Product References
Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.
Developmental cell
Fowler JL,Zheng SL,Nguyen A,Chen A,Xiong X,Chai T,Chen JY,Karigane D,Banuelos AM,Niizuma K,Kayamori K,Nishimura T,Cromer MK,Gonzalez-Perez D,Mason C,Liu DD,Yilmaz L,Miquerol L,Porteus MH,Luca VC,Majeti R,Nakauchi H,Red-Horse K,Weissman IL,Ang LT,Loh KM
200-07 was used in Cell Culture to non-invasive genetic lineage tracing in mouse embryos pinpoints that artery endothelial cells generate hematopoietic stem cells.
Mon May 06 00:00:00 EDT 2024
Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells.
Cell reports. Medicine
Albanese M,Chen HR,Gapp M,Muenchhoff M,Yang HH,Peterhoff D,Hoffmann K,Xiao Q,Ruhle A,Ambiel I,Schneider S,Mejías-Pérez E,Stern M,Wratil PR,Hofmann K,Amann L,Jocham L,Fuchs T,Ulivi AF,Besson-Girard S,Weidlich S,Schneider J,Spinner CD,Sutter K,Dittmer U,Humpe A,Baumeister P,Wieser A,Rothenfusser S,Bogner J,Roider J,Knolle P,Hengel H,Wagner R,Laketa V,Fackler OT,Keppler OT
200-07 was used in Cell Culture to report that surface receptors can be transferred from primary macrophages to CD4 T cells and identify the Fcγ receptor CD32 as driver and cargo of this trogocytotic transfer.
Tue Apr 16 00:00:00 EDT 2024
Decoding human bone marrow hematopoietic stem and progenitor cells from fetal to birth.
iScience
Xie X,Gou F,Zheng Z,Zhang Y,Zhang Y,Dong F,Cheng T,Cheng H
200-07 was used in Cell Culture to elucidate the dynamics of fetal hematopoiesis in preparation for birth, offering valuable insights into the pathological processes underlying leukemia.
Fri Aug 16 00:00:00 EDT 2024
Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.
British journal of haematology
Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y
200-07 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.
Sat Jul 01 00:00:00 EDT 2023
Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis.
Nature communications
Moon JS,Younis S,Ramadoss NS,Iyer R,Sheth K,Sharpe O,Rao NL,Becart S,Carman JA,James EA,Buckner JH,Deane KD,Holers VM,Goodman SM,Donlin LT,Davis MM,Robinson WH
200-07 was used in In vitro experiments to suggest that cytotoxic CD8+ T cells targeting citrullinated antigens contribute to synovitis and joint tissue destruction in ACPA+ RA.
Thu Jan 19 00:00:00 EST 2023
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia.
Nature
Casirati G,Cosentino A,Mucci A,Salah Mahmoud M,Ugarte Zabala I,Zeng J,Ficarro SB,Klatt D,Brendel C,Rambaldi A,Ritz J,Marto JA,Pellin D,Bauer DE,Armstrong SA,Genovese P
200-07 was used in Cell Culture to show that multiplex epitope engineering of haematopoietic stem/progenitor cells is feasible and enables more effective immunotherapies against multiple targets without incurring overlapping off-tumour toxicities.
Fri Sep 01 00:00:00 EDT 2023
Durable remission related to CAR-T persistence in R/R B-ALL and long-term persistence potential of prime CAR-T.
Molecular therapy oncolytics
Shiqi L,Jiasi Z,Lvzhe C,Huailong X,Liping H,Lin L,Qianzhen Z,Zhongtao Y,Junjie S,Zucong C,Yingzi Z,Meiling W,Yunyan L,Linling W,Lihua F,Yingnian C,Wei Z,Yu L,Le L,Youcheng W,Dingsong Z,Yancheng D,Ping Y,Lihua Z,Xiaoping L,Xiaozhuang H,Zhongzheng Z,Zhi Y,Cheng Q,Sanbin W
200-07 was used in Cell Culture to find only that CAR-T persistence was highly correlated with patients' long-term disease-free survival.
Thu Jun 15 00:00:00 EDT 2023
SOX18-enforced expression diverts hemogenic endothelium-derived progenitors from T towards NK lymphoid pathways.
iScience
Jung HS,Suknuntha K,Kim YH,Liu P,Dettle ST,Sedzro DM,Smith PR,Thomson JA,Ong IM,Slukvin II
200-07 was used in In vitro experiments to reveal that SOX18 forced expression at the mesodermal stage, in contrast to its homolog SOX17, has minimal effects on arterial specification of hemogenic endothelium, expression of HOXA genes and lymphoid differentiation.
Fri May 19 00:00:00 EDT 2023
IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia.
EMBO molecular medicine
Liu X,Sato N,Yabushita T,Li J,Jia Y,Tamura M,Asada S,Fujino T,Fukushima T,Yonezawa T,Tanaka Y,Fukuyama T,Tsuchiya A,Shikata S,Iwamura H,Kinouchi C,Komatsu K,Yamasaki S,Shibata T,Sasaki AT,Schibler J,Wunderlich M,O'Brien E,Mizukawa B,Mulloy JC,Sugiura Y,Takizawa H,Shibata T,Miyake K,Kitamura T,Goyama S
200-07 was used in Cell Culture to provide a rational basis for clinical testing of Inosine monophosphate dehydrogenase inhibitors against MLL-fusion acute myeloid leukaemia's and potentially other aggressive tumours with active TLR signalling.
Wed Jan 11 00:00:00 EST 2023
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design.
iScience
Li YR,Ochoa CJ,Zhu Y,Kramer A,Wilson M,Fang Y,Chen Y,Singh T,Di Bernardo G,Zhu E,Lee D,Moatamed NA,Bando J,Zhou JJ,Memarzadeh S,Yang L
200-07 was used in Cell Culture to we conducted a comprehensive analysis of primary tumor cells and their microenvironment from 16 chemonaive and 10 recurrent ovarian cancer (OC) patient samples.
Fri Oct 20 00:00:00 EDT 2023
Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target.
Nature cancer
Mandal K,Wicaksono G,Yu C,Adams JJ,Hoopmann MR,Temple WC,Izgutdina A,Escobar BP,Gorelik M,Ihling CH,Nix MA,Naik A,Xie WH,Hübner J,Rollins LA,Reid SM,Ramos E,Kasap C,Steri V,Serrano JAC,Salangsang F,Phojanakong P,McMillan M,Gavallos V,Leavitt AD,Logan AC,Rooney CM,Eyquem J,Sinz A,Huang BJ,Stieglitz E,Smith CC,Moritz RL,Sidhu SS,Huang L,Wiita AP
200-07 was used in Cell Culture to develop and characterize recombinant antibodies to this protein conformation and show that chimeric antigen receptor T cells eliminate acute myeloid leukemia (AML) cells and patient-derived xenografts without notable toxicity toward normal hematopoietic cells.
Wed Nov 01 00:00:00 EDT 2023
Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target.
Nature cancer
Mandal K,Wicaksono G,Yu C,Adams JJ,Hoopmann MR,Temple WC,Izgutdina A,Escobar BP,Gorelik M,Ihling CH,Nix MA,Naik A,Xie WH,Hübner J,Rollins LA,Reid SM,Ramos E,Kasap C,Steri V,Serrano JAC,Salangsang F,Phojanakong P,McMillan M,Gavallos V,Leavitt AD,Logan AC,Rooney CM,Eyquem J,Sinz A,Huang BJ,Stieglitz E,Smith CC,Moritz RL,Sidhu SS,Huang L,Wiita AP
200-07 was used in Cell Culture to develop and characterize recombinant antibodies to this protein conformation and show that chimeric antigen receptor T cells eliminate acute myeloid leukemia (AML) cells and patient-derived xenografts without notable toxicity toward normal hematopoietic cells.
Wed Nov 01 00:00:00 EDT 2023
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins.
Cell
Banskota S,Raguram A,Suh S,Du SW,Davis JR,Choi EH,Wang X,Nielsen SC,Newby GA,Randolph PB,Osborn MJ,Musunuru K,Palczewski K,Liu DR
Thu Jan 20 00:00:00 EST 2022
Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses.
Nature methods
Albanese M,Ruhle A,Mittermaier J,Mejías-Pérez E,Gapp M,Linder A,Schmacke NA,Hofmann K,Hennrich AA,Levy DN,Humpe A,Conzelmann KK,Hornung V,Fackler OT,Keppler OT
Sat Jan 01 00:00:00 EST 2022
Angiotensin II enhances group 2 innate lymphoid cell responses via AT1a during airway inflammation.
The Journal of experimental medicine
Liu G,Chen Y,Wang Y,Deng X,Xiao Q,Zhang L,Xu H,Han X,Lei A,He J,Li X,Cao Y,Zhou P,He C,Wu P,Jiang W,Tan M,Chen C,Yang Q,Lu L,Deng K,Yao Z,Zhou J
Mon Mar 07 00:00:00 EST 2022
Disease-associated mutations in topoisomerase IIβ result in defective NK cells.
The Journal of allergy and clinical immunology
Broderick L,Clay GM,Blum RH,Liu Y,McVicar R,Papes F,Booshehri LM,Cowell IG,Austin CA,Putnam CD,Kaufman DS
200-07 was used in Cell Culture to support that Hoffman syndrome-associated mutations in TOP2B impact NK-cell development and function in murine and human models.
Wed Jun 01 00:00:00 EDT 2022
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.
EMBO reports
Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB
200-07 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.
Thu Feb 03 00:00:00 EST 2022
Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs.
Frontiers in cell and developmental biology
Lee M,Geitgey DK,Hamilton JAG,Boss JM,Scharer CD,Spangle JM,Haynes KA,Henry CJ
200-07 was used in Sample Preparation (FC/FACS) to investigate T-cell acute lymphoblastic leukemia relationship with obesity in murine models.
Wed Sep 07 00:00:00 EDT 2022
Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers.
iScience
Li YR,Zeng S,Dunn ZS,Zhou Y,Li Z,Yu J,Wang YC,Ku J,Cook N,Kramer A,Yang L
200-07 was used in In vitro experiments to report the successful generation of third-party HSC-engineered human iNKT (3rdHSC-iNKT) cells using a method combining HSC gene engineering and in vitro HSC differentiation.
Fri Sep 16 00:00:00 EDT 2022
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.
JCI insight
Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA
200-07 was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.
Wed Jun 08 00:00:00 EDT 2022
Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair.
STAR protocols
Moosmann C,Müller TR,Busch DH,Schober K
Fri Mar 18 00:00:00 EDT 2022
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers.
Immunity
Giles JR,Manne S,Freilich E,Oldridge DA,Baxter AE,George S,Chen Z,Huang H,Chilukuri L,Carberry M,Giles L,Weng NP,Young RM,June CH,Schuchter LM,Amaravadi RK,Xu X,Karakousis GC,Mitchell TC,Huang AC,Shi J,Wherry EJ
200-07 was used in In vitro experiments to define epigenetic and transcriptional regulation of human T cells and illustrate the utility of interrogating disease in the context of a healthy T cell atlas.
Tue Mar 08 00:00:00 EST 2022
Synergistic Therapeutic Effects of Low Dose Decitabine and NY-ESO-1 Specific TCR-T Cells for the Colorectal Cancer With Microsatellite Stability.
Frontiers in oncology
Yu G,Wang W,He X,Xu J,Xu R,Wan T,Wu Y
200-07 was used in Cell Culture to show that NY-ESO-1 TCR-T cell therapy could inhibit A375 tumor growth and prolonged the survival time.
Sat Jul 16 00:00:00 EDT 2022
BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia.
Cell death discovery
Parry N,Busch C,Aßmann V,Cassels J,Hair A,Helgason GV,Wheadon H,Copland M
200-07 was used in Cell Culture to suggest that BH3 mimetics represent an interesting avenue for further exploration in myeloid BP-CML, for which alternative treatment options are desperately sought.
Tue Nov 15 00:00:00 EST 2022
CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells.
Nature communications
Hebbar N,Epperly R,Vaidya A,Thanekar U,Moore SE,Umeda M,Ma J,Patil SL,Langfitt D,Huang S,Cheng C,Klco JM,Gottschalk S,Velasquez MP
Mon Jan 31 00:00:00 EST 2022
Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer.
Nature
Eberhardt CS,Kissick HT,Patel MR,Cardenas MA,Prokhnevska N,Obeng RC,Nasti TH,Griffith CC,Im SJ,Wang X,Shin DM,Carrington M,Chen ZG,Sidney J,Sette A,Saba NF,Wieland A,Ahmed R
Wed Sep 01 00:00:00 EDT 2021
A vaccine targeting mutant IDH1 in newly diagnosed glioma.
