Product References
Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.
Nature communications
Chen Y,Chen L,Wu X,Zhao Y,Wang Y,Jiang D,Liu X,Zhou T,Li S,Wei Y,Liu Y,Hu C,Zhou B,Qin J,Ying H,Ding Q
300-10 was used in In vitro experiments to identify an epigenetic mechanism by which the early phase lipid redistribution from adipose tissue to liver during regeneration impacts hepatocyte proliferation, and suggest a potential strategy to boost liver regeneration.
Sat Mar 18 00:00:00 EDT 2023
Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging.
Cell reports methods
LaLone V,Aizenshtadt A,Goertz J,Skottvoll FS,Mota MB,You J,Zhao X,Berg HE,Stokowiec J,Yu M,Schwendeman A,Scholz H,Wilson SR,Krauss S,Stevens MM
300-10 was used in In vitro experiments to develop an integrated bioanalytical methodology, qRamanomics, to qualify Raman spectral imaging as a tissue phantom calibrated tool for quantitative spatial chemotyping of major classes of biomolecules.
Mon Apr 24 00:00:00 EDT 2023
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.
Cell stem cell
Gadomski S,Fielding C,García-García A,Korn C,Kapeni C,Ashraf S,Villadiego J,Toro RD,Domingues O,Skepper JN,Michel T,Zimmer J,Sendtner R,Dillon S,Poole KES,Holdsworth G,Sendtner M,Toledo-Aral JJ,De Bari C,McCaskie AW,Robey PG,Méndez-Ferrer S
300-10 was used in Cell Culture to uncover a cholinergic neuro-osteocyte interface that regulates skeletogenesis and skeletal turnover through bone-anabolic effects.
Thu Apr 07 00:00:00 EDT 2022
ATP7B gene therapy of autologous reprogrammed hepatocytes alleviates copper accumulation in a mouse model of Wilson's disease.
Hepatology (Baltimore, Md.)
Cai H,Cheng X,Wang XP
Sat Oct 01 00:00:00 EDT 2022
Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway.
Stem cell research & therapy
Wu H,Tang X,Wang Y,Wang N,Chen Q,Xie J,Liu S,Zhong Z,Qiu Y,Situ P,Zern MA,Wang J,Chen H,Duan Y
300-10 was used in Cell Culture to demonstrate a significant step toward developing the expansion of Human pluripotent stem cells (hPSCs) under 3D suspension condition in large-scale cultures. The study played an important role in controlling the size of hPSC aggregates in 3D suspension culture by inhibiting the expression of ICAM1 coupled with the down-regulation of E-cad through the activation of the Wnt signaling pathway.
Thu May 26 00:00:00 EDT 2022
Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion.
iScience
Zhang Y,Guo A,Lyu C,Bi R,Wu Z,Li W,Zhao P,Niu Y,Na J,Xi JJ,Du Y
Fri Nov 19 00:00:00 EST 2021
MiR-193b-3p-ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes.
Cell death & disease
Huang C,Zhong W,Ren X,Huang X,Li Z,Chen C,Jiang B,Chen Z,Jian X,Yang L,Liu X,Huang H,Shen C,Chen X,Dou X,Yu B
Tue Oct 19 00:00:00 EDT 2021
Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates.
Cell discovery
Chen H,Xia K,Huang W,Li H,Wang C,Ma Y,Chen J,Luo P,Zheng S,Wang J,Wang Y,Dong L,Tan Z,Lai X,Mao FF,Li W,Liang X,Wang T,Xiang AP,Ke Q
Tue Aug 31 00:00:00 EDT 2021
Protocol for automated production of human stem cell derived liver spheres.
STAR protocols
Meseguer-Ripolles J,Kasarinaite A,Lucendo-Villarin B,Hay DC
Fri Jun 18 00:00:00 EDT 2021
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure.
iScience
Meseguer-Ripolles J,Lucendo-Villarin B,Tucker C,Ferreira-Gonzalez S,Homer N,Wang Y,Starkey Lewis PJ,M Toledo E,Mellado-Gomez E,Simpson J,Flint O,Jaiswal H,Beer NL,Karlsen AE,Forbes SJ,Dear JW,Hughes J,Hay DC
Fri Jun 25 00:00:00 EDT 2021
Modeling human hepatic steatosis in pluripotent stem cell-derived hepatocytes.
STAR protocols
Sinton MC,Meseguer-Ripolles J,Lucendo-Villarin B,Drake AJ,Hay DC
300-10 was used in Cell Culture to evaluate hepatocyte-like cell manufacturing from human pluripotent stem cells to study hepatic steatosis.
Fri Jun 18 00:00:00 EDT 2021
Live-cell screening platform using human-induced pluripotent stem cells expressing fluorescence-tagged cytochrome P450 1A1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kim JW,Im I,Kim H,Jeon JS,Kang EH,Jo S,Chun HS,Yoon S,Kim JH,Kim SK,Park HJ
Wed Jul 01 00:00:00 EDT 2020
Generation of multi-cellular human liver organoids from pluripotent stem cells.
