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Highest antigen sequence indentity to the following orthologs: Mouse (87%), Rat (87%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-54555. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2-enoyl thioester reductase; Enoyl-[acyl-carrier-protein] reductase, mitochondrial; homolog of yeast 2-enoyl thioester reductase; HsNrbf-1; mitochondrial 2-enoyl thioester reductase; nuclear receptor binding factor 1; Nuclear receptor-binding factor 1
Gene Aliases: CGI-63; FASN2B; MECR; NBRF1; NRBF1
UniProt ID: (Human) Q9BV79
Entrez Gene ID: (Human) 51102
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