Nature
Platten M,Bunse L,Wick A,Bunse T,Le Cornet L,Harting I,Sahm F,Sanghvi K,Tan CL,Poschke I,Green E,Justesen S,Behrens GA,Breckwoldt MO,Freitag A,Rother LM,Schmitt A,Schnell O,Hense J,Misch M,Krex D,Stevanovic S,Tabatabai G,Steinbach JP,Bendszus M,von Deimling A,Schmitt M,Wick W
Thu Apr 01 00:00:00 EDT 2021
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.
Cell
Chen PJ,Hussmann JA,Yan J,Knipping F,Ravisankar P,Chen PF,Chen C,Nelson JW,Newby GA,Sahin M,Osborn MJ,Weissman JS,Adamson B,Liu DR
Thu Oct 28 00:00:00 EDT 2021
Vaccination reshapes the virus-specific T cell repertoire in unexposed adults.
Immunity
Pan YG,Aiamkitsumrit B,Bartolo L,Wang Y,Lavery C,Marc A,Holec PV,Rappazzo CG,Eilola T,Gimotty PA,Hensley SE,Antia R,Zarnitsyna VI,Birnbaum ME,Su LF
200-07 was used in In vitro experiments to examine how baseline CD4+ T cell repertoire and precursor states impact responses to pathogen infection in humans using primary immunization with yellow fever virus vaccine.
Tue Jun 08 00:00:00 EDT 2021
Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response.
Immunity
Golebski K,Layhadi JA,Sahiner U,Steveling-Klein EH,Lenormand MM,Li RCY,Bal SM,Heesters BA,Vilà-Nadal G,Hunewald O,Montamat G,He FQ,Ollert M,Fedina O,Lao-Araya M,Vijverberg SJH,Maitland-van der Zee AH,van Drunen CM,Fokkens WJ,Durham SR,Spits H,Shamji MH
Tue Feb 09 00:00:00 EST 2021
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.
Immunity
Ehx G,Larouche JD,Durette C,Laverdure JP,Hesnard L,Vincent K,Hardy MP,Thériault C,Rulleau C,Lanoix J,Bonneil E,Feghaly A,Apavaloaei A,Noronha N,Laumont CM,Delisle JS,Vago L,Hébert J,Sauvageau G,Lemieux S,Thibault P,Perreault C
Tue Apr 13 00:00:00 EDT 2021
Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR-T-cell responses against ALL.
Blood
Zheng W,Wei J,Zebley CC,Jones LL,Dhungana Y,Wang YD,Mavuluri J,Long L,Fan Y,Youngblood B,Chi H,Geiger TL
Thu Jul 15 00:00:00 EDT 2021
A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors.
Cellular & molecular immunology
Moirangthem RD,Ma K,Lizot S,Cordesse A,Olivré J,de Chappedelaine C,Joshi A,Cieslak A,Tchen J,Cagnard N,Asnafi V,Rausell A,Simons L,Zuber J,Taghon T,Staal FJT,Pflumio F,Six E,Cavazzana M,Lagresle-Peyrou C,Soheili T,André I
Thu Jul 01 00:00:00 EDT 2021
Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice.
The Journal of clinical investigation
Harro CM,Perez-Sanz J,Costich TL,Payne KK,Anadon CM,Chaurio RA,Biswas S,Mandal G,Rigolizzo KE,Sprenger KB,Mine JA,Showe LC,Yu X,Liu K,Rodriguez PC,Pinilla-Ibarz J,Sokol L,Conejo-Garcia JR
Mon Feb 01 00:00:00 EST 2021
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.
The Journal of experimental medicine
Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ
Mon Feb 01 00:00:00 EST 2021
STING agonist promotes CAR T cell trafficking and persistence in breast cancer.
The Journal of experimental medicine
Xu N,Palmer DC,Robeson AC,Shou P,Bommiasamy H,Laurie SJ,Willis C,Dotti G,Vincent BG,Restifo NP,Serody JS
Mon Feb 01 00:00:00 EST 2021
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
EMBO molecular medicine
Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P
Fri Mar 05 00:00:00 EST 2021
Fever supports CD8+ effector T cell responses by promoting mitochondrial translation.
Proceedings of the National Academy of Sciences of the United States of America
O'Sullivan D,Stanczak MA,Villa M,Uhl FM,Corrado M,Klein Geltink RI,Sanin DE,Apostolova P,Rana N,Edwards-Hicks J,Grzes KM,Kabat AM,Kyle RL,Fabri M,Curtis JD,Buck MD,Patterson AE,Regina A,Field CS,Baixauli F,Puleston DJ,Pearce EJ,Zeiser R,Pearce EL
Tue Jun 22 00:00:00 EDT 2021
Engineering of human induced pluripotent stem cells via human artificial chromosome vectors for cell therapy and disease modeling.
Molecular therapy. Nucleic acids
Kazuki Y,Uno N,Abe S,Kajitani N,Kazuki K,Yakura Y,Sawada C,Takata S,Sugawara M,Nagashima Y,Okada A,Hiratsuka M,Osaki M,Ferrari G,Tedesco FS,Nishikawa S,Fukumoto K,Takayanagi SI,Kunisato A,Kaneko S,Oshimura M,Tomizuka K
Fri Mar 05 00:00:00 EST 2021
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity.
Mucosal immunology
Qiu J,Zhang J,Ji Y,Sun H,Gu Z,Sun Q,Bai M,Gong J,Tang J,Zhang Y,Li S,Shao Z,Li J,Sheng H,Shen L,Qiu J
Mon Nov 01 00:00:00 EDT 2021
Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.
International journal of cancer
Herda S,Heimann A,Obermayer B,Ciraolo E,Althoff S,Ruß J,Grunert C,Busse A,Bullinger L,Pezzutto A,Blankenstein T,Beule D,Na IK
Tue Jun 15 00:00:00 EDT 2021
Development of T-cell immunity in a liver and hematopoietic stem cell transplant recipient following coronavirus disease 2019 infection.
Cytotherapy
Soni M,Migliori E,Assal A,Chan HT,Ciubotariu R,Pan JB,Cicero K,Pereira M,Mapara MY,Muranski P
Mon Nov 01 00:00:00 EDT 2021
CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.
Stem cells (Dayton, Ohio)
Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM
Sat May 01 00:00:00 EDT 2021
CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.
Stem cells (Dayton, Ohio)
Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM
Sat May 01 00:00:00 EDT 2021
Methylation-Sensitive Restriction Enzyme Quantitative Polymerase Chain Reaction Enables Rapid, Accurate, and Precise Detection of Methylation Status of the Regulatory T Cell (Treg)-Specific Demethylation Region in Primary Human Tregs.
Journal of immunology (Baltimore, Md. : 1950)
Perry N,Wasko K,Cheng J,Tabbaa D,Marco E,Giannoukos G,Albright CF,Borges CM
Fri Jan 15 00:00:00 EST 2021
GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma - assessing tumor and T cell interaction.
Translational oncology
Sujjitjoon J,Sayour E,Tsao ST,Uiprasertkul M,Sanpakit K,Buaboonnam J,Yenchitsomanus PT,Atchaneeyasakul LO,Chang LJ
Mon Feb 01 00:00:00 EST 2021
Peripheral leukemia burden at time of apheresis negatively affects the clinical efficacy of CART19 in refractory or relapsed B-ALL.
Molecular therapy. Methods & clinical development
Deng B,Pan J,Liu Z,Liu S,Chen Y,Qu X,Zhang Y,Lin Y,Zhang Y,Yu X,Zhang Z,Niu X,Luan R,Ma M,Li X,Liu T,Wu X,Niu H,Chang AH,Tong C
Fri Dec 10 00:00:00 EST 2021
Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors.
iScience
Portillo AL,Hogg R,Poznanski SM,Rojas EA,Cashell NJ,Hammill JA,Chew MV,Shenouda MM,Ritchie TM,Cao QT,Hirota JA,Dhesy-Thind S,Bramson JL,Ashkar AA
Fri Jun 25 00:00:00 EDT 2021
IL-15 enhances CCR5-mediated migration of memory CD8+ T cells by upregulating CCR5 expression in the absence of TCR stimulation.
Cell reports
Seo IH,Eun HS,Kim JK,Lee H,Jeong S,Choi SJ,Lee J,Lee BS,Kim SH,Rou WS,Lee DH,Kim W,Park SH,Shin EC
Tue Jul 27 00:00:00 EDT 2021
Multi-scale Dynamical Modeling of T Cell Development from an Early Thymic Progenitor State to Lineage Commitment.
Cell reports
Olariu V,Yui MA,Krupinski P,Zhou W,Deichmann J,Andersson E,Rothenberg EV,Peterson C
Tue Jan 12 00:00:00 EST 2021
Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics.
Nature communications
Wilhelm M,Zolg DP,Graber M,Gessulat S,Schmidt T,Schnatbaum K,Schwencke-Westphal C,Seifert P,de Andrade Krätzig N,Zerweck J,Knaute T,Bräunlein E,Samaras P,Lautenbacher L,Klaeger S,Wenschuh H,Rad R,Delanghe B,Huhmer A,Carr SA,Clauser KR,Krackhardt AM,Reimer U,Kuster B
Mon Jun 07 00:00:00 EDT 2021
Characteristics of Immune Memory and Effector Activity to Cancer-Expressed MHC Class I Phosphopeptides Differ in Healthy Donors and Ovarian Cancer Patients.
Cancer immunology research
Lulu AM,Cummings KL,Jeffery ED,Myers PT,Underwood D,Lacy RM,Chianese-Bullock KA,Slingluff CL,Modesitt SC,Engelhard VH
200-07 was used in In vitro experiments to suggest that the immunogens generating most phosphopeptide-specific immune memory are rare infectious agents or incipient cancer cells with distinct phosphoproteome dysregulations, and that repetitive immunogenic exposures occur in individual donors.
Mon Nov 01 00:00:00 EDT 2021
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.
Nature communications
Fischer DS,Ansari M,Wagner KI,Jarosch S,Huang Y,Mayr CH,Strunz M,Lang NJ,D'Ippolito E,Hammel M,Mateyka L,Weber S,Wolff LS,Witter K,Fernandez IE,Leuschner G,Milger K,Frankenberger M,Nowak L,Heinig-Menhard K,Koch I,Stoleriu MG,Hilgendorff A,Behr J,Pichlmair A,Schubert B,Theis FJ,Busch DH,Schiller HB,Schober K
Mon Jul 26 00:00:00 EDT 2021
Identification of HLA-A2-Restricted Mutant Epitopes from Neoantigens of Esophageal Squamous Cell Carcinoma.
Vaccines
Wang Z,Ran L,Chen C,Shi R,Dong Y,Li Y,Zhou X,Qi Y,Zhu P,Gao Y,Wu Y
200-07 was used in In vitro experiments to investigate treatment for esophageal squamous cell carcinoma.
Fri Oct 01 00:00:00 EDT 2021
Directly reprogrammed natural killer cells for cancer immunotherapy.
Nature biomedical engineering
Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS
Mon Nov 01 00:00:00 EDT 2021
The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.
Communications biology
Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S
Mon Jun 07 00:00:00 EDT 2021
Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemics.
Scientific reports
Sivapalan R,Liu J,Chakraborty K,Arthofer E,Choudhry M,Barie PS,Barouch DH,Henley T
Tue Jul 27 00:00:00 EDT 2021
Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques.
Molecular therapy. Methods & clinical development
Haeseleer F,Fukazawa Y,Park H,Varco-Merth B,Rust BJ,Smedley JV,Eichholz K,Peterson CW,Mason R,Kiem HP,Roederer M,Picker LJ,Okoye AA,Corey L
Fri Sep 10 00:00:00 EDT 2021
Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples.
Molecular & cellular proteomics : MCP
Klaeger S,Apffel A,Clauser KR,Sarkizova S,Oliveira G,Rachimi S,Le PM,Tarren A,Chea V,Abelin JG,Braun DA,Ott PA,Keshishian H,Hacohen N,Keskin DB,Wu CJ,Carr SA
Thu Mar 24 00:00:00 EDT 2022
Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.
Cell reports
Zebley CC,Abdelsamed HA,Ghoneim HE,Alli S,Brown C,Haydar D,Mi T,Harris T,McGargill MA,Krenciute G,Youngblood B
Tue Oct 12 00:00:00 EDT 2021
SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.
Cell reports
Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II
200-07 was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.
Tue Feb 16 00:00:00 EST 2021
Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer.
STAR protocols
Rotolo A,Atherton MJ,Kasper BT,Haran KP,Mason NJ
200-07 was used in In vitro experiments to optimize a retrovirus-based protocol to efficiently CAR transduce primary T cells from healthy and tumor-bearing dogs.
Fri Dec 17 00:00:00 EST 2021
Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.
Cell reports. Medicine
Müller TR,Jarosch S,Hammel M,Leube J,Grassmann S,Bernard B,Effenberger M,Andrä I,Chaudhry MZ,Käuferle T,Malo A,Cicin-Sain L,Steinberger P,Feuchtinger T,Protzer U,Schumann K,Neuenhahn M,Schober K,Busch DH
Tue Aug 17 00:00:00 EDT 2021
Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients.
