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Invitrogen
Human KCNMA1 (aa 945-961) Synthetic Peptide
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Product Details
PEP-113
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
50 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-113 is a 17 amino acid synthetic peptide whose sequences are derived from amino acids 945-961 of human MaxiK+ alpha protein with a amino-terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): C-T (945)-E-L-V-N-D-T-N-V-Q-F-L-D-Q-D-D-D (961)
PEP-113 may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human Maxi K+ alpha, catalog # PA1-923. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Target Information
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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