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Highest antigen sequence indentity to the following orthologs: Mouse (73%), Rat (73%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66608. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADP-ribosylation factor-binding protein GGA2; gam; Gamma-adaptin-related protein 2; golgi-associated, gamma adaptin ear containing, ARF binding protein 2; Golgi-localized, gamma ear-containing, ARF-binding protein 2; Vear; VHS domain and ear domain of gamma-adaptin; VHS domain and ear domain-containing protein
Gene Aliases: GGA2; KIAA1080; VEAR
UniProt ID: (Human) Q9UJY4
Entrez Gene ID: (Human) 23062
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