Cell reports
Reid JC,Golubeva D,Boyd AL,Hollands CG,Henly C,Orlando L,Leber A,Hébert J,Morabito F,Cutrona G,Agnelli L,Gentile M,Ferrarini M,Neri A,Leber B,Bhatia M
Tue Mar 16 00:00:00 EDT 2021
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint.
Nature communications
Schmidt NM,Wing PAC,Diniz MO,Pallett LJ,Swadling L,Harris JM,Burton AR,Jeffery-Smith A,Zakeri N,Amin OE,Kucykowicz S,Heemskerk MH,Davidson B,Meyer T,Grove J,Stauss HJ,Pineda-Torra I,Jolly C,Jury EC,McKeating JA,Maini MK
Fri May 14 00:00:00 EDT 2021
JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells.
Communications biology
Lee HK,Jung O,Hennighausen L
Wed Jun 02 00:00:00 EDT 2021
Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.
Cell reports. Medicine
Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L
200-07 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.
Tue Nov 16 00:00:00 EST 2021
EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8+ T Cells.
Frontiers in immunology
Stairiker CJ,Pfister SX,Hendrickson E,Yang W,Xie T,Lee C,Zhang H,Dillon C,Thomas GD,Salek-Ardakani S
200-07 was used in In vitro experiments to support the requirement of EZH2 function in 4-1BB-mediated CD8+ T cell expansion and effector programming and emphasize the consideration that must be given when combining such antitumoral therapies.
Mon Feb 14 00:00:00 EST 2022
Next Generation Sequencing-Based Identification of T-Cell Receptors for Immunotherapy Against Hepatocellular Carcinoma.
Hepatology communications
Ma Y,Ou J,Lin T,Chen L,Chen J,Wang M
Tue Jun 01 00:00:00 EDT 2021
PD-1 Affects the Immunosuppressive Function of Group 2 Innate Lymphoid Cells in Human Non-Small Cell Lung Cancer.
Frontiers in immunology
Shen C,Liu C,Zhang Z,Ping Y,Shao J,Tian Y,Yu W,Qin G,Liu S,Wang L,Zhang Y
200-07 was used in Sample Preparation (FC/FACS) to show that ILC2s are enriched in NSCLC patients and upregulate PD-1 expression.
Mon Oct 25 00:00:00 EDT 2021
Dual Targeting CAR-T Cells with Optimal Costimulation and Metabolic Fitness enhance Antitumor Activity and Prevent Escape in Solid Tumors.
Nature cancer
Hirabayashi K,Du H,Xu Y,Shou P,Zhou X,Fucá G,Landoni E,Sun C,Chen Y,Savoldo B,Dotti G
Wed Sep 01 00:00:00 EDT 2021
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program.
Nature communications
Rice S,Jackson T,Crump NT,Fordham N,Elliott N,O'Byrne S,Fanego MDML,Addy D,Crabb T,Dryden C,Inglott S,Ladon D,Wright G,Bartram J,Ancliff P,Mead AJ,Halsey C,Roberts I,Milne TA,Roy A
Thu Nov 25 00:00:00 EST 2021
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
Cell
Ruscetti M,Morris JP,Mezzadra R,Russell J,Leibold J,Romesser PB,Simon J,Kulick A,Ho YJ,Fennell M,Li J,Norgard RJ,Wilkinson JE,Alonso-Curbelo D,Sridharan R,Heller DA,de Stanchina E,Stanger BZ,Sherr CJ,Lowe SW
200-07 was used in Cell Culture to show that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling can suppress PDAC proliferation through induction of retinoblastoma (RB) protein-mediated senescence.
Thu Apr 16 00:00:00 EDT 2020
Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development.
Immunity
Le J,Park JE,Ha VL,Luong A,Branciamore S,Rodin AS,Gogoshin G,Li F,Loh YE,Camacho V,Patel SB,Welner RS,Parekh C
Tue Jun 16 00:00:00 EDT 2020
THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells.
Cancer cell
Sun C,Shou P,Du H,Hirabayashi K,Chen Y,Herring LE,Ahn S,Xu Y,Suzuki K,Li G,Tsahouridis O,Su L,Savoldo B,Dotti G
Mon Feb 10 00:00:00 EST 2020
Genome-wide transcriptome analysis of the STAT6-regulated genes in advanced-stage cutaneous T-cell lymphoma.
Blood
Gaydosik AM,Queen DS,Trager MH,Akilov OE,Geskin LJ,Fuschiotti P
Thu Oct 08 00:00:00 EDT 2020
Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates.
Blood
Rust BJ,Kean LS,Colonna L,Brandenstein KE,Poole NH,Obenza W,Enstrom MR,Maldini CR,Ellis GI,Fennessey CM,Huang ML,Keele BF,Jerome KR,Riley JL,Kiem HP,Peterson CW
Thu Oct 08 00:00:00 EDT 2020
Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma.
Blood
De Smedt R,Morscio J,Reunes L,Roels J,Bardelli V,Lintermans B,Van Loocke W,Almeida A,Cheung LC,Kotecha RS,Mansour MR,Uyttebroeck A,Vandenberghe P,La Starza R,Mecucci C,Lammens T,Van Roy N,De Moerloose B,Barata JT,Taghon T,Goossens S,Van Vlierberghe P
Thu May 07 00:00:00 EDT 2020
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.
Blood
Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE
Thu Aug 06 00:00:00 EDT 2020
Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes.
The Journal of clinical investigation
Meyer LK,Huang BJ,Delgado-Martin C,Roy RP,Hechmer A,Wandler AM,Vincent TL,Fortina P,Olshen AB,Wood BL,Horton TM,Shannon KM,Teachey DT,Hermiston ML
Mon Feb 03 00:00:00 EST 2020
Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
The Journal of clinical investigation
Cao W,Fang F,Gould T,Li X,Kim C,Gustafson C,Lambert S,Weyand CM,Goronzy JJ
Wed Jul 01 00:00:00 EDT 2020
Mechanosensing through YAP controls T cell activation and metabolism.
The Journal of experimental medicine
Meng KP,Majedi FS,Thauland TJ,Butte MJ
200-07 was used in Sample Preparation (FC/FACS) to study how the YAP mechanosensor is required for sensing the microenvironment mechanical changes which cause lymph nodes to become mechanically stiff as immune cells activate and proliferate within their encapsulated environments.
Mon Aug 03 00:00:00 EDT 2020
CARD8 inflammasome activation triggers pyroptosis in human T cells.
The EMBO journal
Linder A,Bauernfried S,Cheng Y,Albanese M,Jung C,Keppler OT,Hornung V
Thu Oct 01 00:00:00 EDT 2020
Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.
Proceedings of the National Academy of Sciences of the United States of America
Wang T,Medynets M,Johnson KR,Doucet-O'Hare TT,DiSanza B,Li W,Xu Y,Bagnell A,Tyagi R,Sampson K,Malik N,Steiner J,Hadegan A,Kowalak J,O'Malley J,Maric D,Nath A
Tue Jul 28 00:00:00 EDT 2020
IL-7 induces sCD127 release and mCD127 downregulation in human CD8+ T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection.
European journal of immunology
Côté SC,Burke Schinkel SC,Berthoud TK,Barros PO,Sanchez-Vidales M,Davidson AM,Crawley AM,Angel JB
Thu Oct 01 00:00:00 EDT 2020
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response.
Oncogenesis
Giuli MV,Diluvio G,Giuliani E,Franciosa G,Di Magno L,Pignataro MG,Tottone L,Nicoletti C,Besharat ZM,Peruzzi G,Pelullo M,Palermo R,Canettieri G,Talora C,d'Amati G,Bellavia D,Screpanti I,Checquolo S
Sun Oct 18 00:00:00 EDT 2020
Physioxia enhances T-cell development ex vivo from human hematopoietic stem and progenitor cells.
Stem cells (Dayton, Ohio)
Shin DY,Huang X,Gil CH,Aljoufi A,Ropa J,Broxmeyer HE
Sun Nov 01 00:00:00 EDT 2020
p53 Hinders CRISPR/Cas9-Mediated Targeted Gene Disruption in Memory CD8 T Cells In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Kurup SP,Moioffer SJ,Pewe LL,Harty JT
Thu Oct 15 00:00:00 EDT 2020
Expansion of Group 2 Innate Lymphoid Cells in Patients with End-Stage Renal Disease and Their Clinical Significance.
Journal of immunology (Baltimore, Md. : 1950)
Liu GY,Deng XH,Li X,Cao YJ,Xing YF,Zhou P,Lei AH,Yang Q,Deng K,Zhang H,Zhou J
Wed Jul 01 00:00:00 EDT 2020
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.
Nature communications
Kared H,Tan SW,Lau MC,Chevrier M,Tan C,How W,Wong G,Strickland M,Malleret B,Amoah A,Pilipow K,Zanon V,Govern NM,Lum J,Chen JM,Lee B,Florian MC,Geiger H,Ginhoux F,Ruiz-Mateos E,Fulop T,Rajasuriar R,Kamarulzaman A,Ng TP,Lugli E,Larbi A
Mon Feb 10 00:00:00 EST 2020
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.
Nature communications
Kared H,Tan SW,Lau MC,Chevrier M,Tan C,How W,Wong G,Strickland M,Malleret B,Amoah A,Pilipow K,Zanon V,Govern NM,Lum J,Chen JM,Lee B,Florian MC,Geiger H,Ginhoux F,Ruiz-Mateos E,Fulop T,Rajasuriar R,Kamarulzaman A,Ng TP,Lugli E,Larbi A
Mon Feb 10 00:00:00 EST 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
200-07 was used in In vitro experiments to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 EST 2020
B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models.
Oncoimmunology
Huang B,Luo L,Wang J,He B,Feng R,Xian N,Zhang Q,Chen L,Huang G
200-07 was used in In vitro experiments to indicate that B7-H3 specific CAR-T cells have the potential to treat multiple types of advanced solid tumors.
Wed Jul 28 00:00:00 EDT 2021
iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests.
Stem cell reports
Themeli M,Chhatta A,Boersma H,Prins HJ,Cordes M,de Wilt E,Farahani AS,Vandekerckhove B,van der Burg M,Hoeben RC,Staal FJT,Mikkers HMM
Tue Feb 11 00:00:00 EST 2020
GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision.
Nature cancer
Wang K,Chen Y,Ahn S,Zheng M,Landoni E,Dotti G,Savoldo B,Han Z
Thu Oct 01 00:00:00 EDT 2020
Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation.
Nature communications
Li ZL,Zhang HL,Huang Y,Huang JH,Sun P,Zhou NN,Chen YH,Mai J,Wang Y,Yu Y,Zhou LH,Li X,Yang D,Peng XD,Feng GK,Tang J,Zhu XF,Deng R
200-07 was used in In vitro experiments to provide a potential strategy for targeting triple-negative breast cancer with the combination of Tenascin-C blockade and immune checkpoint inhibitors.
Thu Jul 30 00:00:00 EDT 2020
CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation.
Scientific reports
Elmetwali T,Salman A,Wei W,Hussain SA,Young LS,Palmer DH
Wed Jan 15 00:00:00 EST 2020
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion.
Nature communications
Nahmad AD,Raviv Y,Horovitz-Fried M,Sofer I,Akriv T,Nataf D,Dotan I,Carmi Y,Burstein D,Wine Y,Benhar I,Barzel A
Tue Nov 17 00:00:00 EST 2020
Streamlined selection of cancer antigens for vaccine development through integrative multi-omics and high-content cell imaging.
Scientific reports
Han KC,Park D,Ju S,Lee YE,Heo SH,Kim YA,Lee JE,Lee Y,Park KH,Park SH,Lee HJ,Lee C,Jang M
Fri Apr 03 00:00:00 EDT 2020
Toll-like receptor 7/8-matured RNA-transduced dendritic cells as post-remission therapy in acute myeloid leukaemia: results of a phase I trial.
Clinical & translational immunology
Lichtenegger FS,Schnorfeil FM,Rothe M,Deiser K,Altmann T,Bücklein VL,Köhnke T,Augsberger C,Konstandin NP,Spiekermann K,Moosmann A,Boehm S,Boxberg M,Heemskerk MH,Goerlich D,Wittmann G,Wagner B,Hiddemann W,Schendel DJ,Kvalheim G,Bigalke I,Subklewe M
Wed Apr 13 00:00:00 EDT 2022
Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.
Immunity
Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H
Tue Nov 19 00:00:00 EST 2019
Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells.
Cancer cell
Du H,Hirabayashi K,Ahn S,Kren NP,Montgomery SA,Wang X,Tiruthani K,Mirlekar B,Michaud D,Greene K,Herrera SG,Xu Y,Sun C,Chen Y,Ma X,Ferrone CR,Pylayeva-Gupta Y,Yeh JJ,Liu R,Savoldo B,Ferrone S,Dotti G
Mon Feb 11 00:00:00 EST 2019
γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia.
