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Product Details
PEP-0818
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 17 amino acids near the amino terminus of human PCDH12.
PEP-0818 can be used as a blocking peptide with polyclonal antibody PA5-20703.
Target Information
Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2, 289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protocadherin-12; Vascular cadherin-2; vascular endothelial cadherin 2; Vascular endothelial cadherin-2; VE-cad-2; VE-cadherin 2
Gene Aliases: PCDH12; UNQ395/PRO731; VE-cadherin-2; VECAD2
UniProt ID: (Human) Q9NPG4
Entrez Gene ID: (Human) 51294
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