 EDT 2012
Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities.
PloS one
Aggarwal R,Lu J,Kanji S,Joseph M,Das M,Noble GJ,McMichael BK,Agarwal S,Hart RT,Sun Z,Lee BS,Rosol TJ,Jackson R,Mao HQ,Pompili VJ,Das H
Wed Dec 12 00:00:00 EST 2012
Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.
PloS one
Danova-Alt R,Heider A,Egger D,Cross M,Alt R
Tue Aug 07 00:00:00 EDT 2012
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
PloS one
Pelosi E,Castelli G,Martin-Padura I,Bordoni V,Santoro S,Conigliaro A,Cerio AM,De Santis Puzzonia M,Marighetti P,Biffoni M,Alonzi T,Amicone L,Alcalay M,Bertolini F,Testa U,Tripodi M
Tue May 21 00:00:00 EDT 2013
Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors.
PloS one
Ramos-Mejía V,Montes R,Bueno C,Ayllón V,Real PJ,Rodríguez R,Menendez P
Mon Aug 27 00:00:00 EDT 2012
Inhibition of Mammalian target of rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress.
Bone marrow research
Ryningen A,Reikvam H,Nepstad I,Paulsen Rye K,Bruserud O
Mon Oct 22 00:00:00 EDT 2012
Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.
BMC immunology
Patel ES,Okada S,Hachey K,Yang LJ,Durum SK,Moreb JS,Chang LJ
Thu Aug 16 00:00:00 EDT 2012
Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.
BMC immunology
Patel ES,Okada S,Hachey K,Yang LJ,Durum SK,Moreb JS,Chang LJ
Thu Aug 16 00:00:00 EDT 2012
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.
The Journal of biological chemistry
Yang T,Jian W,Luo Y,Fu X,Noguchi C,Bungert J,Huang S,Qiu Y
Fri Nov 23 00:00:00 EST 2012
Direct chromatin PCR (DC-PCR): hypotonic conditions allow differentiation of chromatin states during thermal cycling.
PloS one
Vatolin S,Khan SN,Reu FJ
Tue Mar 12 00:00:00 EDT 2013
Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion.
PloS one
Sangeetha VM,Kadekar D,Kale VP,Limaye LS
Mon May 14 00:00:00 EDT 2012
Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.
The Journal of biological chemistry
Gao H,Wu X,Sun Y,Zhou S,Silberstein LE,Zhu Z
Fri Aug 24 00:00:00 EDT 2012
Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation.
PloS one
Li XH,Ha CT,Fu D,Xiao M
Thu May 09 00:00:00 EDT 2013
A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo.
PloS one
Dahlke C,Maul K,Christalla T,Walz N,Schult P,Stocking C,Grundhoff A
Wed May 22 00:00:00 EDT 2013
Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.
PloS one
Yamagata Y,Parietti V,Stockholm D,Corre G,Poinsignon C,Touleimat N,Delafoy D,Besse C,Tost J,Galy A,Paldi A
Wed Jul 24 00:00:00 EDT 2013
Systematic discovery of TLR signaling components delineates viral-sensing circuits.
Cell
Chevrier N,Mertins P,Artyomov MN,Shalek AK,Iannacone M,Ciaccio MF,Gat-Viks I,Tonti E,DeGrace MM,Clauser KR,Garber M,Eisenhaure TM,Yosef N,Robinson J,Sutton A,Andersen MS,Root DE,von Andrian U,Jones RB,Park H,Carr SA,Regev A,Amit I,Hacohen N
Fri Nov 11 00:00:00 EST 2011
Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.
Cancer cell
Goardon N,Marchi E,Atzberger A,Quek L,Schuh A,Soneji S,Woll P,Mead A,Alford KA,Rout R,Chaudhury S,Gilkes A,Knapper S,Beldjord K,Begum S,Rose S,Geddes N,Griffiths M,Standen G,Sternberg A,Cavenagh J,Hunter H,Bowen D,Killick S,Robinson L,Price A,Macintyre E,Virgo P,Burnett A,Craddock C,Enver T,Jacobsen SE,Porcher C,Vyas P
Tue Jan 18 00:00:00 EST 2011
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 EDT 2011
JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.