Cancer cell
Luong-Gardiol N,Siddiqui I,Pizzitola I,Jeevan-Raj B,Charmoy M,Huang Y,Irmisch A,Curtet S,Angelov GS,Danilo M,Juilland M,Bornhauser B,Thome M,Hantschel O,Chalandon Y,Cazzaniga G,Bourquin JP,Huelsken J,Held W
Mon Apr 15 00:00:00 EDT 2019
Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.
Nature immunology
Cella M,Gamini R,Sécca C,Collins PL,Zhao S,Peng V,Robinette ML,Schettini J,Zaitsev K,Gordon W,Bando JK,Yomogida K,Cortez V,Fronick C,Fulton R,Lin LL,Gilfillan S,Flavell RA,Shan L,Artyomov MN,Bowman M,Oltz EM,Jelinsky SA,Colonna M
200-07 was used in In vitro experiments to demonstrate that innate lymphoid cells (ILCs) undergo conversion from ILC3s into ILC1-like cells in human tissues in vivo, requiring tissue factors and Aiolos in the process.
Thu Aug 01 00:00:00 EDT 2019
Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.
Blood
Weijenborg Campos L,Pini Zenatti P,Granato Pissinato L,Libanio Rodrigues GO,Artico LL,Rafael Guimarães T,Fröhlich Archangelo L,Martínez L,Brooks AJ,Yunes JA
Thu Mar 14 00:00:00 EDT 2019
Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.
Blood
Weijenborg Campos L,Pini Zenatti P,Granato Pissinato L,Libanio Rodrigues GO,Artico LL,Rafael Guimarães T,Fröhlich Archangelo L,Martínez L,Brooks AJ,Yunes JA
Thu Mar 14 00:00:00 EDT 2019
Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.
Cell stem cell
Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L
200-07 was used in Sample Preparation (FC/FACS) to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.
Thu Oct 03 00:00:00 EDT 2019
A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation.
The Journal of experimental medicine
Fernandez IZ,Baxter RM,Garcia-Perez JE,Vendrame E,Ranganath T,Kong DS,Lundquist K,Nguyen T,Ogolla S,Black J,Galambos C,Gumbart JC,Dawany N,Kelsen JR,de Zoeten EF,Quinones R,Eissa H,Verneris MR,Sullivan KE,Rochford R,Blish CA,Kedl RM,Dutmer CM,Hsieh EWY
200-07 was used in In vitro experiments to investigate the clinical and immunological phenotypes of two siblings with the first described human IL-2Rβ defect.
Mon Jun 03 00:00:00 EDT 2019
Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.
The Journal of experimental medicine
Zhang Z,Gothe F,Pennamen P,James JR,McDonald D,Mata CP,Modis Y,Alazami AM,Acres M,Haller W,Bowen C,Döffinger R,Sinclair J,Brothers S,Zhang Y,Matthews HF,Naudion S,Pelluard F,Alajlan H,Yamazaki Y,Notarangelo LD,Thaventhiran JE,Engelhardt KR,Al-Mousa H,Hambleton S,Rooryck C,Smith KGC,Lenardo MJ
Mon Jun 03 00:00:00 EDT 2019
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.
Leukemia
Akkapeddi P,Fragoso R,Hixon JA,Ramalho AS,Oliveira ML,Carvalho T,Gloger A,Matasci M,Corzana F,Durum SK,Neri D,Bernardes GJL,Barata JT
Sun Sep 01 00:00:00 EDT 2019
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.
Leukemia
Akkapeddi P,Fragoso R,Hixon JA,Ramalho AS,Oliveira ML,Carvalho T,Gloger A,Matasci M,Corzana F,Durum SK,Neri D,Bernardes GJL,Barata JT
Sun Sep 01 00:00:00 EDT 2019
NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia.
Leukemia
Lopez-Millan B,Sanchéz-Martínez D,Roca-Ho H,Gutiérrez-Agüera F,Molina O,Diaz de la Guardia R,Torres-Ruiz R,Fuster JL,Ballerini P,Suessbier U,Nombela-Arrieta C,Bueno C,Menéndez P
Mon Jul 01 00:00:00 EDT 2019
Breaking tolerance with engineered class I antigen-presenting molecules.
Proceedings of the National Academy of Sciences of the United States of America
Parks CA,Henning KR,Pavelko KD,Hansen MJ,Van Keulen VP,Reed BK,Stone JD,Schrum AG,Gil D,Kranz DM,Bordner AJ,Barry MA,Pease LR
Tue Feb 19 00:00:00 EST 2019
MicroRNA-155 Expression Is Enhanced by T-cell Receptor Stimulation Strength and Correlates with Improved Tumor Control in Melanoma.
Cancer immunology research
Martinez-Usatorre A,Sempere LF,Carmona SJ,Carretero-Iglesia L,Monnot G,Speiser DE,Rufer N,Donda A,Zehn D,Jandus C,Romero P
200-07 was used in Cell Culture to explore the regulation of miR-155 expression in CD8+ cells.
Sat Jun 01 00:00:00 EDT 2019
Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.
Cell systems
Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV
200-07 was used in Cell Culture to imply that multilineage priming is integral to T cell specification.
Wed Oct 23 00:00:00 EDT 2019
Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Anderson W,Thorpe J,Long SA,Rawlings DJ
Sun Dec 15 00:00:00 EST 2019
Gene correction for SCID-X1 in long-term hematopoietic stem cells.
Nature communications
Pavel-Dinu M,Wiebking V,Dejene BT,Srifa W,Mantri S,Nicolas CE,Lee C,Bao G,Kildebeck EJ,Punjya N,Sindhu C,Inlay MA,Saxena N,DeRavin SS,Malech H,Roncarolo MG,Weinberg KI,Porteus MH
Tue Apr 09 00:00:00 EDT 2019
Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma.
Cells
Yazdanifar M,Zhou R,Grover P,Williams C,Bose M,Moore LJ,Wu ST,Maher J,Dreau D,Mukherjee AP
200-07 was used in In vitro experiments to show that combination of CAR T cells and biological inhibitors of IDO1, COX1/2, and Gal-9 resulted in significant enhancement of CAR T cell cytotoxicity against PDA cells.
Wed Sep 11 00:00:00 EDT 2019
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.
Nature communications
Fan J,Liang H,Ji X,Wang S,Xue J,Li D,Peng H,Qin C,Yee C,Shao Y
Tue May 21 00:00:00 EDT 2019
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.
Nature communications
Fan J,Liang H,Ji X,Wang S,Xue J,Li D,Peng H,Qin C,Yee C,Shao Y
Tue May 21 00:00:00 EDT 2019
Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele.
Nature communications
Al-Mossawi H,Yager N,Taylor CA,Lau E,Danielli S,de Wit J,Gilchrist J,Nassiri I,Mahe EA,Lee W,Rizvi L,Makino S,Cheeseman J,Neville M,Knight JC,Bowness P,Fairfax BP
Tue Oct 08 00:00:00 EDT 2019
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.
Nature communications
Nayak RC,Hegde S,Althoff MJ,Wellendorf AM,Mohmoud F,Perentesis J,Reina-Campos M,Reynaud D,Zheng Y,Diaz-Meco MT,Moscat J,Cancelas JA
Fri Jan 04 00:00:00 EST 2019
Interleukin-7 Contributes to the Invasiveness of Prostate Cancer Cells by Promoting Epithelial-Mesenchymal Transition.
Scientific reports
Seol MA,Kim JH,Oh K,Kim G,Seo MW,Shin YK,Sim JH,Shin HM,Seo BY,Lee DS,Ku JL,Han I,Kang I,Park SI,Kim HR
Mon May 06 00:00:00 EDT 2019
Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides.
Cell death & disease
Zhang G,Luk BT,Wei X,Campbell GR,Fang RH,Zhang L,Spector SA
Wed May 29 00:00:00 EDT 2019
Low immunogenic endothelial cells endothelialize the Left Ventricular Assist Device.
Scientific reports
Figueiredo C,Eicke D,Yuzefovych Y,Avsar M,Hanke JS,Pflaum M,Schmitto JD,Blasczyk R,Haverich A,Wiegmann B
Mon Aug 05 00:00:00 EDT 2019
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.
Nature communications
Kusakabe M,Sun AC,Tyshchenko K,Wong R,Nanda A,Shanna C,Gusscott S,Chavez EA,Lorzadeh A,Zhu A,Hill A,Hung S,Brown S,Babaian A,Wang X,Holt RA,Steidl C,Karsan A,Humphries RK,Eaves CJ,Hirst M,Weng AP
Tue Jul 02 00:00:00 EDT 2019
Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.
Current protocols in immunology
Souter MNT,Loh L,Li S,Meehan BS,Gherardin NA,Godfrey DI,Rossjohn J,Fairlie DP,Kedzierska K,Pellicci DG,Chen Z,Kjer-Nielsen L,Corbett AJ,McCluskey J,Eckle SBG
200-07 was used in Cell Culture to describe protocols to characterize the phenotype of human MAIT cells in blood and tissues by flow cytometry using fluorescently labeled human MR1 tetramers alongside antibodies specific for MAIT cell markers.
Sun Dec 01 00:00:00 EST 2019
UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.
Scientific reports
Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II
Mon Apr 29 00:00:00 EDT 2019
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Nature
Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C
Sat Dec 01 00:00:00 EST 2018
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Nature
Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C
Sat Dec 01 00:00:00 EST 2018
Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A.
Immunity
Kim J,Chang DY,Lee HW,Lee H,Kim JH,Sung PS,Kim KH,Hong SH,Kang W,Lee J,Shin SY,Yu HT,You S,Choi YS,Oh I,Lee DH,Lee DH,Jung MK,Suh KS,Hwang S,Kim W,Park SH,Kim HJ,Shin EC
Tue Jan 16 00:00:00 EST 2018
The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells.
Immunity
Bando JK,Gilfillan S,Song C,McDonald KG,Huang SC,Newberry RD,Kobayashi Y,Allan DSJ,Carlyle JR,Cella M,Colonna M
Tue Jun 19 00:00:00 EDT 2018
Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.
Immunity
Hosokawa H,Ungerbäck J,Wang X,Matsumoto M,Nakayama KI,Cohen SM,Tanaka T,Rothenberg EV
Tue Jun 19 00:00:00 EDT 2018
Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.
Cancer cell
Booth CAG,Barkas N,Neo WH,Boukarabila H,Soilleux EJ,Giotopoulos G,Farnoud N,Giustacchini A,Ashley N,Carrelha J,Jamieson L,Atkinson D,Bouriez-Jones T,Prinjha RK,Milne TA,Teachey DT,Papaemmanuil E,Huntly BJP,Jacobsen SEW,Mead AJ
Mon Feb 12 00:00:00 EST 2018
SMAC Mimetics Induce Autophagy-Dependent Apoptosis of HIV-1-Infected Resting Memory CD4+ T Cells.
Cell host & microbe
Campbell GR,Bruckman RS,Chu YL,Trout RN,Spector SA
200-07 was used in Cell Culture to study how DIABLO/SMAC mimetics (birinapant, GDC-0152, and embelin) selectively kill HIV-Long-lived resting memory CD4+ T cells (TCM) without increasing virus production or targeting uninfected TCM.
Wed Nov 14 00:00:00 EST 2018
Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.
The Journal of experimental medicine
Li N,van Unen V,Höllt T,Thompson A,van Bergen J,Pezzotti N,Eisemann E,Vilanova A,Chuva de Sousa Lopes SM,Lelieveldt BPF,Koning F
Mon May 07 00:00:00 EDT 2018
Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.
The Journal of experimental medicine
Li N,van Unen V,Höllt T,Thompson A,van Bergen J,Pezzotti N,Eisemann E,Vilanova A,Chuva de Sousa Lopes SM,Lelieveldt BPF,Koning F
Mon May 07 00:00:00 EDT 2018
A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.
Developmental cell
Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T
200-07 was used in In vitro experiments to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.
Mon Feb 05 00:00:00 EST 2018
Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.
Frontiers in immunology
Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M
200-07 was used in Sample Preparation (FC/FACS) to compare the efficacy of dendritic cell receptor-ligand blockades at various immune checkpoints on T cell activation, an suggest targets for enhanced immunotherapy.
Mon Apr 08 00:00:00 EDT 2019
Activation of Th1 Immunity within the Tumor Microenvironment Is Associated with Clinical Response to Lenalidomide in Chronic Lymphocytic Leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Aue G,Sun C,Liu D,Park JH,Pittaluga S,Tian X,Lee E,Soto S,Valdez J,Maric I,Stetler-Stevenson M,Yuan C,Nakamura Y,Muranski P,Wiestner A
Mon Oct 01 00:00:00 EDT 2018
IL-21 Selectively Protects CD62L+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Ngai H,Tian G,Courtney AN,Ravari SB,Guo L,Liu B,Jin J,Shen ET,Di Pierro EJ,Metelitsa LS
Mon Oct 01 00:00:00 EDT 2018
Directed evolution of CRISPR-Cas9 to increase its specificity.
