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This peptide corresponds to 16 amino acids near the carboxy terminus of human IKAP.
PEP-0404 can be used as a blocking peptide with polyclonal antibody PA5-20286.
The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia.
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Protein Aliases: DKFZp781H1425; elongator acetyltransferase complex subunit 1; Elongator complex protein 1; ELP1; FLJ12497; IkappaB kinase complex-associated protein; IKK complex-associated protein; p150; RP11-3J11.4
Gene Aliases: DYS; ELP1; FD; IKAP; IKBKAP; IKI3; TOT1
UniProt ID: (Human) O95163
Entrez Gene ID: (Human) 8518
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