Cancer cell
Liu F,Zhao X,Perna F,Wang L,Koppikar P,Abdel-Wahab O,Harr MW,Levine RL,Xu H,Tefferi A,Deblasio A,Hatlen M,Menendez S,Nimer SD
Tue Feb 15 00:00:00 EST 2011
Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.
Blood
Maetzig T,Brugman MH,Bartels S,Heinz N,Kustikova OS,Modlich U,Li Z,Galla M,Schiedlmeier B,Schambach A,Baum C
Thu Mar 17 00:00:00 EDT 2011
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.
Blood
Gibbs KD,Gilbert PM,Sachs K,Zhao F,Blau HM,Weissman IL,Nolan GP,Majeti R
Thu Apr 21 00:00:00 EDT 2011
Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination.
Blood
Pospori C,Xue SA,Holler A,Voisine C,Perro M,King J,Fallah-Arani F,Flutter B,Chakraverty R,Stauss HJ,Morris EC
Thu Jun 23 00:00:00 EDT 2011
Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.
Blood
Montes R,Ayllón V,Gutierrez-Aranda I,Prat I,Hernández-Lamas MC,Ponce L,Bresolin S,Te Kronnie G,Greaves M,Bueno C,Menendez P
Thu May 05 00:00:00 EDT 2011
Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.
Blood
Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ
Thu Mar 17 00:00:00 EDT 2011
Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.
Blood
Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ
Thu Feb 03 00:00:00 EST 2011
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Blood
Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE
Thu Sep 29 00:00:00 EDT 2011
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.
Blood
Bouma G,Mendoza-Naranjo A,Blundell MP,de Falco E,Parsley KL,Burns SO,Thrasher AJ
Thu Sep 01 00:00:00 EDT 2011
Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors.
Blood
Bonetti MI,Pieri L,Domenici L,Urbani S,Romano G,Aldinucci A,Ballerini C,Monici M,Saccardi R,Basile V,Bosi A,Romagnoli P
Thu Apr 14 00:00:00 EDT 2011
Sox6 enhances erythroid differentiation in human erythroid progenitors.
Blood
Cantù C,Ierardi R,Alborelli I,Fugazza C,Cassinelli L,Piconese S,Bosè F,Ottolenghi S,Ferrari G,Ronchi A
Thu Mar 31 00:00:00 EDT 2011
Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells.
Blood
Hu K,Yu J,Suknuntha K,Tian S,Montgomery K,Choi KD,Stewart R,Thomson JA,Slukvin II
Thu Apr 07 00:00:00 EDT 2011
Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow.
Blood
Matthes T,Dunand-Sauthier I,Santiago-Raber ML,Krause KH,Donze O,Passweg J,McKee T,Huard B
Thu Aug 18 00:00:00 EDT 2011
Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.
Blood
Klimchenko O,Di Stefano A,Geoerger B,Hamidi S,Opolon P,Robert T,Routhier M,El-Benna J,Delezoide AL,Boukour S,Lescure B,Solary E,Vainchenker W,Norol F
Thu Mar 17 00:00:00 EDT 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 EDT 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
300-19 was used in Cell Culture to study how differentiation of myeloid progenitors into mature myeloid cells requires an additional 5-19 d of culture with cytokines, depending on the cell type.
Tue Mar 01 00:00:00 EST 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
300-19 was used in Cell Culture to study how differentiation of myeloid progenitors into mature myeloid cells requires an additional 5-19 d of culture with cytokines, depending on the cell type.
Tue Mar 01 00:00:00 EST 2011
Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Feng N,Vegh P,Rothenberg EV,Yui MA
Sat Jan 15 00:00:00 EST 2011
The Role of Plasmacytoid and Myeloid Dendritic Cells in Induction of Asthma in a Mouse Model and the Effect of a TLR9 Agonist on Dendritic Cells.
Allergy, asthma & immunology research
Mo JH,Chung YJ,Hayashi T,Lee J,Raz E
Fri Jul 01 00:00:00 EDT 2011
Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors.
PloS one
Mack AA,Kroboth S,Rajesh D,Wang WB
Mon Apr 02 00:00:00 EDT 2012
Hypoxia selects bortezomib-resistant stem cells of chronic myeloid leukemia.