Nature communications
Lee JK,Jeong E,Lee J,Jung M,Shin E,Kim YH,Lee K,Jung I,Kim D,Kim S,Kim JS
Mon Aug 06 00:00:00 EDT 2018
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity.
Nature communications
Helsen CW,Hammill JA,Lau VWC,Mwawasi KA,Afsahi A,Bezverbnaya K,Newhook L,Hayes DL,Aarts C,Bojovic B,Denisova GF,Kwiecien JM,Brain I,Derocher H,Milne K,Nelson BH,Bramson JL
Fri Aug 03 00:00:00 EDT 2018
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Nature communications
Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II
Tue May 08 00:00:00 EDT 2018
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells.
Nature communications
Mudd JC,Busman-Sahay K,DiNapoli SR,Lai S,Sheik V,Lisco A,Deleage C,Richardson B,Palesch DJ,Paiardini M,Cameron M,Sereti I,Reeves RK,Estes JD,Brenchley JM
Thu Sep 27 00:00:00 EDT 2018
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells.
Nature communications
Mudd JC,Busman-Sahay K,DiNapoli SR,Lai S,Sheik V,Lisco A,Deleage C,Richardson B,Palesch DJ,Paiardini M,Cameron M,Sereti I,Reeves RK,Estes JD,Brenchley JM
Thu Sep 27 00:00:00 EDT 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
200-07 was used in Cell Culture to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 EDT 2018
Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.
Cell reports
Balan S,Arnold-Schrauf C,Abbas A,Couespel N,Savoret J,Imperatore F,Villani AC,Vu Manh TP,Bhardwaj N,Dalod M
200-07 was used in Cell Culture to develop a dendritic cell (DC) differentiation method from human CD34+ precursors leading to high yields of plasmacytoid DCs and both types of conventional DCs.
Tue Aug 14 00:00:00 EDT 2018
Telomerase gene expression bioassays indicate metabolic activation of genotoxic lower chlorinated polychlorinated biphenyls.
Scientific reports
Vasko T,Hoffmann J,Gostek S,Schettgen T,Quinete N,Preisinger C,Kraus T,Ziegler P
Thu Nov 15 00:00:00 EST 2018
Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.
Nature communications
Laustsen A,Bak RO,Krapp C,Kjær L,Egedahl JH,Petersen CC,Pillai S,Tang HQ,Uldbjerg N,Porteus M,Roan NR,Nyegaard M,Denton PW,Jakobsen MR
Thu Aug 30 00:00:00 EDT 2018
Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.
Scientific reports
MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH
Tue May 22 00:00:00 EDT 2018
Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.
Scientific reports
MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH
Tue May 22 00:00:00 EDT 2018
CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir.
Nature communications
Badia R,Ballana E,Castellví M,García-Vidal E,Pujantell M,Clotet B,Prado JG,Puig J,Martínez MA,Riveira-Muñoz E,Esté JA
Mon Jul 16 00:00:00 EDT 2018
CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir.
Nature communications
Badia R,Ballana E,Castellví M,García-Vidal E,Pujantell M,Clotet B,Prado JG,Puig J,Martínez MA,Riveira-Muñoz E,Esté JA
Mon Jul 16 00:00:00 EDT 2018
Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response.
Stem cell reports
Ueda N,Uemura Y,Zhang R,Kitayama S,Iriguchi S,Kawai Y,Yasui Y,Tatsumi M,Ueda T,Liu TY,Mizoro Y,Okada C,Watanabe A,Nakanishi M,Senju S,Nishimura Y,Kuzushima K,Kiyoi H,Naoe T,Kaneko S
Tue Jun 05 00:00:00 EDT 2018
Personalized identification of tumor-associated immunogenic neoepitopes in hepatocellular carcinoma in complete remission after sorafenib treatment.
Oncotarget
Vrecko S,Guenat D,Mercier-Letondal P,Faucheu H,Dosset M,Royer B,Galaine J,Boidot R,Kim S,Jary M,Adotévi O,Borg C,Godet Y
200-07 was used in In vitro experiments to report and investigate the case of a patient diagnosed with an advanced hepatocellular carcinoma treated by sorafenib who experienced a complete histological response.
Tue Oct 23 00:00:00 EDT 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 EDT 2018
Origin and differentiation of human memory CD8 T cells after vaccination.
Nature
Akondy RS,Fitch M,Edupuganti S,Yang S,Kissick HT,Li KW,Youngblood BA,Abdelsamed HA,McGuire DJ,Cohen KW,Alexe G,Nagar S,McCausland MM,Gupta S,Tata P,Haining WN,McElrath MJ,Zhang D,Hu B,Greenleaf WJ,Goronzy JJ,Mulligan MJ,Hellerstein M,Ahmed R
Thu Dec 21 00:00:00 EST 2017
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
Mon Nov 13 00:00:00 EST 2017
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
Mon Nov 13 00:00:00 EST 2017
Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia.
Blood
Serafin V,Capuzzo G,Milani G,Minuzzo SA,Pinazza M,Bortolozzi R,Bresolin S,Porcù E,Frasson C,Indraccolo S,Basso G,Accordi B
Thu Dec 21 00:00:00 EST 2017
Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding.
Blood
Belderbos ME,Koster T,Ausema B,Jacobs S,Sowdagar S,Zwart E,de Bont E,de Haan G,Bystrykh LV
Thu Jun 15 00:00:00 EDT 2017
Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.
The Journal of experimental medicine
Abolhassani H,Edwards ES,Ikinciogullari A,Jing H,Borte S,Buggert M,Du L,Matsuda-Lennikov M,Romano R,Caridha R,Bade S,Zhang Y,Frederiksen J,Fang M,Bal SK,Haskologlu S,Dogu F,Tacyildiz N,Matthews HF,McElwee JJ,Gostick E,Price DA,Palendira U,Aghamohammadi A,Boisson B,Rezaei N,Karlsson AC,Lenardo MJ,Casanova JL,Hammarström L,Tangye SG,Su HC,Pan-Hammarström Q
Sun Jan 01 00:00:00 EST 2017
The chromatin accessibility signature of human immune aging stems from CD8+ T cells.
The Journal of experimental medicine
Ucar D,Márquez EJ,Chung CH,Marches R,Rossi RJ,Uyar A,Wu TC,George J,Stitzel ML,Palucka AK,Kuchel GA,Banchereau J
Mon Oct 02 00:00:00 EDT 2017
JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.
Leukemia
Delgado-Martin C,Meyer LK,Huang BJ,Shimano KA,Zinter MS,Nguyen JV,Smith GA,Taunton J,Winter SS,Roderick JR,Kelliher MA,Horton TM,Wood BL,Teachey DT,Hermiston ML
Fri Dec 01 00:00:00 EST 2017
Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells.
Proceedings of the National Academy of Sciences of the United States of America
Ripamonti A,Provasi E,Lorenzo M,De Simone M,Ranzani V,Vangelisti S,Curti S,Bonnal RJP,Pignataro L,Torretta S,Geginat J,Rossetti G,Pagani M,Abrignani S
Tue Nov 28 00:00:00 EST 2017
Curtailed T-cell activation curbs effector differentiation and generates CD8+ T cells with a naturally-occurring memory stem cell phenotype.
European journal of immunology
Zanon V,Pilipow K,Scamardella E,De Paoli F,De Simone G,Price DA,Martinez Usatorre A,Romero P,Mavilio D,Roberto A,Lugli E
Fri Sep 01 00:00:00 EDT 2017
Adaptive from Innate: Human IFN-γ+CD4+ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults.
Journal of immunology (Baltimore, Md. : 1950)
Das A,Rouault-Pierre K,Kamdar S,Gomez-Tourino I,Wood K,Donaldson I,Mein CA,Bonnet D,Hayday AC,Gibbons DL
Fri Sep 01 00:00:00 EDT 2017
Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Schmueck-Henneresse M,Omer B,Shum T,Tashiro H,Mamonkin M,Lapteva N,Sharma S,Rollins L,Dotti G,Reinke P,Volk HD,Rooney CM
Sat Jul 01 00:00:00 EDT 2017
CXCL12-CXCR4 Axis Is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but Not T Lymphoid Generation.
Journal of immunology (Baltimore, Md. : 1950)
Minami H,Nagaharu K,Nakamori Y,Ohishi K,Shimojo N,Kageyama Y,Matsumoto T,Sugimoto Y,Tawara I,Masuya M,Miwa H,Katayama N
Sun Oct 01 00:00:00 EDT 2017
TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1.
Journal of immunology (Baltimore, Md. : 1950)
Sabins NC,Chornoguz O,Leander K,Kaplan F,Carter R,Kinder M,Bachman K,Verona R,Shen S,Bhargava V,Santulli-Marotto S
Fri Dec 15 00:00:00 EST 2017
Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity.
Scientific reports
Park S,Shevlin E,Vedvyas Y,Zaman M,Park S,Hsu YS,Min IM,Jin MM
Mon Oct 30 00:00:00 EDT 2017
Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia.
Oncotarget
Jiang Z,Wu D,Ye W,Weng J,Lai P,Shi P,Guo X,Huang G,Deng Q,Tang Y,Zhao H,Cui S,Lin S,Wang S,Li B,Wu Q,Li Y,Liu P,Pei D,Du X,Yao Y,Li P
200-07 was used in Cell Culture to develop a defined condition for the ex vivo expansion of primary B-ALL cells that is suitable for high-throughput screening of novel compounds.
Tue Dec 05 00:00:00 EST 2017
Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells.
Scientific reports
Nastasi C,Fredholm S,Willerslev-Olsen A,Hansen M,Bonefeld CM,Geisler C,Andersen MH,Ødum N,Woetmann A
Mon Nov 06 00:00:00 EST 2017
Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis.
Nature communications
Al-Mossawi MH,Chen L,Fang H,Ridley A,de Wit J,Yager N,Hammitzsch A,Pulyakhina I,Fairfax BP,Simone D,Yi Y,Bandyopadhyay S,Doig K,Gundle R,Kendrick B,Powrie F,Knight JC,Bowness P
Wed Nov 15 00:00:00 EST 2017
Peripheral human CD4+CD8+ T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15.
Scientific reports
Clénet ML,Gagnon F,Moratalla AC,Viel EC,Arbour N
Thu Sep 14 00:00:00 EDT 2017
Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.
Cell stem cell
Kotini AG,Chang CJ,Chow A,Yuan H,Ho TC,Wang T,Vora S,Solovyov A,Husser C,Olszewska M,Teruya-Feldstein J,Perumal D,Klimek VM,Spyridonidis A,Rampal RK,Silverman L,Reddy EP,Papaemmanuil E,Parekh S,Greenbaum BD,Leslie CS,Kharas MG,Papapetrou EP
200-07 was used in Cell Culture to provide insight into the cellular events demarcating the initiation and progression of myeloid transformation and a new platform for testing genetic and pharmacological interventions.
Thu Mar 02 00:00:00 EST 2017
Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.
Stem cell reports
Li Y,Brauer PM,Singh J,Xhiku S,Yoganathan K,Zúñiga-Pflücker JC,Anderson MK
Tue Sep 12 00:00:00 EDT 2017
Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.
Stem cell reports
Zeng J,Tang SY,Toh LL,Wang S
Tue Dec 12 00:00:00 EST 2017
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing.
Cell
Amabile A,Migliara A,Capasso P,Biffi M,Cittaro D,Naldini L,Lombardo A
Thu Sep 22 00:00:00 EDT 2016
Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.
Immunity
Woytschak J,Keller N,Krieg C,Impellizzieri D,Thompson RW,Wynn TA,Zinkernagel AS,Boyman O
Tue Jul 19 00:00:00 EDT 2016
BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models.
The Journal of clinical investigation
Kagoya Y,Nakatsugawa M,Yamashita Y,Ochi T,Guo T,Anczurowski M,Saso K,Butler MO,Arrowsmith CH,Hirano N
Thu Sep 01 00:00:00 EDT 2016
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America
Gregory MA,D'Alessandro A,Alvarez-Calderon F,Kim J,Nemkov T,Adane B,Rozhok AI,Kumar A,Kumar V,Pollyea DA,Wempe MF,Jordan CT,Serkova NJ,Tan AC,Hansen KC,DeGregori J
Tue Oct 25 00:00:00 EDT 2016
pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences.
Molecular therapy. Nucleic acids
Grier AE,Burleigh S,Sahni J,Clough CA,Cardot V,Choe DC,Krutein MC,Rawlings DJ,Jensen MC,Scharenberg AM,Jacoby K
Tue Apr 19 00:00:00 EDT 2016
Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.
Molecular therapy. Nucleic acids
Romano Ibarra GS,Paul B,Sather BD,Younan PM,Sommer K,Kowalski JP,Hale M,Stoddard B,Jarjour J,Astrakhan A,Kiem HP,Rawlings DJ
Tue Aug 23 00:00:00 EDT 2016
Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.
