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Highest antigen sequence indentity to the following orthologs: Mouse (67%), Rat (67%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-65365. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: JCL-1; MAGE tumor antigen CCF; MAGE-D1 antigen; Maged2; melanoma antigen family D, 1; melanoma antigen family D1; Melanoma-associated antigen D1; Neurotrophin receptor-interacting MAGE homolog
Gene Aliases: DLXIN-1; MAGED1; NRAGE; PP2250; PRO2292
UniProt ID: (Human) Q9Y5V3
Entrez Gene ID: (Human) 9500
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