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Invitrogen
Human MYO18A (aa 1340-1436) Control Fragment Recombinant Protein
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Product Details
RP-92099
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
MEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLT
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (95%), Rat (95%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-54041. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
MYO18A may link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 12 kDa TGF-beta-1-induced antiapoptotic factor; KIAA0216; MAJN; molecule associated with Jak-3 N-terminal; Molecule associated with JAK3 N-terminus; myosin 18A; Myosin containing a PDZ domain; myosin containing PDZ domain; myosin; SP-R210aS; SP-A receptor SP-R210 short isoform; Putative TGFB1-induced anti-apoptotic factor 1; SP-A receptor subunit SP-R210 alphaS; SP-R210; Surfactant protein receptor SP-R210; TGF-beta-1-induced antiapoptotic factor 1; TGFB1-induced anti-apoptotic factor 1; Unconventional myosin-XVIIIa; unnamed protein product
Gene Aliases: CD245; KIAA0216; MAJN; MYO18A; MYSPDZ; SP-R210; SPR210; TIAF1
UniProt ID: (Human) Q92614
Entrez Gene ID: (Human) 399687
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