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Invitrogen
Human HTRA1 Recombinant Protein
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Product Details
RP-77541
Product Specifications
Expression System
E. coli
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
5 µg
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
RP-77541 is a truncated, recombinant human HtrA1 protein expressed in E. coli; amino acids 141-480 of full-length HtrA1 with a C-terminal 6x His-tag,containing the catalytic and PDZ domain.
RP-77541 may be used as a control with corresponding anti-HtrA1 antibodies or in an enzymatic assay. RP-77541 appears as a major protein of about 37 kDa in SDS-PAGE.
Target Information
HtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus. It plays a major role in the regulation of cell growth. HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes. HtrA1 is up-regulated in placenta during pregnancy and plays an important role in implantation and placental physiology. It regulates the availability of IGFs by cleaving IGF-binding proteins. It acts as a tumor suppressor and is down-regulated in ovarian cancers and melanomas. Its role has been implicated in osteoarthritis suggesting a therapeutic intervention. Northern blot analysis detected high expression in placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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