PloS one
Tanturli M,Giuntoli S,Barbetti V,Rovida E,Dello Sbarba P
Fri Feb 11 00:00:00 EST 2011
Generation of bivalent chromatin domains during cell fate decisions.
Epigenetics & chromatin
De Gobbi M,Garrick D,Lynch M,Vernimmen D,Hughes JR,Goardon N,Luc S,Lower KM,Sloane-Stanley JA,Pina C,Soneji S,Renella R,Enver T,Taylor S,Jacobsen SE,Vyas P,Gibbons RJ,Higgs DR
Mon Jun 06 00:00:00 EDT 2011
Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells.
PloS one
Sjeklocha LM,Park CW,Wong PY,Roney MJ,Belcher JD,Kaufman DS,Vercellotti GM,Hebbel RP,Steer CJ
Mon May 21 00:00:00 EDT 2012
Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia.
Blood cancer journal
Skavland J,Jørgensen KM,Hadziavdic K,Hovland R,Jonassen I,Bruserud O,Gjertsen BT
Tue Feb 01 00:00:00 EST 2011
Comparative study of hematopoietic differentiation between human embryonic stem cell lines.
PloS one
Melichar H,Li O,Ross J,Haber H,Cado D,Nolla H,Robey EA,Winoto A
Fri Oct 21 00:00:00 EDT 2011
Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
The Journal of biological chemistry
Sarma NJ,Yaseen NR
Fri Nov 11 00:00:00 EST 2011
Efficient feeder-free episomal reprogramming with small molecules.
PloS one
Yu J,Chau KF,Vodyanik MA,Jiang J,Jiang Y
Tue Mar 01 00:00:00 EST 2011
Magnetic resonance imaging of bone marrow cell-mediated interleukin-10 gene therapy of atherosclerosis.
PloS one
Sun J,Li X,Feng H,Gu H,Blair T,Li J,Soriano S,Meng Y,Zhang F,Feng Q,Yang X
Tue Feb 14 00:00:00 EST 2012
Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.
The Journal of biological chemistry
Nishimura K,Sano M,Ohtaka M,Furuta B,Umemura Y,Nakajima Y,Ikehara Y,Kobayashi T,Segawa H,Takayasu S,Sato H,Motomura K,Uchida E,Kanayasu-Toyoda T,Asashima M,Nakauchi H,Yamaguchi T,Nakanishi M
Fri Feb 11 00:00:00 EST 2011
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
The Journal of biological chemistry
Arora D,Stopp S,Böhmer SA,Schons J,Godfrey R,Masson K,Razumovskaya E,Rönnstrand L,Tänzer S,Bauer R,Böhmer FD,Müller JP
Fri Apr 01 00:00:00 EDT 2011
Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase.
PloS one
Nishino T,Wang C,Mochizuki-Kashio M,Osawa M,Nakauchi H,Iwama A
Mon Jan 30 00:00:00 EST 2012
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.
Immunity
Hughes T,Becknell B,Freud AG,McClory S,Briercheck E,Yu J,Mao C,Giovenzana C,Nuovo G,Wei L,Zhang X,Gavrilin MA,Wewers MD,Caligiuri MA
Fri Jun 25 00:00:00 EDT 2010
W41/W41 blastocyst complementation: a system for genetic modeling of hematopoiesis.
Blood
Jansson L,Larsson J
Thu Jan 07 00:00:00 EST 2010
Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.
Blood
Agerstam H,Järås M,Andersson A,Johnels P,Hansen N,Lassen C,Rissler M,Gisselsson D,Olofsson T,Richter J,Fan X,Ehinger M,Fioretos T
Thu Sep 23 00:00:00 EDT 2010
Iron control of erythroid development by a novel aconitase-associated regulatory pathway.
Blood
Bullock GC,Delehanty LL,Talbot AL,Gonias SL,Tong WH,Rouault TA,Dewar B,Macdonald JM,Chruma JJ,Goldfarb AN
Thu Jul 08 00:00:00 EDT 2010
Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors.
Blood
Yu C,Liu Y,Miao Z,Yin M,Lu W,Lv Y,Ding M,Deng H
Thu Dec 02 00:00:00 EST 2010
Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential.