Methods in cell biology
Thompson WL,Takebe T
300-10 was used in Cell Culture to demonstrate a protocol utilizing PSC derived 3D human liver organoids as a renewable, reproducible and personalized cell source, thus facilitating disease modeling and mechanistic studies.
Wed Jul 07 00:00:00 EDT 2021
Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives.
Scientific reports
Jo HY,Han HW,Jung I,Ju JH,Park SJ,Moon S,Geum D,Kim H,Park HJ,Kim S,Stacey GN,Koo SK,Park MH,Kim JH
Tue Mar 03 00:00:00 EST 2020
Modulation of hepatitis B virus infection by epidermal growth factor secreted from liver sinusoidal endothelial cells.
Scientific reports
Chen SW,Himeno M,Koui Y,Sugiyama M,Nishitsuji H,Mizokami M,Shimotohno K,Miyajima A,Kido T
Tue Sep 01 00:00:00 EDT 2020
Oncostatin M inhibits differentiation of rat stem Leydig cells in vivo and in vitro.
Journal of cellular and molecular medicine
Wang Y,Xie L,Tian E,Li X,Wen Z,Li L,Chen L,Zhong Y,Ge RS
Tue Jan 01 00:00:00 EST 2019
Oncostatin M inhibits differentiation of rat stem Leydig cells in vivo and in vitro.
Journal of cellular and molecular medicine
Wang Y,Xie L,Tian E,Li X,Wen Z,Li L,Chen L,Zhong Y,Ge RS
Tue Jan 01 00:00:00 EST 2019
Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells.
Scientific reports
Pettinato G,Lehoux S,Ramanathan R,Salem MM,He LX,Muse O,Flaumenhaft R,Thompson MT,Rouse EA,Cummings RD,Wen X,Fisher RA
Thu Jun 20 00:00:00 EDT 2019
A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells.
Scientific reports
Ohta S,Ikemoto T,Wada Y,Saito Y,Yamada S,Imura S,Morine Y,Shimada M
Tue Dec 10 00:00:00 EST 2019
Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation.
iScience
Wang Y,Tatham MH,Schmidt-Heck W,Swann C,Singh-Dolt K,Meseguer-Ripolles J,Lucendo-Villarin B,Kunath T,Rudd TR,Smith AJH,Hengstler JG,Godoy P,Hay RT,Hay DC
300-10 was used in Cell Culture to demonstrate that nuclear HNF4α is essential for hepatic progenitor specification, and the introduction of point mutations in HNF4α's Small Ubiquitin-like Modifier consensus motif leads to disrupted hepatocyte differentiation.
Fri Jun 28 00:00:00 EDT 2019
SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation.
Nature communications
Kuroda T,Yasuda S,Tachi S,Matsuyama S,Kusakawa S,Tano K,Miura T,Matsuyama A,Sato Y
Wed May 15 00:00:00 EDT 2019
Generation of Functional Hepatocytes from Human Adipose-Derived MYC+ KLF4+ GMNN+ Stem Cells Analyzed by Single-Cell RNA-Seq Profiling.
Stem cells translational medicine
Li H,Zhu L,Chen H,Li T,Han Q,Wang S,Yao X,Feng H,Fan L,Gao S,Boyd R,Cao X,Zhu P,Li J,Keating A,Su X,Zhao RC
Thu Nov 01 00:00:00 EDT 2018
Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.
Journal of leukocyte biology
Kirchmeyer M,Servais FA,Hamdorf M,Nazarov PV,Ginolhac A,Halder R,Vallar L,Glanemann M,Rubie C,Lammert F,Kreis S,Behrmann I
Thu Nov 01 00:00:00 EDT 2018
TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis.
Nature communications
Zhang HX,Xu ZS,Lin H,Li M,Xia T,Cui K,Wang SY,Li Y,Shu HB,Wang YY
Fri Aug 24 00:00:00 EDT 2018
Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes.
Scientific reports
Schöbel A,Rösch K,Herker E
Thu Mar 01 00:00:00 EST 2018
Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications.
Stem cell reports
Ong J,Serra MP,Segal J,Cujba AM,Ng SS,Butler R,Millar V,Hatch S,Zimri S,Koike H,Chan K,Bonham A,Walk M,Voss T,Heaton N,Mitry R,Dhawan A,Ebner D,Danovi D,Nakauchi H,Rashid ST
Tue Mar 13 00:00:00 EDT 2018
JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.
