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PEP-153 is a 15 amino acid synthetic peptide whose sequences are derived from human Tr alpha protein. The sequence of this peptide is (amino to carboxy terminus): K (18)-L-K-E-D-A- E-K-D-A-R-T-V-K (31)-C
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human Tr alpha, catalog # PA1-724. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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