Journal of immunology (Baltimore, Md. : 1950)
Cuff AO,Robertson FP,Stegmann KA,Pallett LJ,Maini MK,Davidson BR,Male V
Thu Dec 01 00:00:00 EST 2016
A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood.
Journal of immunology (Baltimore, Md. : 1950)
Dan JM,Lindestam Arlehamn CS,Weiskopf D,da Silva Antunes R,Havenar-Daughton C,Reiss SM,Brigger M,Bothwell M,Sette A,Crotty S
Mon Aug 01 00:00:00 EDT 2016
Heparan Sulfate Proteoglycans Promote Telomerase Internalization and MHC Class II Presentation on Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Galaine J,Kellermann G,Guillaume Y,Boidot R,Picard E,Loyon R,Queiroz L,Boullerot L,Beziaud L,Jary M,Mansi L,André C,Lethier L,Ségal-Bendirdjian E,Borg C,Godet Y,Adotévi O
Thu Sep 01 00:00:00 EDT 2016
Immune-system-dependent anti-tumor activity of a plant-derived polyphenol rich fraction in a melanoma mouse model.
Cell death & disease
Gomez-Cadena A,Urueña C,Prieto K,Martinez-Usatorre A,Donda A,Barreto A,Romero P,Fiorentino S
Thu Jun 02 00:00:00 EDT 2016
GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.
Stem cell reports
D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II
Tue Feb 09 00:00:00 EST 2016
Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Nature communications
Serr I,Fürst RW,Achenbach P,Scherm MG,Gökmen F,Haupt F,Sedlmeier EM,Knopff A,Shultz L,Willis RA,Ziegler AG,Daniel C
Tue Mar 15 00:00:00 EDT 2016
BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors.
Cell death & disease
Korfi K,Smith M,Swan J,Somervaille TC,Dhomen N,Marais R
Thu Apr 07 00:00:00 EDT 2016
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Nature communications
Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM
Mon Nov 21 00:00:00 EST 2016
The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling.
The Journal of biological chemistry
Lykken EA,Li QJ
Fri Nov 04 00:00:00 EDT 2016
High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens.
Blood
Wegner J,Hackenberg S,Scholz CJ,Chuvpilo S,Tyrsin D,Matskevich AA,Grigoleit GU,Stevanović S,Hünig T
Thu Jul 09 00:00:00 EDT 2015
T memory stem cells are the hierarchical apex of adult T-cell leukemia.
Blood
Nagai Y,Kawahara M,Hishizawa M,Shimazu Y,Sugino N,Fujii S,Kadowaki N,Takaori-Kondo A
Thu Jun 04 00:00:00 EDT 2015
Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing.
Blood
Leone P,Berardi S,Frassanito MA,Ria R,De Re V,Cicco S,Battaglia S,Ditonno P,Dammacco F,Vacca A,Racanelli V
Thu Sep 17 00:00:00 EDT 2015
Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation.
Blood
Geskin LJ,Viragova S,Stolz DB,Fuschiotti P
Thu Apr 30 00:00:00 EDT 2015
Survivin-specific T cell receptor targets tumor but not T cells.
The Journal of clinical investigation
Arber C,Feng X,Abhyankar H,Romero E,Wu MF,Heslop HE,Barth P,Dotti G,Savoldo B
Thu Jan 01 00:00:00 EST 2015
Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages.
Proceedings of the National Academy of Sciences of the United States of America
McClellan JS,Dove C,Gentles AJ,Ryan CE,Majeti R
Tue Mar 31 00:00:00 EDT 2015
Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.
Proceedings of the National Academy of Sciences of the United States of America
Yin J,Leavenworth JW,Li Y,Luo Q,Xie H,Liu X,Huang S,Yan H,Fu Z,Zhang LY,Zhang L,Hao J,Wu X,Deng X,Roberts CW,Orkin SH,Cantor H,Wang X
Tue Dec 29 00:00:00 EST 2015
Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans.
Aging cell
van der Geest KS,Abdulahad WH,Teteloshvili N,Tete SM,Peters JH,Horst G,Lorencetti PG,Bos NA,Lambeck A,Roozendaal C,Kroesen BJ,Koenen HJ,Joosten I,Brouwer E,Boots AM
Thu Oct 01 00:00:00 EDT 2015
Phase I pilot study of Wilms tumor gene 1 peptide-pulsed dendritic cell vaccination combined with gemcitabine in pancreatic cancer.
Cancer science
Mayanagi S,Kitago M,Sakurai T,Matsuda T,Fujita T,Higuchi H,Taguchi J,Takeuchi H,Itano O,Aiura K,Hamamoto Y,Takaishi H,Okamoto M,Sunamura M,Kawakami Y,Kitagawa Y
Wed Apr 01 00:00:00 EDT 2015
Annexin A3 as a potential target for immunotherapy of liver cancer stem-like cells.
Stem cells (Dayton, Ohio)
Pan QZ,Pan K,Wang QJ,Weng DS,Zhao JJ,Zheng HX,Zhang XF,Jiang SS,Lv L,Tang Y,Li YQ,He J,Liu Q,Chen CL,Zhang HX,Xia JC
Sun Feb 01 00:00:00 EST 2015
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.
Stem cells (Dayton, Ohio)
Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS
Wed Apr 01 00:00:00 EDT 2015
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.
Stem cells (Dayton, Ohio)
Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS
Wed Apr 01 00:00:00 EDT 2015
Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Giannakopoulou E,Lom H,Wedderburn LR
Tue Dec 15 00:00:00 EST 2015
Knowledge, Behavioral, and Sociocultural Factors Related to Human Papillomavirus Infection and Cervical Cancer Screening Among Inner-City Women in Panama.
Journal of community health
Vamos CA,Calvo AE,Daley EM,Giuliano AR,López Castillo H
Tue Dec 01 00:00:00 EST 2015
TFH cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1.
Scientific reports
Allam A,Majji S,Peachman K,Jagodzinski L,Kim J,Ratto-Kim S,Wijayalath W,Merbah M,Kim JH,Michael NL,Alving CR,Casares S,Rao M
Tue Jun 02 00:00:00 EDT 2015
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific reports
Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J
Mon Oct 12 00:00:00 EDT 2015
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific reports
Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J
Mon Oct 12 00:00:00 EDT 2015
Targeted genome editing in human repopulating haematopoietic stem cells.
Nature
Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L
Thu Jun 12 00:00:00 EDT 2014
Targeted genome editing in human repopulating haematopoietic stem cells.
Nature
Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L
Thu Jun 12 00:00:00 EDT 2014
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
Immunity
Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR
Thu Sep 18 00:00:00 EDT 2014
Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15.
Blood
Xu Y,Zhang M,Ramos CA,Durett A,Liu E,Dakhova O,Liu H,Creighton CJ,Gee AP,Heslop HE,Rooney CM,Savoldo B,Dotti G
Thu Jun 12 00:00:00 EDT 2014
Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice.
Blood
Zhang SL,Wang X,Manna S,Zlotoff DA,Bryson JL,Blazar BR,Bhandoola A
Thu Jul 10 00:00:00 EDT 2014
Essential role for autophagy during invariant NKT cell development.
Proceedings of the National Academy of Sciences of the United States of America
Salio M,Puleston DJ,Mathan TS,Shepherd D,Stranks AJ,Adamopoulou E,Veerapen N,Besra GS,Hollander GA,Simon AK,Cerundolo V
Tue Dec 30 00:00:00 EST 2014
Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells.
Proceedings of the National Academy of Sciences of the United States of America
Miller ML,Mashayekhi M,Chen L,Zhou P,Liu X,Michelotti M,Tramontini Gunn N,Powers S,Zhu X,Evaristo C,Alegre ML,Molinero LL
Tue May 20 00:00:00 EDT 2014
Diversity and clonal selection in the human T-cell repertoire.
Proceedings of the National Academy of Sciences of the United States of America
Qi Q,Liu Y,Cheng Y,Glanville J,Zhang D,Lee JY,Olshen RA,Weyand CM,Boyd SD,Goronzy JJ
Tue Sep 09 00:00:00 EDT 2014
5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies.
Blood cancer journal
Gang AO,Frøsig TM,Brimnes MK,Lyngaa R,Treppendahl MB,Grønbæk K,Dufva IH,Straten PT,Hadrup SR
Fri Mar 28 00:00:00 EDT 2014
CD8+ T-cell recognition of a synthetic epitope formed by t-butyl modification.
Immunology
Reid RA,Redman JE,Rizkallah P,Fegan C,Pepper C,Man S
Sun Oct 05 00:00:00 EDT 2014
Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling.
Stem cells (Dayton, Ohio)
Fernandez I,Ooi TP,Roy K
Wed Jan 01 00:00:00 EST 2014
Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells.
Journal of immunology (Baltimore, Md. : 1950)
Bonami RH,Sullivan AM,Case JB,Steinberg HE,Hoek KL,Khan WN,Kendall PL
Sat Feb 15 00:00:00 EST 2014
Autologous tumor vaccine modified with recombinant new castle disease virus expressing IL-7 promotes antitumor immune response.
Journal of immunology (Baltimore, Md. : 1950)
Zhao L,Mei Y,Sun Q,Guo L,Wu Y,Yu X,Hu B,Liu X,Liu H
Tue Jul 15 00:00:00 EDT 2014
Autologous tumor vaccine modified with recombinant new castle disease virus expressing IL-7 promotes antitumor immune response.
Journal of immunology (Baltimore, Md. : 1950)
Zhao L,Mei Y,Sun Q,Guo L,Wu Y,Yu X,Hu B,Liu X,Liu H
Tue Jul 15 00:00:00 EDT 2014
IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation.
Journal of immunology (Baltimore, Md. : 1950)
Morandi F,Di Carlo E,Ferrone S,Petretto A,Pistoia V,Airoldi I
Sat Mar 15 00:00:00 EDT 2014
Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Du MR,Guo PF,Piao HL,Wang SC,Sun C,Jin LP,Tao Y,Li YH,Zhang D,Zhu R,Fu Q,Li DJ
Sat Feb 15 00:00:00 EST 2014
X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women.
Journal of immunology (Baltimore, Md. : 1950)
Laffont S,Rouquié N,Azar P,Seillet C,Plumas J,Aspord C,Guéry JC
Mon Dec 01 00:00:00 EST 2014
X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women.
Journal of immunology (Baltimore, Md. : 1950)
Laffont S,Rouquié N,Azar P,Seillet C,Plumas J,Aspord C,Guéry JC
Mon Dec 01 00:00:00 EST 2014
Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Kim PS,Jochems C,Grenga I,Donahue RN,Tsang KY,Gulley JL,Schlom J,Farsaci B
Sat Mar 15 00:00:00 EDT 2014
Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.
Journal of immunology (Baltimore, Md. : 1950)
Volonté A,Di Tomaso T,Spinelli M,Todaro M,Sanvito F,Albarello L,Bissolati M,Ghirardelli L,Orsenigo E,Ferrone S,Doglioni C,Stassi G,Dellabona P,Staudacher C,Parmiani G,Maccalli C
Wed Jan 01 00:00:00 EST 2014
Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand.
Cell death & disease
Nazzal D,Gradolatto A,Truffault F,Bismuth J,Berrih-Aknin S
Thu Sep 11 00:00:00 EDT 2014
High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.
Scientific reports
Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ
Wed Apr 23 00:00:00 EDT 2014
Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.
Blood
Wölfl M,Schwinn S,Yoo YE,Reß ML,Braun M,Chopra M,Schreiber SC,Ayala VI,Ohlen C,Eyrich M,Beilhack A,Schlegel PG
Thu Aug 15 00:00:00 EDT 2013
Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.
Blood
Mace EM,Hsu AP,Monaco-Shawver L,Makedonas G,Rosen JB,Dropulic L,Cohen JI,Frenkel EP,Bagwell JC,Sullivan JL,Biron CA,Spalding C,Zerbe CS,Uzel G,Holland SM,Orange JS
Thu Apr 04 00:00:00 EDT 2013
Notch controls generation and function of human effector CD8+ T cells.
Blood
Kuijk LM,Verstege MI,Rekers NV,Bruijns SC,Hooijberg E,Roep BO,de Gruijl TD,van Kooyk Y,Unger WW
Thu Apr 04 00:00:00 EDT 2013
In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.
Blood
Amabile G,Welner RS,Nombela-Arrieta C,D'Alise AM,Di Ruscio A,Ebralidze AK,Kraytsberg Y,Ye M,Kocher O,Neuberg DS,Khrapko K,Silberstein LE,Tenen DG
Thu Feb 21 00:00:00 EST 2013
In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.
Blood
Amabile G,Welner RS,Nombela-Arrieta C,D'Alise AM,Di Ruscio A,Ebralidze AK,Kraytsberg Y,Ye M,Kocher O,Neuberg DS,Khrapko K,Silberstein LE,Tenen DG
Thu Feb 21 00:00:00 EST 2013
Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.
