Product References
Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
Cancer discovery
Fonteneau G,Redding A,Hoag-Lee H,Sim ES,Heinrich S,Gaida MM,Grabocka E
300-27 was used in In vitro experiments to show that stress adaptation via the phase-separation organelles stress granules (SGs) mediates pancreatic ductal adenocarcinoma (PDAC) development.
Fri Aug 05 00:00:00 EDT 2022
Cutting Edge: Intestinal IL-17A Receptor Signaling Specifically Regulates High-Fat Diet-Mediated, Microbiota-Driven Metabolic Disorders.
Journal of immunology (Baltimore, Md. : 1950)
Gaudino SJ,Huang H,Jean-Pierre M,Joshi P,Beaupre M,Kempen C,Wong HT,Kumar P
Fri Oct 15 00:00:00 EDT 2021
The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses.
Nature communications
Deng J,Chen Q,Chen Z,Liang K,Gao X,Wang X,Makota FV,Ong HS,Wan Y,Luo K,Gong D,Yu X,Camuglia S,Zeng Q,Zhou T,Xue F,He J,Wei Y,Xiao F,Ma J,Hill DL,Pierson W,Nguyen THO,Zhou H,Wang Y,Shen W,Sun L,Li Z,Xia Q,Qian K,Ye L,Rockman S,Linterman MA,Kedzierska K,Shen N,Lu L,Yu D
Mon May 24 00:00:00 EDT 2021
Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells.
Cell stem cell
Huang WK,Wong SZH,Pather SR,Nguyen PTT,Zhang F,Zhang DY,Zhang Z,Lu L,Fang W,Chen L,Fernandes A,Su Y,Song H,Ming GL
300-27 was used in Cell Culture to report the generation of ARCOs from human iPSCs to model the development of the human hypothalamic arcuate nucleus.
Thu Sep 02 00:00:00 EDT 2021
Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids.
The Journal of biological chemistry
Iqbal J,Mascareno E,Chua S,Hussain MM
Fri Mar 27 00:00:00 EDT 2020
Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet-Induced Obese Minipigs.
Obesity (Silver Spring, Md.)
Chmielewski A,Hubert T,Descamps A,Mazur D,Daoudi M,Ciofi P,Fontaine C,Caiazzo R,Pattou F,Prevot V,Pigeyre M
Sat Jun 01 00:00:00 EDT 2019
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.
Nature communications
Ziegler JF,Böttcher C,Letizia M,Yerinde C,Wu H,Freise I,Rodriguez-Sillke Y,Stoyanova AK,Kreis ME,Asbach P,Kunkel D,Priller J,Anagnostopoulos I,Kühl AA,Miehle K,Stumvoll M,Tran F,Fredrich B,Forster M,Franke A,Bojarski C,Glauben R,Löscher BS,Siegmund B,Weidinger C
Tue Dec 10 00:00:00 EST 2019
Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses.
Cell stem cell
Rajamani U,Gross AR,Hjelm BE,Sequeira A,Vawter MP,Tang J,Gangalapudi V,Wang Y,Andres AM,Gottlieb RA,Sareen D
300-27 was used in Cell Culture to investigate hypothalamic neurons in obesity via human induced pluripotent stem cells.
Thu May 03 00:00:00 EDT 2018
9c11tCLA modulates 11t18:1 and 9t18:1 induced inflammations differently in human umbilical vein endothelial cells.
Scientific reports
Li J,Hu SB,He YM,Zhuo CF,Zhou RL,Chen F,Li HY,Deng ZY
Wed Jan 24 00:00:00 EST 2018
Differentiation of hypothalamic-like neurons from human pluripotent stem cells.
The Journal of clinical investigation
Wang L,Meece K,Williams DJ,Lo KA,Zimmer M,Heinrich G,Martin Carli J,Leduc CA,Sun L,Zeltser LM,Freeby M,Goland R,Tsang SH,Wardlaw SL,Egli D,Leibel RL
Sun Feb 01 00:00:00 EST 2015
Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans.
Immunity & ageing : I & A
Gupta S,Agrawal S,Gollapudi S
Wed Jan 23 00:00:00 EST 2013
The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion.
PloS one
Spinnler R,Gorski T,Stolz K,Schuster S,Garten A,Beck-Sickinger AG,Engelse MA,de Koning EJ,Körner A,Kiess W,Maedler K
Fri Aug 02 00:00:00 EDT 2013
The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion.
PloS one
Spinnler R,Gorski T,Stolz K,Schuster S,Garten A,Beck-Sickinger AG,Engelse MA,de Koning EJ,Körner A,Kiess W,Maedler K
Fri Aug 02 00:00:00 EDT 2013
Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway.
Journal of clinical immunology
Agrawal S,Gollapudi S,Su H,Gupta S
Wed Jun 01 00:00:00 EDT 2011
Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells.