The Journal of clinical investigation
Wang S,Liang K,Hu Q,Li P,Song J,Yang Y,Yao J,Mangala LS,Li C,Yang W,Park PK,Hawke DH,Zhou J,Zhou Y,Xia W,Hung MC,Marks JR,Gallick GE,Lopez-Berestein G,Flores ER,Sood AK,Huang S,Yu D,Yang L,Lin C
Fri Dec 01 00:00:00 EST 2017
JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.
The Journal of clinical investigation
Wang S,Liang K,Hu Q,Li P,Song J,Yang Y,Yao J,Mangala LS,Li C,Yang W,Park PK,Hawke DH,Zhou J,Zhou Y,Xia W,Hung MC,Marks JR,Gallick GE,Lopez-Berestein G,Flores ER,Sood AK,Huang S,Yu D,Yang L,Lin C
Fri Dec 01 00:00:00 EST 2017
A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.
The Journal of experimental medicine
Schwerd T,Twigg SRF,Aschenbrenner D,Manrique S,Miller KA,Taylor IB,Capitani M,McGowan SJ,Sweeney E,Weber A,Chen L,Bowness P,Riordan A,Cant A,Freeman AF,Milner JD,Holland SM,Frede N,Müller M,Schmidt-Arras D,Grimbacher B,Wall SA,Jones EY,Wilkie AOM,Uhlig HH
Mon Sep 04 00:00:00 EDT 2017
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.
Oncogene
Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW
Thu Jul 13 00:00:00 EDT 2017
Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production.
Cell death & disease
Zhang M,Wang J,Deng C,Jiang MH,Feng X,Xia K,Li W,Lai X,Xiao H,Ge RS,Gao Y,Xiang AP
Thu Oct 12 00:00:00 EDT 2017
Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis.
Scientific reports
Ayaub EA,Dubey A,Imani J,Botelho F,Kolb MRJ,Richards CD,Ask K
Mon Oct 16 00:00:00 EDT 2017
GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.
Scientific reports
Zeitvogel J,Jokmin N,Rieker S,Klug I,Brandenberger C,Werfel T
Tue Sep 19 00:00:00 EDT 2017
IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis.
Scientific reports
Travers J,Rochman M,Caldwell JM,Besse JA,Miracle CE,Rothenberg ME
Thu Dec 14 00:00:00 EST 2017
Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells.
Scientific reports
Kotaka M,Toyoda T,Yasuda K,Kitano Y,Okada C,Ohta A,Watanabe A,Uesugi M,Osafune K
Fri Dec 01 00:00:00 EST 2017
Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells.
Scientific reports
Kotaka M,Toyoda T,Yasuda K,Kitano Y,Okada C,Ohta A,Watanabe A,Uesugi M,Osafune K
Fri Dec 01 00:00:00 EST 2017
Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells.
Scientific reports
Kim HM,Kim JW,Choi Y,Chun HS,Im I,Han YM,Song CW,Yoon S,Park HJ
Mon Feb 22 00:00:00 EST 2016
STAT3-driven transcription depends upon the dimethylation of K49 by EZH2.
Proceedings of the National Academy of Sciences of the United States of America
Dasgupta M,Dermawan JK,Willard B,Stark GR
Tue Mar 31 00:00:00 EDT 2015
Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance.
Advanced healthcare materials
Villarin BL,Cameron K,Szkolnicka D,Rashidi H,Bates N,Kimber SJ,Flint O,Forbes SJ,Iredale JP,Bradley M,Hay DC
Wed Aug 26 00:00:00 EDT 2015
Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells.
Stem cell reports
Siller R,Greenhough S,Naumovska E,Sullivan GJ
Tue May 12 00:00:00 EDT 2015
Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes.
The Journal of biological chemistry
Im I,Jang MJ,Park SJ,Lee SH,Choi JH,Yoo HW,Kim S,Han YM
Fri Dec 04 00:00:00 EST 2015
CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells.
Stem cell reports
Kido T,Koui Y,Suzuki K,Kobayashi A,Miura Y,Chern EY,Tanaka M,Miyajima A
Tue Oct 13 00:00:00 EDT 2015
Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes.
Stem cell reports
Cameron K,Tan R,Schmidt-Heck W,Campos G,Lyall MJ,Wang Y,Lucendo-Villarin B,Szkolnicka D,Bates N,Kimber SJ,Hengstler JG,Godoy P,Forbes SJ,Hay DC
Tue Dec 08 00:00:00 EST 2015
Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.
Cell research
Jiang MH,Cai B,Tuo Y,Wang J,Zang ZJ,Tu X,Gao Y,Su Z,Li W,Li G,Zhang M,Jiao J,Wan Z,Deng C,Lahn BT,Xiang AP
Mon Dec 01 00:00:00 EST 2014
Leukemia propagating cells rebuild an evolving niche in response to therapy.