Blood
Miyazaki Y,Fujiwara H,Asai H,Ochi F,Ochi T,Azuma T,Ishida T,Okamoto S,Mineno J,Kuzushima K,Shiku H,Yasukawa M
Thu Jun 13 00:00:00 EDT 2013
CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.
Blood
Casucci M,Nicolis di Robilant B,Falcone L,Camisa B,Norelli M,Genovese P,Gentner B,Gullotta F,Ponzoni M,Bernardi M,Marcatti M,Saudemont A,Bordignon C,Savoldo B,Ciceri F,Naldini L,Dotti G,Bonini C,Bondanza A
Thu Nov 14 00:00:00 EST 2013
Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia.
Blood
Koss B,Morrison J,Perciavalle RM,Singh H,Rehg JE,Williams RT,Opferman JT
Thu Aug 29 00:00:00 EDT 2013
Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia.
Blood
Koss B,Morrison J,Perciavalle RM,Singh H,Rehg JE,Williams RT,Opferman JT
Thu Aug 29 00:00:00 EDT 2013
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.
Blood
Cieri N,Camisa B,Cocchiarella F,Forcato M,Oliveira G,Provasi E,Bondanza A,Bordignon C,Peccatori J,Ciceri F,Lupo-Stanghellini MT,Mavilio F,Mondino A,Bicciato S,Recchia A,Bonini C
Thu Jan 24 00:00:00 EST 2013
Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo.
PLoS pathogens
Introini A,Vanpouille C,Lisco A,Grivel JC,Margolis L
Fri Feb 01 00:00:00 EST 2013
Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo.
PLoS pathogens
Introini A,Vanpouille C,Lisco A,Grivel JC,Margolis L
Fri Feb 01 00:00:00 EST 2013
Differential response of regulatory and conventional CD4⁺ lymphocytes to CD3 engagement: clues to a possible mechanism of anti-CD3 action?
Journal of immunology (Baltimore, Md. : 1950)
Li L,Nishio J,van Maurik A,Mathis D,Benoist C
Tue Oct 01 00:00:00 EDT 2013
Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950)
Tallerico R,Todaro M,Di Franco S,Maccalli C,Garofalo C,Sottile R,Palmieri C,Tirinato L,Pangigadde PN,La Rocca R,Mandelboim O,Stassi G,Di Fabrizio E,Parmiani G,Moretta A,Dieli F,Kärre K,Carbone E
Fri Mar 01 00:00:00 EST 2013
Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Imai K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y
Sat Jun 15 00:00:00 EDT 2013
Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory.
Journal of immunology (Baltimore, Md. : 1950)
Choi YS,Yang JA,Yusuf I,Johnston RJ,Greenbaum J,Peters B,Crotty S
Mon Apr 15 00:00:00 EDT 2013
B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Henry-Bonami RA,Williams JM,Rachakonda AB,Karamali M,Kendall PL,Thomas JW
Sat Jun 15 00:00:00 EDT 2013
Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.
PloS one
Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK
Wed Jul 03 00:00:00 EDT 2013
Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.
PloS one
Magnusson M,Sierra MI,Sasidharan R,Prashad SL,Romero M,Saarikoski P,Van Handel B,Huang A,Li X,Mikkola HK
Wed Jul 03 00:00:00 EDT 2013
IRX-2, a novel immunotherapeutic, enhances functions of human dendritic cells.
PloS one
Schilling B,Harasymczuk M,Schuler P,Egan J,Ferrone S,Whiteside TL
Fri Sep 06 00:00:00 EDT 2013
Functional heterogeneity of human effector CD8+ T cells.
Blood
Takata H,Naruto T,Takiguchi M
Thu Feb 09 00:00:00 EST 2012
The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.
Blood
Karrich JJ,Balzarolo M,Schmidlin H,Libouban M,Nagasawa M,Gentek R,Kamihira S,Maeda T,Amsen D,Wolkers MC,Blom B
Thu May 31 00:00:00 EDT 2012
The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.
Blood
Karrich JJ,Balzarolo M,Schmidlin H,Libouban M,Nagasawa M,Gentek R,Kamihira S,Maeda T,Amsen D,Wolkers MC,Blom B
Thu May 31 00:00:00 EDT 2012
Mast cells play a protumorigenic role in primary cutaneous lymphoma.
Blood
Rabenhorst A,Schlaak M,Heukamp LC,Förster A,Theurich S,von Bergwelt-Baildon M,Büttner R,Kurschat P,Mauch C,Roers A,Hartmann K
Thu Sep 06 00:00:00 EDT 2012
IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa.
Blood
Cimbro R,Vassena L,Arthos J,Cicala C,Kehrl JH,Park C,Sereti I,Lederman MM,Fauci AS,Lusso P
Thu Sep 27 00:00:00 EDT 2012
PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.
Blood
van de Laar L,van den Bosch A,Boonstra A,Binda RS,Buitenhuis M,Janssen HL,Coffer PJ,Woltman AM
Thu Dec 13 00:00:00 EST 2012
PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.
Blood
van de Laar L,van den Bosch A,Boonstra A,Binda RS,Buitenhuis M,Janssen HL,Coffer PJ,Woltman AM
Thu Dec 13 00:00:00 EST 2012
Zebrafish screen identifies novel compound with selective toxicity against leukemia.
Blood
Ridges S,Heaton WL,Joshi D,Choi H,Eiring A,Batchelor L,Choudhry P,Manos EJ,Sofla H,Sanati A,Welborn S,Agarwal A,Spangrude GJ,Miles RR,Cox JE,Frazer JK,Deininger M,Balan K,Sigman M,Müschen M,Perova T,Johnson R,Montpellier B,Guidos CJ,Jones DA,Trede NS
Thu Jun 14 00:00:00 EDT 2012
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.
Blood
Chang KH,Sanchez-Aguilera A,Shen S,Sengupta A,Madhu MN,Ficker AM,Dunn SK,Kuenzi AM,Arnett JL,Santho RA,Agirre X,Perentesis JP,Deininger MW,Zheng Y,Bustelo XR,Williams DA,Cancelas JA
Thu Jul 26 00:00:00 EDT 2012
IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity.
The Journal of clinical investigation
Liu D,Song L,Wei J,Courtney AN,Gao X,Marinova E,Guo L,Heczey A,Asgharzadeh S,Kim E,Dotti G,Metelitsa LS
Fri Jun 01 00:00:00 EDT 2012
Early ontogenic origin of the hematopoietic stem cell lineage.
Proceedings of the National Academy of Sciences of the United States of America
Tanaka Y,Hayashi M,Kubota Y,Nagai H,Sheng G,Nishikawa S,Samokhvalov IM
Tue Mar 20 00:00:00 EDT 2012
Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice.
Stem cells (Dayton, Ohio)
Reimann C,Six E,Dal-Cortivo L,Schiavo A,Appourchaux K,Lagresle-Peyrou C,de Chappedelaine C,Ternaux B,Coulombel L,Beldjord K,Cavazzana-Calvo M,Andre-Schmutz I
Wed Aug 01 00:00:00 EDT 2012
Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.
Journal of immunology (Baltimore, Md. : 1950)
Lissauer D,Piper K,Goodyear O,Kilby MD,Moss PA
Sun Jul 15 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
Adipocyte-derived soluble factor(s) inhibits early stages of B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Bilwani FA,Knight KL
Thu Nov 01 00:00:00 EDT 2012
IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950)
Paine A,Kirchner H,Immenschuh S,Oelke M,Blasczyk R,Eiz-Vesper B
Wed Feb 15 00:00:00 EST 2012
The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950)
Kreft KL,Verbraak E,Wierenga-Wolf AF,van Meurs M,Oostra BA,Laman JD,Hintzen RQ
Wed Feb 15 00:00:00 EST 2012
Evidence for involvement of Th17 type responses in post kala azar dermal leishmaniasis (PKDL).
PLoS neglected tropical diseases
Katara GK,Ansari NA,Singh A,Ramesh V,Salotra P
Fri Sep 28 00:00:00 EDT 2012
Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma.
BMC cancer
Blix ES,Irish JM,Husebekk A,Delabie J,Forfang L,Tierens AM,Myklebust JH,Kolstad A
Tue Oct 16 00:00:00 EDT 2012
Autophagy creates a CTL epitope that mimics tumor-associated antigens.
PloS one
Demachi-Okamura A,Torikai H,Akatsuka Y,Miyoshi H,Yoshimori T,Kuzushima K
Wed May 01 00:00:00 EDT 2013
Functional Differences between Human NKp44(-) and NKp44(+) RORC(+) Innate Lymphoid Cells.
Frontiers in immunology
Hoorweg K,Peters CP,Cornelissen F,Aparicio-Domingo P,Papazian N,Kazemier G,Mjösberg JM,Spits H,Cupedo T
Thu Aug 23 00:00:00 EDT 2012
Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.
BMC immunology
Patel ES,Okada S,Hachey K,Yang LJ,Durum SK,Moreb JS,Chang LJ
Thu Aug 16 00:00:00 EDT 2012
Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.
BMC immunology
Patel ES,Okada S,Hachey K,Yang LJ,Durum SK,Moreb JS,Chang LJ
Thu Aug 16 00:00:00 EDT 2012
MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.
PloS one
Testa JS,Shetty V,Hafner J,Nickens Z,Kamal S,Sinnathamby G,Philip R
Wed Apr 24 00:00:00 EDT 2013
Characterization of T-cell responses against IκBα in cancer patients.
Oncoimmunology
Munir S,Frøsig TM,Hansen M,Svane IM,Andersen MH
Thu Nov 01 00:00:00 EDT 2012
Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.
The Journal of biological chemistry
Mitra A,Ross JA,Rodriguez G,Nagy ZS,Wilson HL,Kirken RA
Fri May 11 00:00:00 EDT 2012
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.
Nature
Duy C,Hurtz C,Shojaee S,Cerchietti L,Geng H,Swaminathan S,Klemm L,Kweon SM,Nahar R,Braig M,Park E,Kim YM,Hofmann WK,Herzog S,Jumaa H,Koeffler HP,Yu JJ,Heisterkamp N,Graeber TG,Wu H,Ye BH,Melnick A,Müschen M
Thu May 19 00:00:00 EDT 2011
Activation of STAT6 by STING is critical for antiviral innate immunity.
Cell
Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z
Fri Oct 14 00:00:00 EDT 2011
Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.
Blood
Janikashvili N,LaCasse CJ,Larmonier C,Trad M,Herrell A,Bustamante S,Bonnotte B,Har-Noy M,Larmonier N,Katsanis E
Thu Feb 03 00:00:00 EST 2011
Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.
Blood
Bluteau D,Gilles L,Hilpert M,Antony-Debré I,James C,Debili N,Camara-Clayette V,Wagner-Ballon O,Cordette-Lagarde V,Robert T,Ripoche H,Gonin P,Swierczek S,Prchal J,Vainchenker W,Favier R,Raslova H
Thu Dec 08 00:00:00 EST 2011
IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.
Blood
Bondanza A,Hambach L,Aghai Z,Nijmeijer B,Kaneko S,Mastaglio S,Radrizzani M,Fleischhauer K,Ciceri F,Bordignon C,Bonini C,Goulmy E
Thu Jun 16 00:00:00 EDT 2011
Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.
Blood
Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ
Thu Mar 17 00:00:00 EDT 2011
Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators.
Blood
Sørensen RB,Hadrup SR,Svane IM,Hjortsø MC,Thor Straten P,Andersen MH
Thu Feb 17 00:00:00 EST 2011
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood
Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E
Thu Jan 06 00:00:00 EST 2011
Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.
Blood
Park YP,Choi SC,Kiesler P,Gil-Krzewska A,Borrego F,Weck J,Krzewski K,Coligan JE
Thu Sep 15 00:00:00 EDT 2011
Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells.
PLoS pathogens
Bosque A,Famiglietti M,Weyrich AS,Goulston C,Planelles V
Sat Oct 01 00:00:00 EDT 2011
Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors.
Cancer immunology, immunotherapy : CII
Andersen RS,Sørensen RB,Ritter C,Svane IM,Becker JC,thor Straten P,Andersen MH
Tue Feb 01 00:00:00 EST 2011
Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Zhan Y,Zhang Y,Gray D,Carrington EM,Bouillet P,Ko HJ,O'Reilly L,Wicks IP,Strasser A,Lew AM
Mon Aug 15 00:00:00 EDT 2011
Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim.
Journal of immunology (Baltimore, Md. : 1950)
Kurtulus S,Tripathi P,Moreno-Fernandez ME,Sholl A,Katz JD,Grimes HL,Hildeman DA
Sun May 15 00:00:00 EDT 2011
Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Feng N,Vegh P,Rothenberg EV,Yui MA
Sat Jan 15 00:00:00 EST 2011
Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Muralidharan S,Hanley PJ,Liu E,Chakraborty R,Bollard C,Shpall E,Rooney C,Savoldo B,Rodgers J,Dotti G
Tue Nov 15 00:00:00 EST 2011
Host-based Th2 cell therapy for prolongation of cardiac allograft viability.