PloS one
Garonna E,Botham KM,Birdsey GM,Randi AM,Gonzalez-Perez RR,Wheeler-Jones CP
Mon Apr 18 00:00:00 EDT 2011
Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LbetaT2 gonadotropes.
Molecular and cellular endocrinology
Avelino-Cruz JE,Flores A,Cebada J,Mellon PL,Felix R,Monjaraz E
300-27 was used in Cell Culture to investigate the role of GnRH and leptin.
Tue Jan 27 00:00:00 EST 2009
Effects of intranasal administration of a leptin-secreting Lactococcus lactis recombinant on food intake, body weight, and immune response of mice.
Applied and environmental microbiology
Bermúdez-Humarán LG,Nouaille S,Zilberfarb V,Corthier G,Gruss A,Langella P,Issad T
Wed Aug 01 00:00:00 EDT 2007
Disparate mesenchyme-lineage tendencies in mesenchymal stem cells from human bone marrow and umbilical cord blood.
Stem cells (Dayton, Ohio)
Chang YJ,Shih DT,Tseng CP,Hsieh TB,Lee DC,Hwang SM
Wed Mar 01 00:00:00 EST 2006
Leptin enhances feeding suppression and neural activation produced by systemically administered bombesin.
American journal of physiology. Regulatory, integrative and comparative physiology
Ladenheim EE,Emond M,Moran TH
Mon Aug 01 00:00:00 EDT 2005
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
The Journal of clinical investigation
Kubota N,Terauchi Y,Tobe K,Yano W,Suzuki R,Ueki K,Takamoto I,Satoh H,Maki T,Kubota T,Moroi M,Okada-Iwabu M,Ezaki O,Nagai R,Ueta Y,Kadowaki T,Noda T
Fri Oct 01 00:00:00 EDT 2004
Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.
Proceedings of the National Academy of Sciences of the United States of America
Maedler K,Sergeev P,Ehses JA,Mathe Z,Bosco D,Berney T,Dayer JM,Reinecke M,Halban PA,Donath MY
Tue May 25 00:00:00 EDT 2004
Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha.
American journal of physiology. Endocrinology and metabolism
Bruce CR,Dyck DJ
Fri Oct 01 00:00:00 EDT 2004
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size.
American journal of physiology. Regulatory, integrative and comparative physiology
Blevins JE,Schwartz MW,Baskin DG
Thu Jul 01 00:00:00 EDT 2004
Feeding and temperature responses to intravenous leptin infusion are differential predictors of obesity in rats.
American journal of physiology. Regulatory, integrative and comparative physiology
Ruffin MP,Adage T,Kuipers F,Strubbe JH,Scheurink AJ,van Dijk G
Thu Apr 01 00:00:00 EST 2004
Leptin induces the hepatic high density lipoprotein receptor scavenger receptor B type I (SR-BI) but not cholesterol 7alpha-hydroxylase (Cyp7a1) in leptin-deficient (ob/ob) mice.
The Journal of biological chemistry
Lundåsen T,Liao W,Angelin B,Rudling M
Fri Oct 31 00:00:00 EST 2003
Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers.
The Journal of biological chemistry
Couturier C,Jockers R
Fri Jul 18 00:00:00 EDT 2003
Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers.
The Journal of biological chemistry
Couturier C,Jockers R
Fri Jul 18 00:00:00 EDT 2003
Interleukin-6-deficient mice develop mature-onset obesity.
Nature medicine
Wallenius V,Wallenius K,Ahrén B,Rudling M,Carlsten H,Dickson SL,Ohlsson C,Jansson JO
Tue Jan 01 00:00:00 EST 2002
Elevated serum leptin in AEDS.
Allergy
Kimata H
Fri Feb 01 00:00:00 EST 2002
Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.
The Journal of biological chemistry
Tobe K,Suzuki R,Aoyama M,Yamauchi T,Kamon J,Kubota N,Terauchi Y,Matsui J,Akanuma Y,Kimura S,Tanaka J,Abe M,Ohsumi J,Nagai R,Kadowaki T
Fri Oct 19 00:00:00 EDT 2001
Placental leptin in normal, diabetic and fetal growth-retarded pregnancies.
Molecular human reproduction
Lea RG,Howe D,Hannah LT,Bonneau O,Hunter L,Hoggard N
Tue Aug 01 00:00:00 EDT 2000
NPY-leptin: opposing effects on appetitive and consummatory ingestive behavior and sexual behavior.
American journal of physiology. Regulatory, integrative and comparative physiology
Ammar AA,Sederholm F,Saito TR,Scheurink AJ,Johnson AE,Södersten P
Thu Jun 01 00:00:00 EDT 2000
Central leptin modulates behavioral and neural responsivity to CCK.
The American journal of physiology
Emond M,Schwartz GJ,Ladenheim EE,Moran TH
Sat May 01 00:00:00 EDT 1999