Cancer cell
Duan CW,Shi J,Chen J,Wang B,Yu YH,Qin X,Zhou XC,Cai YJ,Li ZQ,Zhang F,Yin MZ,Tao Y,Mi JQ,Li LH,Enver T,Chen GQ,Hong DL
Mon Jun 16 00:00:00 EDT 2014
Enabling autologous human liver regeneration with differentiated adipocyte stem cells.
Cell transplantation
Xu D,Nishimura T,Zheng M,Wu M,Su H,Sato N,Lee G,Michie S,Glenn J,Peltz G
300-10 was used in Cell Culture to determine a new method of hepatocyte-like cells development from adipocyte-like stem cells.
Tue Sep 15 00:00:00 EDT 2015
Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and β-catenin signaling.
The Journal of biological chemistry
Xu H,Tsang KS,Wang Y,Chan JC,Xu G,Gao WQ
Fri Sep 19 00:00:00 EDT 2014
Deriving functional hepatocytes from pluripotent stem cells.
Current protocols in stem cell biology
Szkolnicka D,Farnworth SL,Lucendo-Villarin B,Hay DC
300-10 was used in Cell Culture to develop robust hepatocyte differentiation methodologies for use with pluripotent stem cells.
Fri Aug 01 00:00:00 EDT 2014
Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
Stem cells (Dayton, Ohio)
Przybyla LM,Theunissen TW,Jaenisch R,Voldman J
Sat Jun 01 00:00:00 EDT 2013
Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.
Journal of immunology (Baltimore, Md. : 1950)
Van Rompaey L,Galien R,van der Aar EM,Clement-Lacroix P,Nelles L,Smets B,Lepescheux L,Christophe T,Conrath K,Vandeghinste N,Vayssiere B,De Vos S,Fletcher S,Brys R,van 't Klooster G,Feyen JH,Menet C
Tue Oct 01 00:00:00 EDT 2013
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Kajiwara M,Aoi T,Okita K,Takahashi R,Inoue H,Takayama N,Endo H,Eto K,Toguchida J,Uemoto S,Yamanaka S
Tue Jul 31 00:00:00 EDT 2012
Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor.
PloS one
Drechsler J,Grötzinger J,Hermanns HM
Thu Apr 25 00:00:00 EDT 2013
Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor.
PloS one
Drechsler J,Grötzinger J,Hermanns HM
Thu Apr 25 00:00:00 EDT 2013
Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor.
PloS one
Drechsler J,Grötzinger J,Hermanns HM
Thu Apr 25 00:00:00 EDT 2013
Ontological differences in first compared to third trimester human fetal placental chorionic stem cells.
PloS one
Jones GN,Moschidou D,Puga-Iglesias TI,Kuleszewicz K,Vanleene M,Shefelbine SJ,Bou-Gharios G,Fisk NM,David AL,De Coppi P,Guillot PV
Tue Jan 22 00:00:00 EST 2013
Core promoter recognition complex changes accompany liver development.
Proceedings of the National Academy of Sciences of the United States of America
D'Alessio JA,Ng R,Willenbring H,Tjian R
Tue Mar 08 00:00:00 EST 2011
Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.
Stem cell reviews and reports
Funakoshi N,Duret C,Pascussi JM,Blanc P,Maurel P,Daujat-Chavanieu M,Gerbal-Chaloin S
Thu Sep 01 00:00:00 EDT 2011
Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver.
PloS one
Baertschiger RM,Serre-Beinier V,Morel P,Bosco D,Peyrou M,Clément S,Sgroi A,Kaelin A,Buhler LH,Gonelle-Gispert C
Mon Aug 17 00:00:00 EDT 2009
Cell confluence-induced activation of signal transducer and activator of transcription-3 (Stat3) triggers epithelial dome formation via augmentation of sodium hydrogen exchanger-3 (NHE3) expression.
The Journal of biological chemistry
Su HW,Yeh HH,Wang SW,Shen MR,Chen TL,Kiela PR,Ghishan FK,Tang MJ
Fri Mar 30 00:00:00 EDT 2007
Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins.
The Journal of biological chemistry
Metz S,Wiesinger M,Vogt M,Lauks H,Schmalzing G,Heinrich PC,Müller-Newen G
Fri Jan 12 00:00:00 EST 2007
Are STATS arginine-methylated?
The Journal of biological chemistry
Komyod W,Bauer UM,Heinrich PC,Haan S,Behrmann I
Fri Jun 10 00:00:00 EDT 2005
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 EST 2003
A somatic cell genetic system for dissecting hemopoietic cytokine signal transduction.
The Journal of biological chemistry
Richardson RT,Starr R,Angus LJ,Hilton DJ
Fri Jul 12 00:00:00 EDT 2002
Identification of a gp130 cytokine receptor critical site involved in oncostatin M response.
The Journal of biological chemistry
Olivier C,Auguste P,Chabbert M,Lelièvre E,Chevalier S,Gascan H
Fri Feb 25 00:00:00 EST 2000