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Product Details
PHC4244
Product Specifications
Species
Human
Expression System
CHO cells
Molecular weight
23 kDa
Class
Recombinant
Type
Protein
Purity
>95%
Endotoxin concentration
<1 EU/µg
Activity
EC50 ~ 1 U/mL; determined by a cytopathic inhibition assay on human A549 lung carcinoma cells with encephalomyocarditis virus (EMCV).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
purified
Storage buffer
50mM sodium acetate with 0.1% BSA
Contains
no preservative
Storage conditions
-80°C
Shipping conditions
Dry ice
Product Specific Information
Source: cDNA obtained from human fibroblast interferon beta 1a mRNA expressed in CHO cells.
Storage: After receipt, the product may be stored at -20°C for short-term use (<6 months). For long-term storage, store the product at -70°C or below for retention of full activity. Thaw product vial by incubation in cold tap water until just thawed. The contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).
Target Information
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta 1; fibroblast interferon; IFN-beta; Interferon; Interferon beta-1a; interferon, beta 1, fibroblast; interferon-beta; unnamed protein product
Gene Aliases: IFB; IFF; IFN-beta; IFNB
UniProt ID: (Human) P01574
Entrez Gene ID: (Human) 3456
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