PloS one
Amarnath S,Chen H,Foley JE,Costanzo CM,Sennesh JD,Solomon MA,Fowler DH
Fri Apr 29 00:00:00 EDT 2011
Generation of multivirus-specific T cells to prevent/treat viral infections after allogeneic hematopoietic stem cell transplant.
Journal of visualized experiments : JoVE
Gerdemann U,Vera JF,Rooney CM,Leen AM
Fri May 27 00:00:00 EDT 2011
Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells.
PloS one
Sjeklocha LM,Park CW,Wong PY,Roney MJ,Belcher JD,Kaufman DS,Vercellotti GM,Hebbel RP,Steer CJ
Mon May 21 00:00:00 EDT 2012
Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature.
BMC immunology
Awong G,Herer E,La Motte-Mohs RN,Zúñiga-Pflücker JC
Wed Mar 23 00:00:00 EDT 2011
IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.
PloS one
Sammicheli S,Dang VP,Ruffin N,Pham HT,Lantto R,Vivar N,Chiodi F,Rethi B
Mon Aug 27 00:00:00 EDT 2012
Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
PloS one
Yu Y,Zitzner JR,Houlihan J,Herrera N,Xu L,Miller J,Mathew JM,Tambur AR,Luo X
Mon Aug 27 00:00:00 EDT 2012
Day-4 myeloid dendritic cells pulsed with whole tumor lysate are highly immunogenic and elicit potent anti-tumor responses.
PloS one
Chiang CL,Hagemann AR,Leskowitz R,Mick R,Garrabrant T,Czerniecki BJ,Kandalaft LE,Powell DJ,Coukos G
Mon Aug 27 00:00:00 EDT 2012
A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2.
Blood
Sivori S,Falco M,Carlomagno S,Romeo E,Soldani C,Bensussan A,Viola A,Moretta L,Moretta A
Thu Sep 09 00:00:00 EDT 2010
Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation.
Blood
Birkholz K,Schwenkert M,Kellner C,Gross S,Fey G,Schuler-Thurner B,Schuler G,Schaft N,Dörrie J
Thu Sep 30 00:00:00 EDT 2010
IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells.
Blood
Henriques CM,Rino J,Nibbs RJ,Graham GJ,Barata JT
Thu Apr 22 00:00:00 EDT 2010
Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma.
Blood
Racanelli V,Leone P,Frassanito MA,Brunetti C,Perosa F,Ferrone S,Dammacco F
Thu Feb 11 00:00:00 EST 2010
Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans.
Blood
Guo PF,Du MR,Wu HX,Lin Y,Jin LP,Li DJ
Thu Sep 23 00:00:00 EDT 2010
CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.
The Journal of clinical investigation
Peperzak V,Xiao Y,Veraar EA,Borst J
Fri Jan 01 00:00:00 EST 2010
Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity.
Proceedings of the National Academy of Sciences of the United States of America
Cella M,Otero K,Colonna M
Tue Jun 15 00:00:00 EDT 2010
Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.
PLoS pathogens
Joosten SA,van Meijgaarden KE,van Weeren PC,Kazi F,Geluk A,Savage ND,Drijfhout JW,Flower DR,Hanekom WA,Klein MR,Ottenhoff TH
Fri Feb 26 00:00:00 EST 2010
Fine-scale staging of T cell lineage commitment in adult mouse thymus.
Journal of immunology (Baltimore, Md. : 1950)
Yui MA,Feng N,Rothenberg EV
Thu Jul 01 00:00:00 EDT 2010
A single TCR alpha-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950)
Liang X,Weigand LU,Schuster IG,Eppinger E,van der Griendt JC,Schub A,Leisegang M,Sommermeyer D,Anderl F,Han Y,Ellwart J,Moosmann A,Busch DH,Uckert W,Peschel C,Krackhardt AM
Mon Feb 01 00:00:00 EST 2010
Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.
Journal of immunology (Baltimore, Md. : 1950)
Lee SH,Yun S,Piao ZH,Jeong M,Kim DO,Jung H,Lee J,Kim MJ,Kim MS,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I
Thu Jul 15 00:00:00 EDT 2010
An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Martin JF,Perry JS,Jakhete NR,Wang X,Bielekova B
Thu Jul 15 00:00:00 EDT 2010
STAT5 is critical to maintain effector CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Tripathi P,Kurtulus S,Wojciechowski S,Sholl A,Hoebe K,Morris SC,Finkelman FD,Grimes HL,Hildeman DA
Sun Aug 15 00:00:00 EDT 2010
Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo.
Gene therapy
Centlivre M,Zhou X,Pouw SM,Weijer K,Kleibeuker W,Das AT,Blom B,Seppen J,Berkhout B,Legrand N
Fri Jan 01 00:00:00 EST 2010
Impact of γ-chain cytokines on EBV-specific T cell cultures.
Journal of translational medicine
Merlo A,Turrini R,Trento C,Zanovello P,Dolcetti R,Rosato A
Mon Nov 22 00:00:00 EST 2010
Hepatic interleukin-7 expression regulates T cell responses.
Immunity
Sawa Y,Arima Y,Ogura H,Kitabayashi C,Jiang JJ,Fukushima T,Kamimura D,Hirano T,Murakami M
Fri Mar 20 00:00:00 EDT 2009
T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells.
Blood
Ahlen MT,Husebekk A,Killie MK,Skogen B,Stuge TB
Thu Apr 16 00:00:00 EDT 2009
Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells.
Blood
Figueiredo C,Wittmann M,Wang D,Dressel R,Seltsam A,Blasczyk R,Eiz-Vesper B
Thu Mar 26 00:00:00 EDT 2009
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.
Blood
Xue X,Huang X,Nodland SE,Mátés L,Ma L,Izsvák Z,Ivics Z,LeBien TW,McIvor RS,Wagner JE,Zhou X
Thu Aug 13 00:00:00 EDT 2009
Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.
Blood
Awong G,Herer E,Surh CD,Dick JE,La Motte-Mohs RN,Zúñiga-Pflücker JC
Thu Jul 30 00:00:00 EDT 2009
IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes.
Blood
Kaneko S,Mastaglio S,Bondanza A,Ponzoni M,Sanvito F,Aldrighetti L,Radrizzani M,La Seta-Catamancio S,Provasi E,Mondino A,Nagasawa T,Fleischhauer K,Russo V,Traversari C,Ciceri F,Bordignon C,Bonini C
Thu Jan 29 00:00:00 EST 2009
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood
Eberhard Y,McDermott SP,Wang X,Gronda M,Venugopal A,Wood TE,Hurren R,Datti A,Batey RA,Wrana J,Antholine WE,Dick JE,Schimmer AD
Thu Oct 01 00:00:00 EDT 2009
Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition.
Proceedings of the National Academy of Sciences of the United States of America
Nicholls S,Piper KP,Mohammed F,Dafforn TR,Tenzer S,Salim M,Mahendra P,Craddock C,van Endert P,Schild H,Cobbold M,Engelhard VH,Moss PA,Willcox BE
Tue Mar 10 00:00:00 EDT 2009
IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death.
Cell death and differentiation
Czystowska M,Han J,Szczepanski MJ,Szajnik M,Quadrini K,Brandwein H,Hadden JW,Signorelli K,Whiteside TL
Fri May 01 00:00:00 EDT 2009
Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells.
Cancer gene therapy
Symes JC,Siatskas C,Fowler DH,Medin JA
Fri May 01 00:00:00 EDT 2009
CD40 regulates human dendritic cell-derived IL-7 production that, in turn, contributes to CD8(+) T-cell antigen-specific expansion.
Immunology and cell biology
Carreno BM,Becker-Hapak M,Linette GP
Sun Feb 01 00:00:00 EST 2009
Functional silencing is initiated and maintained in immature anti-insulin B cells.
Journal of immunology (Baltimore, Md. : 1950)
Henry RA,Acevedo-Suárez CA,Thomas JW
Sun Mar 15 00:00:00 EDT 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 EDT 2009
Evidence for the specificity for platelet HPA-1a alloepitope and the presenting HLA-DR52a of diverse antigen-specific helper T cell clones from alloimmunized mothers.
Journal of immunology (Baltimore, Md. : 1950)
Rayment R,Kooij TW,Zhang W,Siebold C,Murphy MF,Allen D,Willcox N,Roberts DJ
Wed Jul 01 00:00:00 EDT 2009
Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model.
Gene therapy
ter Brake O,Legrand N,von Eije KJ,Centlivre M,Spits H,Weijer K,Blom B,Berkhout B
Thu Jan 01 00:00:00 EST 2009
A modified epitope identified for generation and monitoring of PSA-specific T cells in patients on early phases of PSA-based immunotherapeutic protocols.
Vaccine
Lundberg K,Roos AK,Pavlenko M,Leder C,Wehrum D,Guevara-Patiño J,Andersen RS,Pisa P
Wed Mar 04 00:00:00 EST 2009
Long-term culture of primary human lymphoblastic leukemia cells in the absence of serum or hematopoietic growth factors.
Experimental hematology
Nijmeijer BA,Szuhai K,Goselink HM,van Schie ML,van der Burg M,de Jong D,Marijt EW,Ottmann OG,Willemze R,Falkenburg JH
Sun Mar 01 00:00:00 EST 2009
Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7.
The Journal of biological chemistry
Sakaguchi M,Kataoka K,Abarzua F,Tanimoto R,Watanabe M,Murata H,Than SS,Kurose K,Kashiwakura Y,Ochiai K,Nasu Y,Kumon H,Huh NH
Fri May 22 00:00:00 EDT 2009
Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7.
The Journal of biological chemistry
Sakaguchi M,Kataoka K,Abarzua F,Tanimoto R,Watanabe M,Murata H,Than SS,Kurose K,Kashiwakura Y,Ochiai K,Nasu Y,Kumon H,Huh NH
Fri May 22 00:00:00 EDT 2009
Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells.
PloS one
Vercoulen Y,Wehrens EJ,van Teijlingen NH,de Jager W,Beekman JM,Prakken BJ
Fri Sep 25 00:00:00 EDT 2009
The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase.
PloS one
Sørensen RB,Berge-Hansen L,Junker N,Hansen CA,Hadrup SR,Schumacher TN,Svane IM,Becker JC,thor Straten P,Andersen MH
Mon Sep 07 00:00:00 EDT 2009
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
The Journal of clinical investigation
Skowera A,Ellis RJ,Varela-Calviño R,Arif S,Huang GC,Van-Krinks C,Zaremba A,Rackham C,Allen JS,Tree TI,Zhao M,Dayan CM,Sewell AK,Unger WW,Drijfhout JW,Ossendorp F,Roep BO,Peakman M
Wed Oct 01 00:00:00 EDT 2008
Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.
Clinical cancer research : an official journal of the American Association for Cancer Research
Su Z,Frye C,Bae KM,Kelley V,Vieweg J
Wed Oct 01 00:00:00 EDT 2008
T cell responses to whole SARS coronavirus in humans.
Journal of immunology (Baltimore, Md. : 1950)
Li CK,Wu H,Yan H,Ma S,Wang L,Zhang M,Tang X,Temperton NJ,Weiss RA,Brenchley JM,Douek DC,Mongkolsapaya J,Tran BH,Lin CL,Screaton GR,Hou JL,McMichael AJ,Xu XN
Wed Oct 15 00:00:00 EDT 2008
In vitro human T cell development directed by notch-ligand interactions.
Methods in molecular biology (Clifton, N.J.)
Awong G,La Motte-Mohs RN,Zúñiga-Pflücker JC
200-07 was used in Cell Culture to outline a simple in vitro protocol for generating large numbers of human T-lineage cells from umbilical cord blood (CB)- derived hematopoietic stem cells (HSCs) using a bone marrow stromal cell line.
Tue Apr 29 00:00:00 EDT 2008
Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T
Sat Sep 15 00:00:00 EDT 2007
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.
Proceedings of the National Academy of Sciences of the United States of America
Bauer A,Villunger A,Labi V,Fischer SF,Strasser A,Wagner H,Schmid RM,Häcker G
Tue Jul 18 00:00:00 EDT 2006
Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.
Journal of immunology (Baltimore, Md. : 1950)
van Beek J,van Meurs M,'t Hart BA,Brok HP,Neal JW,Chatagner A,Harris CL,Omidvar N,Morgan BP,Laman JD,Gasque P
Tue Feb 15 00:00:00 EST 2005
Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor.
The Journal of experimental medicine
Lin L,Gerth AJ,Peng SL
Mon Jul 05 00:00:00 EDT 2004
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research
Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT
Sat Feb 15 00:00:00 EST 2003
Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15.
Blood
Yu H,Fehniger TA,Fuchshuber P,Thiel KS,Vivier E,Carson WE,Caligiuri MA
Sun Nov 15 00:00:00 EST 1998
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hanson MG,Shen S,Wiemelt AP,McMorris FA,Barres BA
Tue Sep 15 00:00:00 EDT 1998