Blood
Grassinger J,Haylock DN,Williams B,Olsen GH,Nilsson SK
Thu Oct 28 00:00:00 EDT 2010
Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera.
Blood
Perna F,Gurvich N,Hoya-Arias R,Abdel-Wahab O,Levine RL,Asai T,Voza F,Menendez S,Wang L,Liu F,Zhao X,Nimer SD
Thu Oct 14 00:00:00 EDT 2010
Sulfatase modifying factor 1-mediated fibroblast growth factor signaling primes hematopoietic multilineage development.
The Journal of experimental medicine
Buono M,Visigalli I,Bergamasco R,Biffi A,Cosma MP
Mon Aug 02 00:00:00 EDT 2010
MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity.
The Journal of experimental medicine
Irla M,Küpfer N,Suter T,Lissilaa R,Benkhoucha M,Skupsky J,Lalive PH,Fontana A,Reith W,Hugues S
Mon Aug 30 00:00:00 EDT 2010
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
The Journal of experimental medicine
Takayama N,Nishimura S,Nakamura S,Shimizu T,Ohnishi R,Endo H,Yamaguchi T,Otsu M,Nishimura K,Nakanishi M,Sawaguchi A,Nagai R,Takahashi K,Yamanaka S,Nakauchi H,Eto K
Mon Dec 20 00:00:00 EST 2010
Mouse mesenchymal stem cells can support human hematopoiesis both in vitro and in vivo: the crucial role of neural cell adhesion molecule.
Haematologica
Wang X,Hisha H,Mizokami T,Cui W,Cui Y,Shi A,Song C,Okazaki S,Li Q,Feng W,Kato J,Ikehara S
300-19 was used in Cell Culture to investigate the role of MSC surface molecules in the regulation of haematopoiesis.
Tue Jun 01 00:00:00 EDT 2010
Cyclin C regulates human hematopoietic stem/progenitor cell quiescence.
Stem cells (Dayton, Ohio)
Miyata Y,Liu Y,Jankovic V,Sashida G,Lee JM,Shieh JH,Naoe T,Moore M,Nimer SD
Mon Feb 01 00:00:00 EST 2010
The retinoid signaling pathway inhibits hematopoiesis and uncouples from the Hox genes during hematopoietic development.
Stem cells (Dayton, Ohio)
Szatmari I,Iacovino M,Kyba M
Wed Sep 01 00:00:00 EDT 2010
Fine-scale staging of T cell lineage commitment in adult mouse thymus.
Journal of immunology (Baltimore, Md. : 1950)
Yui MA,Feng N,Rothenberg EV
Thu Jul 01 00:00:00 EDT 2010
Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice.
Journal of immunology (Baltimore, Md. : 1950)
Reboulet RA,Hennies CM,Garcia Z,Nierkens S,Janssen EM
Wed Sep 15 00:00:00 EDT 2010
Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling.
Journal of immunology (Baltimore, Md. : 1950)
van de Laar L,Buitenhuis M,Wensveen FM,Janssen HL,Coffer PJ,Woltman AM
Tue Jun 15 00:00:00 EDT 2010
Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.
Journal of immunology (Baltimore, Md. : 1950)
Lee SH,Yun S,Piao ZH,Jeong M,Kim DO,Jung H,Lee J,Kim MJ,Kim MS,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I
Thu Jul 15 00:00:00 EDT 2010
CXCR7 protein is not expressed on human or mouse leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ
Mon Nov 01 00:00:00 EDT 2010
CXCR7 protein is not expressed on human or mouse leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Berahovich RD,Zabel BA,Penfold ME,Lewén S,Wang Y,Miao Z,Gan L,Pereda J,Dias J,Slukvin II,McGrath KE,Jaen JC,Schall TJ
Mon Nov 01 00:00:00 EDT 2010
Hoxa9 regulates Flt3 in lymphohematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Gwin K,Frank E,Bossou A,Medina KL
Wed Dec 01 00:00:00 EST 2010
miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.
Journal of immunology (Baltimore, Md. : 1950)
Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H
Sat May 01 00:00:00 EDT 2010
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
BMC immunology
Ersvaer E,Liseth K,Skavland J,Gjertsen BT,Bruserud Ø
Fri Jul 09 00:00:00 EDT 2010
Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.
