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Invitrogen
Human LIPG (aa 34-169) Control Fragment Recombinant Protein
Product Details
RP-88732
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
KLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYS
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (78%), Rat (78%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-82568. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
LIPG (Lipase G, Endohelial type) is an endothelial lipase which is a novel member of the lipoprotein lipase gene family. LIPG is synthesized by endothelial cells and functions at the site of synthesis. LIPG most likely plays a physiological role in modulating lipoprotein metabolism. Overexpressed LIPG has been shown to reduce HDL cholesterol levels, whereas an LIPG deficiency appears to be effective in elevating HDL cholesterol levels in animals. LIPG has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. Also, LIPG is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. LIPG is a carboxyl esterase that hydrolyzes high density lipoproteins, emulsifies triglycerides, is essential for the efficient digestion of dietary fats and can bind to heparin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EDL; Endothelial cell-derived lipase; Endothelial lipase; lipase, endothelial; lipoprotein lipase H; Phospholipase A1; PL
Gene Aliases: EDL; EL; LIPG; PRO719; UNQ387/PRO719
UniProt ID: (Human) Q9Y5X9
Entrez Gene ID: (Human) 9388
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