The Journal of biological chemistry
Chang YI,Hua WK,Yao CL,Hwang SM,Hung YC,Kuan CJ,Leou JS,Lin WJ
Fri Jul 02 00:00:00 EDT 2010
Expansion of cord blood CD34 cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse.
PloS one
V M S,Kale VP,Limaye LS
Tue Aug 17 00:00:00 EDT 2010
Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2.
Nature protocols
Giorgetti A,Montserrat N,Rodriguez-Piza I,Azqueta C,Veiga A,Izpisúa Belmonte JC
Thu Apr 01 00:00:00 EDT 2010
In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML.
PloS one
Abdul-Nabi AM,Yassin ER,Varghese N,Deshmukh H,Yaseen NR
Fri Aug 27 00:00:00 EDT 2010
Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states.
BMC systems biology
Felli N,Cianetti L,Pelosi E,Carè A,Liu CG,Calin GA,Rossi S,Peschle C,Marziali G,Giuliani A
Wed Jun 16 00:00:00 EDT 2010
Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.
Immunity
Lauritsen JP,Wong GW,Lee SY,Lefebvre JM,Ciofani M,Rhodes M,Kappes DJ,Zúñiga-Pflücker JC,Wiest DL
Fri Oct 16 00:00:00 EDT 2009
Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.
Nature immunology
Ilarregui JM,Croci DO,Bianco GA,Toscano MA,Salatino M,Vermeulen ME,Geffner JR,Rabinovich GA
Tue Sep 01 00:00:00 EDT 2009
Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML.
Blood
Zhou J,Bi C,Janakakumara JV,Liu SC,Chng WJ,Tay KG,Poon LF,Xie Z,Palaniyandi S,Yu H,Glaser KB,Albert DH,Davidsen SK,Chen CS
Thu Apr 23 00:00:00 EDT 2009
The F12-Vif derivative Chim3 inhibits HIV-1 replication in CD4+ T lymphocytes and CD34+-derived macrophages by blocking HIV-1 DNA integration.
Blood
Porcellini S,Alberici L,Gubinelli F,Lupo R,Olgiati C,Rizzardi GP,Bovolenta C
Thu Apr 09 00:00:00 EDT 2009
Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity.
Blood
Woll PS,Grzywacz B,Tian X,Marcus RK,Knorr DA,Verneris MR,Kaufman DS
Thu Jun 11 00:00:00 EDT 2009
Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome.
Blood
Will B,Kawahara M,Luciano JP,Bruns I,Parekh S,Erickson-Miller CL,Aivado MA,Verma A,Steidl U
Thu Oct 29 00:00:00 EDT 2009
BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.
Blood
Nordigården A,Kraft M,Eliasson P,Labi V,Lam EW,Villunger A,Jönsson JI
Thu Mar 05 00:00:00 EST 2009
AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms.
Blood
Ding Y,Harada Y,Imagawa J,Kimura A,Harada H
Thu Dec 10 00:00:00 EST 2009
Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.
Blood
McKinney-Freeman SL,Naveiras O,Yates F,Loewer S,Philitas M,Curran M,Park PJ,Daley GQ
Thu Jul 09 00:00:00 EDT 2009
E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.
Blood
Bandi SR,Brandts C,Rensinghoff M,Grundler R,Tickenbrock L,Köhler G,Duyster J,Berdel WE,Müller-Tidow C,Serve H,Sargin B
Thu Nov 05 00:00:00 EST 2009
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.
Blood
Xue X,Huang X,Nodland SE,Mátés L,Ma L,Izsvák Z,Ivics Z,LeBien TW,McIvor RS,Wagner JE,Zhou X
Thu Aug 13 00:00:00 EDT 2009
Role for MKL1 in megakaryocytic maturation.
Blood
Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS
Thu Mar 19 00:00:00 EDT 2009
Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib.
Blood
Yong AS,Keyvanfar K,Hensel N,Eniafe R,Savani BN,Berg M,Lundqvist A,Adams S,Sloand EM,Goldman JM,Childs R,Barrett AJ
Thu Jan 22 00:00:00 EST 2009
Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.
Blood
Kandilci A,Grosveld GC
Thu Aug 20 00:00:00 EDT 2009
Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.
Blood
Awong G,Herer E,Surh CD,Dick JE,La Motte-Mohs RN,Zúñiga-Pflücker JC
Thu Jul 30 00:00:00 EDT 2009
Generation of induced pluripotent stem cells from human blood.
Blood
Loh YH,Agarwal S,Park IH,Urbach A,Huo H,Heffner GC,Kim K,Miller JD,Ng K,Daley GQ
Thu May 28 00:00:00 EDT 2009
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood
Eberhard Y,McDermott SP,Wang X,Gronda M,Venugopal A,Wood TE,Hurren R,Datti A,Batey RA,Wrana J,Antholine WE,Dick JE,Schimmer AD
Thu Oct 01 00:00:00 EDT 2009
The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.
The Journal of clinical investigation
Ford AM,Palmi C,Bueno C,Hong D,Cardus P,Knight D,Cazzaniga G,Enver T,Greaves M
Wed Apr 01 00:00:00 EDT 2009
Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function.
The Journal of experimental medicine
la Sala A,He J,Laricchia-Robbio L,Gorini S,Iwasaki A,Braun M,Yap GS,Sher A,Ozato K,Kelsall B
Mon Jun 08 00:00:00 EDT 2009
MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.
The EMBO journal
Schwermann J,Rathinam C,Schubert M,Schumacher S,Noyan F,Koseki H,Kotlyarov A,Klein C,Gaestel M
Wed May 20 00:00:00 EDT 2009
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy
Modlich U,Navarro S,Zychlinski D,Maetzig T,Knoess S,Brugman MH,Schambach A,Charrier S,Galy A,Thrasher AJ,Bueren J,Baum C
Sun Nov 01 00:00:00 EDT 2009
Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds.
Stem cells (Dayton, Ohio)
Compte M,Cuesta AM,Sánchez-Martín D,Alonso-Camino V,Vicario JL,Sanz L,Alvarez-Vallina L
Sun Mar 01 00:00:00 EST 2009
Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.
Stem cells (Dayton, Ohio)
Tian X,Hexum MK,Penchev VR,Taylor RJ,Shultz LD,Kaufman DS
Sun Nov 01 00:00:00 EDT 2009
A feeder-free and efficient production of functional neutrophils from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Saeki K,Saeki K,Nakahara M,Matsuyama S,Nakamura N,Yogiashi Y,Yoneda A,Koyanagi M,Kondo Y,Yuo A
Thu Jan 01 00:00:00 EST 2009
IL-7 enhances thymic human T cell development in "human immune system" Rag2-/-IL-2Rgammac-/- mice without affecting peripheral T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
van Lent AU,Dontje W,Nagasawa M,Siamari R,Bakker AQ,Pouw SM,Maijoor KA,Weijer K,Cornelissen JJ,Blom B,Di Santo JP,Spits H,Legrand N
Tue Dec 15 00:00:00 EST 2009
The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells.
Journal of immunology (Baltimore, Md. : 1950)
Boehmler AM,Drost A,Jaggy L,Seitz G,Wiesner T,Denzlinger C,Kanz L,Möhle R
Mon Jun 01 00:00:00 EDT 2009
Generation of T cells from human embryonic stem cell-derived hematopoietic zones.
Journal of immunology (Baltimore, Md. : 1950)
Timmermans F,Velghe I,Vanwalleghem L,De Smedt M,Van Coppernolle S,Taghon T,Moore HD,Leclercq G,Langerak AW,Kerre T,Plum J,Vandekerckhove B
Mon Jun 01 00:00:00 EDT 2009
RasGRP1 is required for human NK cell function.
Journal of immunology (Baltimore, Md. : 1950)
Lee SH,Yun S,Lee J,Kim MJ,Piao ZH,Jeong M,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I
Tue Dec 15 00:00:00 EST 2009
Kinetics and effect of integrin expression on human CD34(+) cells during murine leukemia virus-derived retroviral transduction with recombinant fibronectin for stem cell gene therapy.
Human gene therapy
Horiuchi Y,Onodera M,Miyagawa Y,Sato B,Onda K,Katagiri YU,Okita H,Okada M,Otsu M,Kume A,Okuyama T,Fujimoto J,Kuratsuji T,Kiyokawa N
Wed Jul 01 00:00:00 EDT 2009
FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells.
The Journal of biological chemistry
Fukushima K,Matsumura I,Ezoe S,Tokunaga M,Yasumi M,Satoh Y,Shibayama H,Tanaka H,Iwama A,Kanakura Y
Fri Mar 20 00:00:00 EDT 2009
Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model.
PloS one
Das H,George JC,Joseph M,Das M,Abdulhameed N,Blitz A,Khan M,Sakthivel R,Mao HQ,Hoit BD,Kuppusamy P,Pompili VJ
Wed Oct 07 00:00:00 EDT 2009
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.
PloS one
Robert G,Ben Sahra I,Puissant A,Colosetti P,Belhacene N,Gounon P,Hofman P,Bost F,Cassuto JP,Auberger P
Wed Nov 18 00:00:00 EST 2009
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
Cell
Cisse B,Caton ML,Lehner M,Maeda T,Scheu S,Locksley R,Holmberg D,Zweier C,den Hollander NS,Kant SG,Holter W,Rauch A,Zhuang Y,Reizis B
Fri Oct 03 00:00:00 EDT 2008
Interleukin-27 directly induces differentiation in hematopoietic stem cells.
Blood
Seita J,Asakawa M,Ooehara J,Takayanagi S,Morita Y,Watanabe N,Fujita K,Kudo M,Mizuguchi J,Ema H,Nakauchi H,Yoshimoto T
Fri Feb 15 00:00:00 EST 2008
Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.
Clinical cancer research : an official journal of the American Association for Cancer Research
Su Z,Frye C,Bae KM,Kelley V,Vieweg J
Wed Oct 01 00:00:00 EDT 2008
CD4 cell-secreted, posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production.
Proceedings of the National Academy of Sciences of the United States of America
Kim-Saijo M,Janssen EM,Sugie K
Tue Dec 09 00:00:00 EST 2008
Identification of a small subpopulation of candidate leukemia-initiating cells in the side population of patients with acute myeloid leukemia.
Stem cells (Dayton, Ohio)
Moshaver B,van Rhenen A,Kelder A,van der Pol M,Terwijn M,Bachas C,Westra AH,Ossenkoppele GJ,Zweegman S,Schuurhuis GJ
Mon Dec 01 00:00:00 EST 2008
Ikaros regulates Notch target gene expression in developing thymocytes.
Journal of immunology (Baltimore, Md. : 1950)
Chari S,Winandy S
Sat Nov 01 00:00:00 EDT 2008
Cerebrospinal fluid dendritic cells infiltrate the brain parenchyma and target the cervical lymph nodes under neuroinflammatory conditions.
PloS one
Hatterer E,Touret M,Belin MF,Honnorat J,Nataf S
Thu Oct 02 00:00:00 EDT 2008
Are interleukin-16 and thrombopoietin new tools for the in vitro generation of dendritic cells?
Blood
Della Bella S,Nicola S,Timofeeva I,Villa ML,Santoro A,Berardi AC
Wed Dec 15 00:00:00 EST 2004
Induction of potent antitumor immunity by in situ targeting of intratumoral DCs.
The Journal of clinical investigation
Furumoto K,Soares L,Engleman EG,Merad M
Mon Mar 01 00:00:00 EST 2004
Isolation, growth and identification of colony-forming cells with erythroid, myeloid, dendritic cell and NK-cell potential from human fetal liver.
Biological procedures online
Muench MO,Suskind DL,Bárcena A
300-19 was used in Cell Culture to describe a method for the isolation from human fetal liver of highly purified candidate HSCs and progenitors based on the phenotypes CD38(-)CD34(++) and CD38(+)CD34(++), respectively.
Tue Jun 11 00:00:00 EDT 2002
IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Stober D,Schirmbeck R,Reimann J
300-19 was used in Cell Culture to study how dendritic cells (DCs) are a source of early IFN-gamma generated in response to a cascade of cytokine- and/or cell derived signals that can be positively and negatively regulated.
Sun Jul 15 00:00:00 EDT 2001